The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases

Current concepts of cellular oxygen-sensing include an isoform of the neutrophil NADPH oxidase, different electron carrier units of the mitochondrial electron transport chain (ETC), heme oxygenase-2 (HO-2), and a subfamily of 2-oxoglutarate dependent dioxygenases termed HIF (hypoxia inducible factor...

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Veröffentlicht in:	Cardiovascular research 2006-07, Vol.71 (2), p.195-207
Hauptverfasser:	Acker, Till, Fandrey, Joachim, Acker, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Hypoxia - physiology Cell Membrane - metabolism Cytochromes - metabolism Heme Oxygenase (Decyclizing) - metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Oxygen - metabolism Potassium Channels - metabolism Procollagen-Proline Dioxygenase - metabolism Reactive Oxygen Species - metabolism Signal Transduction - physiology
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