Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats
Posttraumatic stress disorder (PTSD) is associated with low levels of circulating cortisol, and recent studies suggest that cortisol administration may reduce PTSD symptoms. This study investigated the role of cortisol in the manifestation of anxiety- and fear-like symptoms in an animal model of PTS...
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| Veröffentlicht in: | Biological psychiatry (1969) 2006-06, Vol.59 (12), p.1208-1218 |
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| container_title | Biological psychiatry (1969) |
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| creator | Cohen, Hagit Zohar, Joseph Gidron, Yori Matar, Michael A. Belkind, Dana Loewenthal, Uri Kozlovsky, Nitsan Kaplan, Zeev |
| description | Posttraumatic stress disorder (PTSD) is associated with low levels of circulating cortisol, and recent studies suggest that cortisol administration may reduce PTSD symptoms. This study investigated the role of cortisol in the manifestation of anxiety- and fear-like symptoms in an animal model of PTSD.
Magnitude of changes in prevalence of anxiety-like behaviors on the elevated plus-maze and nonhabituated exaggerated startle reaction were compared in three strains of rats exposed to predator stress, with and without prior corticosterone treatment. Extreme behavioral changes in both paradigms implied an extreme behavioral response (EBR), representing PTSD-like symptoms.
Lewis rats exhibited greater baseline anxiety-like behaviors and greater stress-induced increases in anxiety-like behaviors than Fischer F344 or Sprague–Dawley rats, with only minor corticosterone increases following stress. Prevalence of EBR was 50% among Lewis rats compared with 10% of Fischer F344 and 25% of Sprague–Dawley rats. Administering corticosterone 1 hour before stress exposure reduced the prevalence of EBR from 50% to 8% in the Lewis rats.
These results suggest that a blunted HPA response to stress may play a causal role in this model of PTSD and that this susceptibility may be prevented by administration of cortisol before stress exposure. |
| doi_str_mv | 10.1016/j.biopsych.2005.12.003 |
| format | Article |
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Magnitude of changes in prevalence of anxiety-like behaviors on the elevated plus-maze and nonhabituated exaggerated startle reaction were compared in three strains of rats exposed to predator stress, with and without prior corticosterone treatment. Extreme behavioral changes in both paradigms implied an extreme behavioral response (EBR), representing PTSD-like symptoms.
Lewis rats exhibited greater baseline anxiety-like behaviors and greater stress-induced increases in anxiety-like behaviors than Fischer F344 or Sprague–Dawley rats, with only minor corticosterone increases following stress. Prevalence of EBR was 50% among Lewis rats compared with 10% of Fischer F344 and 25% of Sprague–Dawley rats. Administering corticosterone 1 hour before stress exposure reduced the prevalence of EBR from 50% to 8% in the Lewis rats.
These results suggest that a blunted HPA response to stress may play a causal role in this model of PTSD and that this susceptibility may be prevented by administration of cortisol before stress exposure.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2005.12.003</identifier><identifier>PMID: 16458266</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult and adolescent clinical studies ; Analysis of Variance ; Animal model ; Animals ; anxiety ; Anxiety disorders. Neuroses ; Behavior, Animal - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; corticosterone ; Disease Models, Animal ; Disease Susceptibility - blood ; Disease Susceptibility - psychology ; Fundamental and applied biological sciences. Psychology ; Hormones and behavior ; HPA axis ; Hydrocortisone - blood ; Hypothalamo-Hypophyseal System ; immune system ; maladapted ; Male ; Maze Learning - physiology ; Medical sciences ; Pituitary-Adrenal System ; Post-traumatic stress disorder ; posttraumatic stress disorder ; pro-inflammatory cytokines ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Rats ; Rats, Inbred F344 ; Rats, Inbred Lew ; Rats, Sprague-Dawley ; Reflex, Startle - physiology ; Stress Disorders, Post-Traumatic - blood ; Stress Disorders, Post-Traumatic - psychology ; Stress, Psychological - blood ; Stress, Psychological - psychology ; Time Factors ; well-adapted</subject><ispartof>Biological psychiatry (1969), 2006-06, Vol.59 (12), p.1208-1218</ispartof><rights>2006 Society of Biological Psychiatry</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c524t-c9ca529a88d87b39950fe90391e2f0f2f70a5c0b6eb7e7f49ecc1a70877ffcca3</citedby><cites>FETCH-LOGICAL-c524t-c9ca529a88d87b39950fe90391e2f0f2f70a5c0b6eb7e7f49ecc1a70877ffcca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopsych.2005.12.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17930576$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16458266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, Hagit</creatorcontrib><creatorcontrib>Zohar, Joseph</creatorcontrib><creatorcontrib>Gidron, Yori</creatorcontrib><creatorcontrib>Matar, Michael A.</creatorcontrib><creatorcontrib>Belkind, Dana</creatorcontrib><creatorcontrib>Loewenthal, Uri</creatorcontrib><creatorcontrib>Kozlovsky, Nitsan</creatorcontrib><creatorcontrib>Kaplan, Zeev</creatorcontrib><title>Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Posttraumatic stress disorder (PTSD) is associated with low levels of circulating cortisol, and recent studies suggest that cortisol administration may reduce PTSD symptoms. This study investigated the role of cortisol in the manifestation of anxiety- and fear-like symptoms in an animal model of PTSD.
Magnitude of changes in prevalence of anxiety-like behaviors on the elevated plus-maze and nonhabituated exaggerated startle reaction were compared in three strains of rats exposed to predator stress, with and without prior corticosterone treatment. Extreme behavioral changes in both paradigms implied an extreme behavioral response (EBR), representing PTSD-like symptoms.
Lewis rats exhibited greater baseline anxiety-like behaviors and greater stress-induced increases in anxiety-like behaviors than Fischer F344 or Sprague–Dawley rats, with only minor corticosterone increases following stress. Prevalence of EBR was 50% among Lewis rats compared with 10% of Fischer F344 and 25% of Sprague–Dawley rats. Administering corticosterone 1 hour before stress exposure reduced the prevalence of EBR from 50% to 8% in the Lewis rats.
These results suggest that a blunted HPA response to stress may play a causal role in this model of PTSD and that this susceptibility may be prevented by administration of cortisol before stress exposure.</description><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Animal model</subject><subject>Animals</subject><subject>anxiety</subject><subject>Anxiety disorders. Neuroses</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>corticosterone</subject><subject>Disease Models, Animal</subject><subject>Disease Susceptibility - blood</subject><subject>Disease Susceptibility - psychology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and behavior</subject><subject>HPA axis</subject><subject>Hydrocortisone - blood</subject><subject>Hypothalamo-Hypophyseal System</subject><subject>immune system</subject><subject>maladapted</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Medical sciences</subject><subject>Pituitary-Adrenal System</subject><subject>Post-traumatic stress disorder</subject><subject>posttraumatic stress disorder</subject><subject>pro-inflammatory cytokines</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Lew</subject><subject>Rats, Sprague-Dawley</subject><subject>Reflex, Startle - physiology</subject><subject>Stress Disorders, Post-Traumatic - blood</subject><subject>Stress Disorders, Post-Traumatic - psychology</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - psychology</subject><subject>Time Factors</subject><subject>well-adapted</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpSbZp_kLwpb3ZHckry7p1G_IFgYakPQtZHlEtXtvVyKX772Ozm-aYkxh43tHwPoxdcCg48OrrtmjCMNLe_S4EgCy4KADKd2zFa1XmYg3iPVsBQJWXQpSn7CPRdh6VEPyEnfJqLWtRVSvmv3dTn7DNbh822eZfoOwRaRx6wiwN2VOKSJTd9b6bsHdI2dNEDscUmtCFtF-Yh4FSinba2RTcS-L_ktBnjzbRJ_bB247w_PiesV_XVz8vb_P7Hzd3l5v73EmxTrnTzkqhbV23tWpKrSV41FBqjsKDF16BlQ6aChuFyq81Osetglop752z5Rn7ctg7xuHPhJTMLswHd53tcZjIVLVUXMn6TZBrBeXc0QxWB9DFgSiiN2MMOxv3hoNZVJiteVFhFhWGCzOrmIMXxx-mZofta-zY_Qx8PgKWnO18tL0L9MopXYJUC_ftwOFc3N-A0ZALi402RHTJtEN465ZnIp6scA</recordid><startdate>20060615</startdate><enddate>20060615</enddate><creator>Cohen, Hagit</creator><creator>Zohar, Joseph</creator><creator>Gidron, Yori</creator><creator>Matar, Michael A.</creator><creator>Belkind, Dana</creator><creator>Loewenthal, Uri</creator><creator>Kozlovsky, Nitsan</creator><creator>Kaplan, Zeev</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20060615</creationdate><title>Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats</title><author>Cohen, Hagit ; Zohar, Joseph ; Gidron, Yori ; Matar, Michael A. ; Belkind, Dana ; Loewenthal, Uri ; Kozlovsky, Nitsan ; Kaplan, Zeev</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-c9ca529a88d87b39950fe90391e2f0f2f70a5c0b6eb7e7f49ecc1a70877ffcca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Animal model</topic><topic>Animals</topic><topic>anxiety</topic><topic>Anxiety disorders. Neuroses</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>corticosterone</topic><topic>Disease Models, Animal</topic><topic>Disease Susceptibility - blood</topic><topic>Disease Susceptibility - psychology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and behavior</topic><topic>HPA axis</topic><topic>Hydrocortisone - blood</topic><topic>Hypothalamo-Hypophyseal System</topic><topic>immune system</topic><topic>maladapted</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Medical sciences</topic><topic>Pituitary-Adrenal System</topic><topic>Post-traumatic stress disorder</topic><topic>posttraumatic stress disorder</topic><topic>pro-inflammatory cytokines</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Inbred Lew</topic><topic>Rats, Sprague-Dawley</topic><topic>Reflex, Startle - physiology</topic><topic>Stress Disorders, Post-Traumatic - blood</topic><topic>Stress Disorders, Post-Traumatic - psychology</topic><topic>Stress, Psychological - blood</topic><topic>Stress, Psychological - psychology</topic><topic>Time Factors</topic><topic>well-adapted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, Hagit</creatorcontrib><creatorcontrib>Zohar, Joseph</creatorcontrib><creatorcontrib>Gidron, Yori</creatorcontrib><creatorcontrib>Matar, Michael A.</creatorcontrib><creatorcontrib>Belkind, Dana</creatorcontrib><creatorcontrib>Loewenthal, Uri</creatorcontrib><creatorcontrib>Kozlovsky, Nitsan</creatorcontrib><creatorcontrib>Kaplan, Zeev</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, Hagit</au><au>Zohar, Joseph</au><au>Gidron, Yori</au><au>Matar, Michael A.</au><au>Belkind, Dana</au><au>Loewenthal, Uri</au><au>Kozlovsky, Nitsan</au><au>Kaplan, Zeev</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2006-06-15</date><risdate>2006</risdate><volume>59</volume><issue>12</issue><spage>1208</spage><epage>1218</epage><pages>1208-1218</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Posttraumatic stress disorder (PTSD) is associated with low levels of circulating cortisol, and recent studies suggest that cortisol administration may reduce PTSD symptoms. This study investigated the role of cortisol in the manifestation of anxiety- and fear-like symptoms in an animal model of PTSD.
Magnitude of changes in prevalence of anxiety-like behaviors on the elevated plus-maze and nonhabituated exaggerated startle reaction were compared in three strains of rats exposed to predator stress, with and without prior corticosterone treatment. Extreme behavioral changes in both paradigms implied an extreme behavioral response (EBR), representing PTSD-like symptoms.
Lewis rats exhibited greater baseline anxiety-like behaviors and greater stress-induced increases in anxiety-like behaviors than Fischer F344 or Sprague–Dawley rats, with only minor corticosterone increases following stress. Prevalence of EBR was 50% among Lewis rats compared with 10% of Fischer F344 and 25% of Sprague–Dawley rats. Administering corticosterone 1 hour before stress exposure reduced the prevalence of EBR from 50% to 8% in the Lewis rats.
These results suggest that a blunted HPA response to stress may play a causal role in this model of PTSD and that this susceptibility may be prevented by administration of cortisol before stress exposure.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16458266</pmid><doi>10.1016/j.biopsych.2005.12.003</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Analysis of Variance Animal model Animals anxiety Anxiety disorders. Neuroses Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences corticosterone Disease Models, Animal Disease Susceptibility - blood Disease Susceptibility - psychology Fundamental and applied biological sciences. Psychology Hormones and behavior HPA axis Hydrocortisone - blood Hypothalamo-Hypophyseal System immune system maladapted Male Maze Learning - physiology Medical sciences Pituitary-Adrenal System Post-traumatic stress disorder posttraumatic stress disorder pro-inflammatory cytokines Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Rats Rats, Inbred F344 Rats, Inbred Lew Rats, Sprague-Dawley Reflex, Startle - physiology Stress Disorders, Post-Traumatic - blood Stress Disorders, Post-Traumatic - psychology Stress, Psychological - blood Stress, Psychological - psychology Time Factors well-adapted |
| title | Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats |
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