Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse

The expression, responsiveness and regulation of mouse Toll-like receptors (TLRs) in bone marrow-derived macrophages (BM-Ø) were investigated prior to and following the development of diabetes. Expression of TLR3 and TLR5 was significantly higher in newly diabetic non-obese diabetic (NOD) mice when...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International immunology 2006-07, Vol.18 (7), p.1101-1113
Hauptverfasser:	Mohammad, Mohammad K., Morran, Michael, Slotterbeck, Brandon, Leaman, Douglas W., Sun, Yaping, Grafenstein, Hermann von, Hong, Soon-Cheol, McInerney, Marcia F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology autoimmunity Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Cells, Cultured cytokines Cytokines - immunology diabetes complications Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Lipopolysaccharides - pharmacology Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred BALB C Mice, Inbred NOD periodontitis Poly I-C - pharmacology rodent Species Specificity Toll-Like Receptor 3 - biosynthesis Toll-Like Receptor 3 - immunology Toll-Like Receptor 4 - biosynthesis Toll-Like Receptor 4 - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!