Cord blood rescues stroke-induced changes in splenocyte phenotype and function

The neuroprotective mechanism of human umbilical cord blood cells (HUCBC) in the rat middle cerebral artery occlusion (MCAO) stroke model remains uncertain. Given the inflammatory sequelae that occur following stroke, we investigated whether HUCBC protection could be derived from the modulation of t...

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Veröffentlicht in:	Experimental neurology 2006-05, Vol.199 (1), p.191-200
Hauptverfasser:	Vendrame, Martina, Gemma, Carmelina, Pennypacker, Keith R., Bickford, Paula C., Davis Sanberg, Cyndy, Sanberg, Paul R., Willing, Alison E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8 Antigens - metabolism Cell Proliferation Cells, Cultured Cord Blood Stem Cell Transplantation - methods Cytokines - metabolism Disease Models, Animal Electrophoretic Mobility Shift Assay - methods Enzyme-Linked Immunosorbent Assay - methods Flow Cytometry - methods Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - surgery Male Phenotype Rats Rats, Sprague-Dawley Spleen - metabolism Spleen - pathology Spleen - physiopathology
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