14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5

The voltage-sensitive Na channel Nav1.5 plays a crucial role in generating and propagating the cardiac action potential and its dysfunction promotes cardiac arrhythmias. The channel takes part into a large molecular complex containing regulatory proteins. Thus, factors that modulate its biosynthesis...

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Veröffentlicht in:	Circulation research 2006-06, Vol.98 (12), p.1538-1546
Hauptverfasser:	Allouis, Marie, Le Bouffant, Françoise, Wilders, Ronald, Péroz, David, Schott, Jean-Jacques, Noireaud, Jacques, Le Marec, Hervé, Mérot, Jean, Escande, Denis, Baró, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - chemistry 14-3-3 Proteins - physiology Action Potentials - physiology Animals Biological and medical sciences Cercopithecus aethiops Computer Simulation COS Cells Dimerization Electric Conductivity Electrophysiology Fundamental and applied biological sciences. Psychology Heart - physiology Humans Intracellular Membranes - metabolism Models, Cardiovascular Muscle Proteins - genetics Muscle Proteins - metabolism Muscle Proteins - physiology Myocardium - metabolism NAV1.5 Voltage-Gated Sodium Channel Protein Isoforms - physiology Protein Structure, Tertiary Recombinant Proteins - metabolism Sodium Channels - genetics Sodium Channels - metabolism Sodium Channels - physiology Transfection Vertebrates: cardiovascular system
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