Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer
Chronic H. pylori infection is the main cause of ulcer disease which depicts a major burden of our healthy care systems. The individual host immune response plays a pivotal role in the outcome of the infection but genetic susceptibility to develop gastric ulcer is unknown. IL-1β and its natural rece...
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| Veröffentlicht in: | Immunology Letters 2005-09, Vol.100 (2), p.107-112 |
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| creator | Hellmig, Stephan Titz, Andrea Steinel, Stefanie Ott, Stephan Fölsch, Ulrich Robert Hampe, Jochen Schreiber, Stefan |
| description | Chronic
H. pylori infection is the main cause of ulcer disease which depicts a major burden of our healthy care systems. The individual host immune response plays a pivotal role in the outcome of the infection but genetic susceptibility to develop gastric ulcer is unknown. IL-1β and its natural receptor antagonist IL-1ra are involved in the inflammatory response to
H. pylori infection. Thus, we investigated the influence of functional genetic variants in the IL-1 gene cluster on the development of gastric ulcer disease.
390
H. pylori infected patients were genotyped for IL-1B −31 and +3954 by TaqMan technology. Alleles of IL-1RN 86VNTR were determined by gel electrophoresis after amplification. Three hundred and sixty healthy blood donors were included as healthy controls.
Carriage of the IL-1B −31 C allele conferred a increased but not significant risk for
H. pylori infection (OR: 1.3, Wald 95% CI: 0.8
<
OR
<
2.1). Patients carrying short allele 2 of IL-1RN had a 1.6-fold significantly increased risk for the development of gastric ulcer (Pearson's
=
4.0,
p
=
0.044, OR: 1.6, Wald 95% CI: 1.0
<
OR
<
2.4).
Our results underline the crucial role of the host immune response to
H. pylori infection and confirm the importance of polymorphisms in the IL-1 cluster as a factor to give rise to different clinical outcomes. Further studies are needed to fully understand the pathophysiological effect of polymorphisms in the IL-1 cluster in
H. pylori associated ulcer disease and susceptibility to infection itself. |
| doi_str_mv | 10.1016/j.imlet.2005.04.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68571127</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S016524780500091X</els_id><sourcerecordid>68571127</sourcerecordid><originalsourceid>FETCH-LOGICAL-c388t-c17f3c6cffaa3b45e54f30a424fb632abf1ab6d809b204e250dd2865c8d621753</originalsourceid><addsrcrecordid>eNqFkU1r3DAURUVpaKZJf0GhaNWdXX3amkUXJaTNwEA3yVrI0lOiQbZcSQ7Mv6-nM9Bdu3qbc--DexD6SElLCe2-HNowRqgtI0S2RLSE0DdoQ1W_bYgU7C3arJRsmOjVNXpfymEFJBf8HbqmUimpiNgg2E0-LjBZwMnj3b6h-BkmwDYupULGc4rHMeX5JZSx4DTh-gLYwSvENI8w1VPqocXzMaYcsCkl2WAqOPxsSs3B4iVayLfoyptY4MPl3qCn7_ePdw_N_ueP3d23fWO5UrWxtPfcdtZ7Y_ggJEjhOTGCCT90nJnBUzN0TpHtwIgAJolzTHXSKtcx2kt-gz6fe-ecfi1Qqh5DsRCjmSAtRXdK9pSy_r8gI_22Ez1bQX4GbU6lZPB6zmE0-agp0ScN-qD_aNAnDZoIva68pj5d6pdhBPc3c9l9Bb6eAVjXeA2QdbHhZMGFDLZql8I_H_wGLy6ajg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20796472</pqid></control><display><type>article</type><title>Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer</title><source>Wiley Free Content</source><source>MEDLINE</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Hellmig, Stephan ; Titz, Andrea ; Steinel, Stefanie ; Ott, Stephan ; Fölsch, Ulrich Robert ; Hampe, Jochen ; Schreiber, Stefan</creator><creatorcontrib>Hellmig, Stephan ; Titz, Andrea ; Steinel, Stefanie ; Ott, Stephan ; Fölsch, Ulrich Robert ; Hampe, Jochen ; Schreiber, Stefan</creatorcontrib><description>Chronic
H. pylori infection is the main cause of ulcer disease which depicts a major burden of our healthy care systems. The individual host immune response plays a pivotal role in the outcome of the infection but genetic susceptibility to develop gastric ulcer is unknown. IL-1β and its natural receptor antagonist IL-1ra are involved in the inflammatory response to
H. pylori infection. Thus, we investigated the influence of functional genetic variants in the IL-1 gene cluster on the development of gastric ulcer disease.
390
H. pylori infected patients were genotyped for IL-1B −31 and +3954 by TaqMan technology. Alleles of IL-1RN 86VNTR were determined by gel electrophoresis after amplification. Three hundred and sixty healthy blood donors were included as healthy controls.
Carriage of the IL-1B −31 C allele conferred a increased but not significant risk for
H. pylori infection (OR: 1.3, Wald 95% CI: 0.8
<
OR
<
2.1). Patients carrying short allele 2 of IL-1RN had a 1.6-fold significantly increased risk for the development of gastric ulcer (Pearson's
=
4.0,
p
=
0.044, OR: 1.6, Wald 95% CI: 1.0
<
OR
<
2.4).
Our results underline the crucial role of the host immune response to
H. pylori infection and confirm the importance of polymorphisms in the IL-1 cluster as a factor to give rise to different clinical outcomes. Further studies are needed to fully understand the pathophysiological effect of polymorphisms in the IL-1 cluster in
H. pylori associated ulcer disease and susceptibility to infection itself.</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1016/j.imlet.2005.04.001</identifier><identifier>PMID: 15885804</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Female ; Gastric ulcer ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; H. pylori ; Helicobacter Infections - genetics ; Helicobacter Infections - immunology ; Helicobacter pylori ; Humans ; IL-1 gene cluster ; Interleukin-1 - genetics ; Male ; Middle Aged ; Multigene Family ; Polymorphism, Genetic ; Stomach Ulcer - genetics ; Stomach Ulcer - immunology</subject><ispartof>Immunology Letters, 2005-09, Vol.100 (2), p.107-112</ispartof><rights>2005 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-c17f3c6cffaa3b45e54f30a424fb632abf1ab6d809b204e250dd2865c8d621753</citedby><cites>FETCH-LOGICAL-c388t-c17f3c6cffaa3b45e54f30a424fb632abf1ab6d809b204e250dd2865c8d621753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016524780500091X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15885804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hellmig, Stephan</creatorcontrib><creatorcontrib>Titz, Andrea</creatorcontrib><creatorcontrib>Steinel, Stefanie</creatorcontrib><creatorcontrib>Ott, Stephan</creatorcontrib><creatorcontrib>Fölsch, Ulrich Robert</creatorcontrib><creatorcontrib>Hampe, Jochen</creatorcontrib><creatorcontrib>Schreiber, Stefan</creatorcontrib><title>Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer</title><title>Immunology Letters</title><addtitle>Immunol Lett</addtitle><description>Chronic
H. pylori infection is the main cause of ulcer disease which depicts a major burden of our healthy care systems. The individual host immune response plays a pivotal role in the outcome of the infection but genetic susceptibility to develop gastric ulcer is unknown. IL-1β and its natural receptor antagonist IL-1ra are involved in the inflammatory response to
H. pylori infection. Thus, we investigated the influence of functional genetic variants in the IL-1 gene cluster on the development of gastric ulcer disease.
390
H. pylori infected patients were genotyped for IL-1B −31 and +3954 by TaqMan technology. Alleles of IL-1RN 86VNTR were determined by gel electrophoresis after amplification. Three hundred and sixty healthy blood donors were included as healthy controls.
Carriage of the IL-1B −31 C allele conferred a increased but not significant risk for
H. pylori infection (OR: 1.3, Wald 95% CI: 0.8
<
OR
<
2.1). Patients carrying short allele 2 of IL-1RN had a 1.6-fold significantly increased risk for the development of gastric ulcer (Pearson's
=
4.0,
p
=
0.044, OR: 1.6, Wald 95% CI: 1.0
<
OR
<
2.4).
Our results underline the crucial role of the host immune response to
H. pylori infection and confirm the importance of polymorphisms in the IL-1 cluster as a factor to give rise to different clinical outcomes. Further studies are needed to fully understand the pathophysiological effect of polymorphisms in the IL-1 cluster in
H. pylori associated ulcer disease and susceptibility to infection itself.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Gastric ulcer</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>H. pylori</subject><subject>Helicobacter Infections - genetics</subject><subject>Helicobacter Infections - immunology</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>IL-1 gene cluster</subject><subject>Interleukin-1 - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multigene Family</subject><subject>Polymorphism, Genetic</subject><subject>Stomach Ulcer - genetics</subject><subject>Stomach Ulcer - immunology</subject><issn>0165-2478</issn><issn>1879-0542</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAURUVpaKZJf0GhaNWdXX3amkUXJaTNwEA3yVrI0lOiQbZcSQ7Mv6-nM9Bdu3qbc--DexD6SElLCe2-HNowRqgtI0S2RLSE0DdoQ1W_bYgU7C3arJRsmOjVNXpfymEFJBf8HbqmUimpiNgg2E0-LjBZwMnj3b6h-BkmwDYupULGc4rHMeX5JZSx4DTh-gLYwSvENI8w1VPqocXzMaYcsCkl2WAqOPxsSs3B4iVayLfoyptY4MPl3qCn7_ePdw_N_ueP3d23fWO5UrWxtPfcdtZ7Y_ggJEjhOTGCCT90nJnBUzN0TpHtwIgAJolzTHXSKtcx2kt-gz6fe-ecfi1Qqh5DsRCjmSAtRXdK9pSy_r8gI_22Ez1bQX4GbU6lZPB6zmE0-agp0ScN-qD_aNAnDZoIva68pj5d6pdhBPc3c9l9Bb6eAVjXeA2QdbHhZMGFDLZql8I_H_wGLy6ajg</recordid><startdate>20050915</startdate><enddate>20050915</enddate><creator>Hellmig, Stephan</creator><creator>Titz, Andrea</creator><creator>Steinel, Stefanie</creator><creator>Ott, Stephan</creator><creator>Fölsch, Ulrich Robert</creator><creator>Hampe, Jochen</creator><creator>Schreiber, Stefan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050915</creationdate><title>Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer</title><author>Hellmig, Stephan ; Titz, Andrea ; Steinel, Stefanie ; Ott, Stephan ; Fölsch, Ulrich Robert ; Hampe, Jochen ; Schreiber, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-c17f3c6cffaa3b45e54f30a424fb632abf1ab6d809b204e250dd2865c8d621753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Gastric ulcer</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>H. pylori</topic><topic>Helicobacter Infections - genetics</topic><topic>Helicobacter Infections - immunology</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>IL-1 gene cluster</topic><topic>Interleukin-1 - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multigene Family</topic><topic>Polymorphism, Genetic</topic><topic>Stomach Ulcer - genetics</topic><topic>Stomach Ulcer - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hellmig, Stephan</creatorcontrib><creatorcontrib>Titz, Andrea</creatorcontrib><creatorcontrib>Steinel, Stefanie</creatorcontrib><creatorcontrib>Ott, Stephan</creatorcontrib><creatorcontrib>Fölsch, Ulrich Robert</creatorcontrib><creatorcontrib>Hampe, Jochen</creatorcontrib><creatorcontrib>Schreiber, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology Letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hellmig, Stephan</au><au>Titz, Andrea</au><au>Steinel, Stefanie</au><au>Ott, Stephan</au><au>Fölsch, Ulrich Robert</au><au>Hampe, Jochen</au><au>Schreiber, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer</atitle><jtitle>Immunology Letters</jtitle><addtitle>Immunol Lett</addtitle><date>2005-09-15</date><risdate>2005</risdate><volume>100</volume><issue>2</issue><spage>107</spage><epage>112</epage><pages>107-112</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><eissn>1365-2567</eissn><abstract>Chronic
H. pylori infection is the main cause of ulcer disease which depicts a major burden of our healthy care systems. The individual host immune response plays a pivotal role in the outcome of the infection but genetic susceptibility to develop gastric ulcer is unknown. IL-1β and its natural receptor antagonist IL-1ra are involved in the inflammatory response to
H. pylori infection. Thus, we investigated the influence of functional genetic variants in the IL-1 gene cluster on the development of gastric ulcer disease.
390
H. pylori infected patients were genotyped for IL-1B −31 and +3954 by TaqMan technology. Alleles of IL-1RN 86VNTR were determined by gel electrophoresis after amplification. Three hundred and sixty healthy blood donors were included as healthy controls.
Carriage of the IL-1B −31 C allele conferred a increased but not significant risk for
H. pylori infection (OR: 1.3, Wald 95% CI: 0.8
<
OR
<
2.1). Patients carrying short allele 2 of IL-1RN had a 1.6-fold significantly increased risk for the development of gastric ulcer (Pearson's
=
4.0,
p
=
0.044, OR: 1.6, Wald 95% CI: 1.0
<
OR
<
2.4).
Our results underline the crucial role of the host immune response to
H. pylori infection and confirm the importance of polymorphisms in the IL-1 cluster as a factor to give rise to different clinical outcomes. Further studies are needed to fully understand the pathophysiological effect of polymorphisms in the IL-1 cluster in
H. pylori associated ulcer disease and susceptibility to infection itself.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>15885804</pmid><doi>10.1016/j.imlet.2005.04.001</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Immunology Letters, 2005-09, Vol.100 (2), p.107-112 |
| issn | 0165-2478 1879-0542 1365-2567 |
| language | eng |
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| source | Wiley Free Content; MEDLINE; IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Aged Aged, 80 and over Female Gastric ulcer Gene Frequency Genetic Predisposition to Disease Genotype H. pylori Helicobacter Infections - genetics Helicobacter Infections - immunology Helicobacter pylori Humans IL-1 gene cluster Interleukin-1 - genetics Male Middle Aged Multigene Family Polymorphism, Genetic Stomach Ulcer - genetics Stomach Ulcer - immunology |
| title | Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer |
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