Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats

Posttraumatic stress disorder (PTSD) is associated with low levels of circulating cortisol, and recent studies suggest that cortisol administration may reduce PTSD symptoms. This study investigated the role of cortisol in the manifestation of anxiety- and fear-like symptoms in an animal model of PTS...

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Veröffentlicht in:Biological psychiatry (1969) 2006-06, Vol.59 (12), p.1208-1218
Hauptverfasser: Cohen, Hagit, Zohar, Joseph, Gidron, Yori, Matar, Michael A., Belkind, Dana, Loewenthal, Uri, Kozlovsky, Nitsan, Kaplan, Zeev
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container_end_page 1218
container_issue 12
container_start_page 1208
container_title Biological psychiatry (1969)
container_volume 59
creator Cohen, Hagit
Zohar, Joseph
Gidron, Yori
Matar, Michael A.
Belkind, Dana
Loewenthal, Uri
Kozlovsky, Nitsan
Kaplan, Zeev
description Posttraumatic stress disorder (PTSD) is associated with low levels of circulating cortisol, and recent studies suggest that cortisol administration may reduce PTSD symptoms. This study investigated the role of cortisol in the manifestation of anxiety- and fear-like symptoms in an animal model of PTSD. Magnitude of changes in prevalence of anxiety-like behaviors on the elevated plus-maze and nonhabituated exaggerated startle reaction were compared in three strains of rats exposed to predator stress, with and without prior corticosterone treatment. Extreme behavioral changes in both paradigms implied an extreme behavioral response (EBR), representing PTSD-like symptoms. Lewis rats exhibited greater baseline anxiety-like behaviors and greater stress-induced increases in anxiety-like behaviors than Fischer F344 or Sprague–Dawley rats, with only minor corticosterone increases following stress. Prevalence of EBR was 50% among Lewis rats compared with 10% of Fischer F344 and 25% of Sprague–Dawley rats. Administering corticosterone 1 hour before stress exposure reduced the prevalence of EBR from 50% to 8% in the Lewis rats. These results suggest that a blunted HPA response to stress may play a causal role in this model of PTSD and that this susceptibility may be prevented by administration of cortisol before stress exposure.
doi_str_mv 10.1016/j.biopsych.2005.12.003
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Psychiatry</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Lew</subject><subject>Rats, Sprague-Dawley</subject><subject>Reflex, Startle - physiology</subject><subject>Stress Disorders, Post-Traumatic - blood</subject><subject>Stress Disorders, Post-Traumatic - psychology</subject><subject>Stress, Psychological - blood</subject><subject>Stress, Psychological - psychology</subject><subject>Time Factors</subject><subject>well-adapted</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpSbZp_kLwpb3ZHckry7p1G_IFgYakPQtZHlEtXtvVyKX772Ozm-aYkxh43tHwPoxdcCg48OrrtmjCMNLe_S4EgCy4KADKd2zFa1XmYg3iPVsBQJWXQpSn7CPRdh6VEPyEnfJqLWtRVSvmv3dTn7DNbh822eZfoOwRaRx6wiwN2VOKSJTd9b6bsHdI2dNEDscUmtCFtF-Yh4FSinba2RTcS-L_ktBnjzbRJ_bB247w_PiesV_XVz8vb_P7Hzd3l5v73EmxTrnTzkqhbV23tWpKrSV41FBqjsKDF16BlQ6aChuFyq81Osetglop752z5Rn7ctg7xuHPhJTMLswHd53tcZjIVLVUXMn6TZBrBeXc0QxWB9DFgSiiN2MMOxv3hoNZVJiteVFhFhWGCzOrmIMXxx-mZofta-zY_Qx8PgKWnO18tL0L9MopXYJUC_ftwOFc3N-A0ZALi402RHTJtEN465ZnIp6scA</recordid><startdate>20060615</startdate><enddate>20060615</enddate><creator>Cohen, Hagit</creator><creator>Zohar, Joseph</creator><creator>Gidron, Yori</creator><creator>Matar, Michael A.</creator><creator>Belkind, Dana</creator><creator>Loewenthal, Uri</creator><creator>Kozlovsky, Nitsan</creator><creator>Kaplan, Zeev</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20060615</creationdate><title>Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats</title><author>Cohen, Hagit ; Zohar, Joseph ; Gidron, Yori ; Matar, Michael A. ; Belkind, Dana ; Loewenthal, Uri ; Kozlovsky, Nitsan ; Kaplan, Zeev</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c524t-c9ca529a88d87b39950fe90391e2f0f2f70a5c0b6eb7e7f49ecc1a70877ffcca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Animal model</topic><topic>Animals</topic><topic>anxiety</topic><topic>Anxiety disorders. 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subjects Adult and adolescent clinical studies
Analysis of Variance
Animal model
Animals
anxiety
Anxiety disorders. Neuroses
Behavior, Animal - physiology
Behavioral psychophysiology
Biological and medical sciences
corticosterone
Disease Models, Animal
Disease Susceptibility - blood
Disease Susceptibility - psychology
Fundamental and applied biological sciences. Psychology
Hormones and behavior
HPA axis
Hydrocortisone - blood
Hypothalamo-Hypophyseal System
immune system
maladapted
Male
Maze Learning - physiology
Medical sciences
Pituitary-Adrenal System
Post-traumatic stress disorder
posttraumatic stress disorder
pro-inflammatory cytokines
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Rats
Rats, Inbred F344
Rats, Inbred Lew
Rats, Sprague-Dawley
Reflex, Startle - physiology
Stress Disorders, Post-Traumatic - blood
Stress Disorders, Post-Traumatic - psychology
Stress, Psychological - blood
Stress, Psychological - psychology
Time Factors
well-adapted
title Blunted HPA Axis Response to Stress Influences Susceptibility to Posttraumatic Stress Response in Rats
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