Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats

Posttraumatic stress disorder (PTSD) is associated with low levels of circulating cortisol, and recent studies suggest that cortisol administration may reduce PTSD symptoms. This study investigated the role of cortisol in the manifestation of anxiety- and fear-like symptoms in an animal model of PTS...

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Veröffentlicht in:	Biological psychiatry (1969) 2006-06, Vol.59 (12), p.1208-1218
Hauptverfasser:	Cohen, Hagit, Zohar, Joseph, Gidron, Yori, Matar, Michael A., Belkind, Dana, Loewenthal, Uri, Kozlovsky, Nitsan, Kaplan, Zeev
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Analysis of Variance Animal model Animals anxiety Anxiety disorders. Neuroses Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences corticosterone Disease Models, Animal Disease Susceptibility - blood Disease Susceptibility - psychology Fundamental and applied biological sciences. Psychology Hormones and behavior HPA axis Hydrocortisone - blood Hypothalamo-Hypophyseal System immune system maladapted Male Maze Learning - physiology Medical sciences Pituitary-Adrenal System Post-traumatic stress disorder posttraumatic stress disorder pro-inflammatory cytokines Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Rats Rats, Inbred F344 Rats, Inbred Lew Rats, Sprague-Dawley Reflex, Startle - physiology Stress Disorders, Post-Traumatic - blood Stress Disorders, Post-Traumatic - psychology Stress, Psychological - blood Stress, Psychological - psychology Time Factors well-adapted
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