Effect of indomethacin on motor activity and spinal cord free fatty acid content after experimental spinal cord injury in rabbits
Study design: Determination of functional and biochemical parameters as well as the effect of specific therapies on these parameters, in the experimental model of neurotrauma in rabbits. Objective: To assess the effect of indomethacin (0.1–3.0 mg/kg for 9 days), a potent inhibitor of endogenous pros...
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| Veröffentlicht in: | Spinal cord 2005-09, Vol.43 (9), p.519-526 |
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| creator | PANTOVIC, R DRAGANIC, P ERAKOVIC, V BLAGOVIC, B MILIN, C SIMONIC, A |
| description | Study design:
Determination of functional and biochemical parameters as well as the effect of specific therapies on these parameters, in the experimental model of neurotrauma in rabbits.
Objective:
To assess the effect of indomethacin (0.1–3.0 mg/kg for 9 days), a potent inhibitor of endogenous prostaglandin synthesis, on the motor activity and on the spinal cord tissue concentration of free palmitic, stearic, oleic, arachidonic and docosahexaenoic acids in an experimental model of a spinal cord injury in rabbits.
Setting:
Faculty of Medicine, University of Rijeka, Croatia.
Methods:
The animals were randomly divided into nine experimental groups, four sham and/or vehicle-treated and five indomethacin-treated (including one sham-operated and four injured groups). Laminectomy was followed by contusion of the spinal cord, using a modification of the technique of Albin. Motor activity was controlled daily during the course of the next nine postoperation days and scored using Tarlov's system. Spinal cord samples from the impact injury site were taken and frozen in liquid nitrogen. Total lipids were isolated and purified by a modification of the method of Folch. Free fatty acids (FFAs) were separated from the total lipid extract by preparative thin-layer chromatography, converted to the corresponding methyl esters and identified using gas chromatography, using nonadecanoic acid as the internal standard.
Results:
The concentrations of all analysed free fatty acids were increased in the spinal cord after neurotrauma, in comparison to control tissues. Treatment of injured rabbits with indomethacin resulted in a significant decrease in spinal cord FFAs and exerted a positive effect on neurotrauma-induced motor impairment.
Conclusion:
These results indicate a mechanism whereby indomethacin protects rabbits from the sequellae of neuronal damage caused by trauma, and suggests that it may be beneficial in the therapy of neurotrauma.
Sponsorship:
This work was supported by the Croatian Ministry of Science and Technology (project 062019). |
| doi_str_mv | 10.1038/sj.sc.3101763 |
| format | Article |
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Determination of functional and biochemical parameters as well as the effect of specific therapies on these parameters, in the experimental model of neurotrauma in rabbits.
Objective:
To assess the effect of indomethacin (0.1–3.0 mg/kg for 9 days), a potent inhibitor of endogenous prostaglandin synthesis, on the motor activity and on the spinal cord tissue concentration of free palmitic, stearic, oleic, arachidonic and docosahexaenoic acids in an experimental model of a spinal cord injury in rabbits.
Setting:
Faculty of Medicine, University of Rijeka, Croatia.
Methods:
The animals were randomly divided into nine experimental groups, four sham and/or vehicle-treated and five indomethacin-treated (including one sham-operated and four injured groups). Laminectomy was followed by contusion of the spinal cord, using a modification of the technique of Albin. Motor activity was controlled daily during the course of the next nine postoperation days and scored using Tarlov's system. Spinal cord samples from the impact injury site were taken and frozen in liquid nitrogen. Total lipids were isolated and purified by a modification of the method of Folch. Free fatty acids (FFAs) were separated from the total lipid extract by preparative thin-layer chromatography, converted to the corresponding methyl esters and identified using gas chromatography, using nonadecanoic acid as the internal standard.
Results:
The concentrations of all analysed free fatty acids were increased in the spinal cord after neurotrauma, in comparison to control tissues. Treatment of injured rabbits with indomethacin resulted in a significant decrease in spinal cord FFAs and exerted a positive effect on neurotrauma-induced motor impairment.
Conclusion:
These results indicate a mechanism whereby indomethacin protects rabbits from the sequellae of neuronal damage caused by trauma, and suggests that it may be beneficial in the therapy of neurotrauma.
Sponsorship:
This work was supported by the Croatian Ministry of Science and Technology (project 062019).</description><identifier>ISSN: 1362-4393</identifier><identifier>EISSN: 1476-5624</identifier><identifier>DOI: 10.1038/sj.sc.3101763</identifier><identifier>PMID: 15852057</identifier><identifier>CODEN: SPCOFM</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Anatomy ; Animals ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cerebrospinal fluid. Meninges. Spinal cord ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Models, Animal ; Fatty Acids, Nonesterified - metabolism ; Human Physiology ; Indomethacin - therapeutic use ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Medical sciences ; Motor Activity - drug effects ; Nervous system (semeiology, syndromes) ; Neurochemistry ; Neurology ; Neuropsychology ; Neurosciences ; original-article ; Paraplegia - etiology ; Paraplegia - physiopathology ; Paraplegia - prevention & control ; Rabbits ; Spinal Cord - drug effects ; Spinal Cord - metabolism ; Spinal Cord Injuries - complications ; Spinal Cord Injuries - drug therapy ; Spinal Cord Injuries - physiopathology ; Traumas. Diseases due to physical agents ; Treatment Outcome</subject><ispartof>Spinal cord, 2005-09, Vol.43 (9), p.519-526</ispartof><rights>Springer Nature Limited 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Sep 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-a7434658567a9aa9309a4dee59f89dda4ac2a7699ff7f5eee7ac928a86de6e893</citedby><cites>FETCH-LOGICAL-c514t-a7434658567a9aa9309a4dee59f89dda4ac2a7699ff7f5eee7ac928a86de6e893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17073694$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15852057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PANTOVIC, R</creatorcontrib><creatorcontrib>DRAGANIC, P</creatorcontrib><creatorcontrib>ERAKOVIC, V</creatorcontrib><creatorcontrib>BLAGOVIC, B</creatorcontrib><creatorcontrib>MILIN, C</creatorcontrib><creatorcontrib>SIMONIC, A</creatorcontrib><title>Effect of indomethacin on motor activity and spinal cord free fatty acid content after experimental spinal cord injury in rabbits</title><title>Spinal cord</title><addtitle>Spinal Cord</addtitle><addtitle>Spinal Cord</addtitle><description>Study design:
Determination of functional and biochemical parameters as well as the effect of specific therapies on these parameters, in the experimental model of neurotrauma in rabbits.
Objective:
To assess the effect of indomethacin (0.1–3.0 mg/kg for 9 days), a potent inhibitor of endogenous prostaglandin synthesis, on the motor activity and on the spinal cord tissue concentration of free palmitic, stearic, oleic, arachidonic and docosahexaenoic acids in an experimental model of a spinal cord injury in rabbits.
Setting:
Faculty of Medicine, University of Rijeka, Croatia.
Methods:
The animals were randomly divided into nine experimental groups, four sham and/or vehicle-treated and five indomethacin-treated (including one sham-operated and four injured groups). Laminectomy was followed by contusion of the spinal cord, using a modification of the technique of Albin. Motor activity was controlled daily during the course of the next nine postoperation days and scored using Tarlov's system. Spinal cord samples from the impact injury site were taken and frozen in liquid nitrogen. Total lipids were isolated and purified by a modification of the method of Folch. Free fatty acids (FFAs) were separated from the total lipid extract by preparative thin-layer chromatography, converted to the corresponding methyl esters and identified using gas chromatography, using nonadecanoic acid as the internal standard.
Results:
The concentrations of all analysed free fatty acids were increased in the spinal cord after neurotrauma, in comparison to control tissues. Treatment of injured rabbits with indomethacin resulted in a significant decrease in spinal cord FFAs and exerted a positive effect on neurotrauma-induced motor impairment.
Conclusion:
These results indicate a mechanism whereby indomethacin protects rabbits from the sequellae of neuronal damage caused by trauma, and suggests that it may be beneficial in the therapy of neurotrauma.
Sponsorship:
This work was supported by the Croatian Ministry of Science and Technology (project 062019).</description><subject>Anatomy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease Models, Animal</subject><subject>Fatty Acids, Nonesterified - metabolism</subject><subject>Human Physiology</subject><subject>Indomethacin - therapeutic use</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neuropsychology</subject><subject>Neurosciences</subject><subject>original-article</subject><subject>Paraplegia - etiology</subject><subject>Paraplegia - physiopathology</subject><subject>Paraplegia - prevention & control</subject><subject>Rabbits</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal Cord Injuries - complications</subject><subject>Spinal Cord Injuries - drug therapy</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Treatment Outcome</subject><issn>1362-4393</issn><issn>1476-5624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU2LFDEQhoMo7jp69KgEYb31mHTSSecoy_oBC1703NSkK5qmJxmTtOwc_edmmdYRwUsqVD31VhUvIc8523Im-jd52ma7FZxxrcQDcsmlVk2nWvmw_oVqGymMuCBPcp4YY4ab_jG54F3ftazTl-TnjXNoC42O-jDGPZZvYH2gMdB9LDFRsMX_8OVIIYw0H3yAmdqYRuoSInVQ7kvWjzUZCoZCwRVMFO8OmPy-Jir_d5sP05KONdAEu50v-Sl55GDO-GyNG_Ll3c3n6w_N7af3H6_f3ja247I0oKWQqu6tNBgAI5gBOSJ2xvVmHEGCbUErY5zTrkNEDda0PfRqRIW9ERvy-qR7SPH7grkMe58tzjMEjEseVN9pplpVwVf_gFNcUj0gD21rhJC8PhvSnCCbYs4J3XCo50I6DpwN98YMeRqyHVZjKv9yFV12exzP9OpEBa5WALKF2SUI1uczp5kWysjKbU9crqXwFdN5u_9NfnFqCFCWhH8Uf9d_AXrase8</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>PANTOVIC, R</creator><creator>DRAGANIC, P</creator><creator>ERAKOVIC, V</creator><creator>BLAGOVIC, B</creator><creator>MILIN, C</creator><creator>SIMONIC, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Effect of indomethacin on motor activity and spinal cord free fatty acid content after experimental spinal cord injury in rabbits</title><author>PANTOVIC, R ; DRAGANIC, P ; ERAKOVIC, V ; BLAGOVIC, B ; MILIN, C ; SIMONIC, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-a7434658567a9aa9309a4dee59f89dda4ac2a7699ff7f5eee7ac928a86de6e893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anatomy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cerebrospinal fluid. Meninges. Spinal cord</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease Models, Animal</topic><topic>Fatty Acids, Nonesterified - metabolism</topic><topic>Human Physiology</topic><topic>Indomethacin - therapeutic use</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neuropsychology</topic><topic>Neurosciences</topic><topic>original-article</topic><topic>Paraplegia - etiology</topic><topic>Paraplegia - physiopathology</topic><topic>Paraplegia - prevention & control</topic><topic>Rabbits</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - metabolism</topic><topic>Spinal Cord Injuries - complications</topic><topic>Spinal Cord Injuries - drug therapy</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PANTOVIC, R</creatorcontrib><creatorcontrib>DRAGANIC, P</creatorcontrib><creatorcontrib>ERAKOVIC, V</creatorcontrib><creatorcontrib>BLAGOVIC, B</creatorcontrib><creatorcontrib>MILIN, C</creatorcontrib><creatorcontrib>SIMONIC, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Spinal cord</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PANTOVIC, R</au><au>DRAGANIC, P</au><au>ERAKOVIC, V</au><au>BLAGOVIC, B</au><au>MILIN, C</au><au>SIMONIC, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of indomethacin on motor activity and spinal cord free fatty acid content after experimental spinal cord injury in rabbits</atitle><jtitle>Spinal cord</jtitle><stitle>Spinal Cord</stitle><addtitle>Spinal Cord</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>43</volume><issue>9</issue><spage>519</spage><epage>526</epage><pages>519-526</pages><issn>1362-4393</issn><eissn>1476-5624</eissn><coden>SPCOFM</coden><abstract>Study design:
Determination of functional and biochemical parameters as well as the effect of specific therapies on these parameters, in the experimental model of neurotrauma in rabbits.
Objective:
To assess the effect of indomethacin (0.1–3.0 mg/kg for 9 days), a potent inhibitor of endogenous prostaglandin synthesis, on the motor activity and on the spinal cord tissue concentration of free palmitic, stearic, oleic, arachidonic and docosahexaenoic acids in an experimental model of a spinal cord injury in rabbits.
Setting:
Faculty of Medicine, University of Rijeka, Croatia.
Methods:
The animals were randomly divided into nine experimental groups, four sham and/or vehicle-treated and five indomethacin-treated (including one sham-operated and four injured groups). Laminectomy was followed by contusion of the spinal cord, using a modification of the technique of Albin. Motor activity was controlled daily during the course of the next nine postoperation days and scored using Tarlov's system. Spinal cord samples from the impact injury site were taken and frozen in liquid nitrogen. Total lipids were isolated and purified by a modification of the method of Folch. Free fatty acids (FFAs) were separated from the total lipid extract by preparative thin-layer chromatography, converted to the corresponding methyl esters and identified using gas chromatography, using nonadecanoic acid as the internal standard.
Results:
The concentrations of all analysed free fatty acids were increased in the spinal cord after neurotrauma, in comparison to control tissues. Treatment of injured rabbits with indomethacin resulted in a significant decrease in spinal cord FFAs and exerted a positive effect on neurotrauma-induced motor impairment.
Conclusion:
These results indicate a mechanism whereby indomethacin protects rabbits from the sequellae of neuronal damage caused by trauma, and suggests that it may be beneficial in the therapy of neurotrauma.
Sponsorship:
This work was supported by the Croatian Ministry of Science and Technology (project 062019).</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15852057</pmid><doi>10.1038/sj.sc.3101763</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Spinal cord, 2005-09, Vol.43 (9), p.519-526 |
| issn | 1362-4393 1476-5624 |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | Anatomy Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cerebrospinal fluid. Meninges. Spinal cord Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Fatty Acids, Nonesterified - metabolism Human Physiology Indomethacin - therapeutic use Injuries of the nervous system and the skull. Diseases due to physical agents Medical sciences Motor Activity - drug effects Nervous system (semeiology, syndromes) Neurochemistry Neurology Neuropsychology Neurosciences original-article Paraplegia - etiology Paraplegia - physiopathology Paraplegia - prevention & control Rabbits Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord Injuries - complications Spinal Cord Injuries - drug therapy Spinal Cord Injuries - physiopathology Traumas. Diseases due to physical agents Treatment Outcome |
| title | Effect of indomethacin on motor activity and spinal cord free fatty acid content after experimental spinal cord injury in rabbits |
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