Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone
The antifungal activity of ether extract of Nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of Trichophyton rubrum and one each of Trichophyton interdigitale, Trichophyton mentagrophytes, Epidermophyton floccosum and Microspor...
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| Veröffentlicht in: | Journal of ethnopharmacology 2005-10, Vol.101 (1), p.116-119 |
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| container_title | Journal of ethnopharmacology |
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| creator | Aljabre, Salih Hamad Mohamad Randhawa, Mohamad Akram Akhtar, Naeem Alakloby, Omar Mohamad Alqurashi, Abdulrahman Mohamad Aldossary, Ali |
| description | The antifungal activity of ether extract of
Nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of
Trichophyton rubrum and one each of
Trichophyton interdigitale,
Trichophyton mentagrophytes,
Epidermophyton floccosum and
Microsporum canis. Agar diffusion method with serial dilutions of ether extract of
Nigella sativa, thymoquinone and griseofulvin was employed. The incubation was carried out at 30
°C for 14 days. The diameter of fungal colonies and the percentage inhibition of the fungal growth at each dilution were determined, taking those of the controls as 100%. The minimum inhibitory concentration (MIC) was considered as the minimum concentration of the drug, which inhibited 80–100% of the fungal growth. The MICs of the ether extract of
Nigella sativa and thymoquinone were between 10 and 40 and 0.125 and 0.25
mg/ml, respectively, while those of griseofulvin ranged from 0.00095 to 0.0155
mg/ml. These results denote the potentiality of
Nigella sativa as a source for antidermatophyte drugs and support its use in folk medicine for the treatment of fungal skin infections. |
| doi_str_mv | 10.1016/j.jep.2005.04.002 |
| format | Article |
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Nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of
Trichophyton rubrum and one each of
Trichophyton interdigitale,
Trichophyton mentagrophytes,
Epidermophyton floccosum and
Microsporum canis. Agar diffusion method with serial dilutions of ether extract of
Nigella sativa, thymoquinone and griseofulvin was employed. The incubation was carried out at 30
°C for 14 days. The diameter of fungal colonies and the percentage inhibition of the fungal growth at each dilution were determined, taking those of the controls as 100%. The minimum inhibitory concentration (MIC) was considered as the minimum concentration of the drug, which inhibited 80–100% of the fungal growth. The MICs of the ether extract of
Nigella sativa and thymoquinone were between 10 and 40 and 0.125 and 0.25
mg/ml, respectively, while those of griseofulvin ranged from 0.00095 to 0.0155
mg/ml. These results denote the potentiality of
Nigella sativa as a source for antidermatophyte drugs and support its use in folk medicine for the treatment of fungal skin infections.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2005.04.002</identifier><identifier>PMID: 15908151</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Antifungal Agents - pharmacology ; Antifungal assays ; antifungal properties ; Arthrodermataceae - drug effects ; Benzoquinones - pharmacology ; Biological and medical sciences ; chemical constituents of plants ; Dermatophytes ; Epidermophyton floccosum ; General pharmacology ; Griseofulvin ; keratinophilic fungi ; Medical sciences ; medicinal plants ; medicinal properties ; Microbial Sensitivity Tests ; Microsporum canis ; Nigella sativa ; Nigella sativa - chemistry ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - pharmacology ; quinones ; seeds ; skin diseases ; Thymoquinone ; Tinea ; Trichophyton interdigitale ; Trichophyton mentagrophytes ; Trichophyton rubrum</subject><ispartof>Journal of ethnopharmacology, 2005-10, Vol.101 (1), p.116-119</ispartof><rights>2005</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-b964f2e0c0476ba4ac7bd58178f440426e66338b66fd31929167fdecc3c2e9c53</citedby><cites>FETCH-LOGICAL-c405t-b964f2e0c0476ba4ac7bd58178f440426e66338b66fd31929167fdecc3c2e9c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874105002539$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17117059$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15908151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aljabre, Salih Hamad Mohamad</creatorcontrib><creatorcontrib>Randhawa, Mohamad Akram</creatorcontrib><creatorcontrib>Akhtar, Naeem</creatorcontrib><creatorcontrib>Alakloby, Omar Mohamad</creatorcontrib><creatorcontrib>Alqurashi, Abdulrahman Mohamad</creatorcontrib><creatorcontrib>Aldossary, Ali</creatorcontrib><title>Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The antifungal activity of ether extract of
Nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of
Trichophyton rubrum and one each of
Trichophyton interdigitale,
Trichophyton mentagrophytes,
Epidermophyton floccosum and
Microsporum canis. Agar diffusion method with serial dilutions of ether extract of
Nigella sativa, thymoquinone and griseofulvin was employed. The incubation was carried out at 30
°C for 14 days. The diameter of fungal colonies and the percentage inhibition of the fungal growth at each dilution were determined, taking those of the controls as 100%. The minimum inhibitory concentration (MIC) was considered as the minimum concentration of the drug, which inhibited 80–100% of the fungal growth. The MICs of the ether extract of
Nigella sativa and thymoquinone were between 10 and 40 and 0.125 and 0.25
mg/ml, respectively, while those of griseofulvin ranged from 0.00095 to 0.0155
mg/ml. These results denote the potentiality of
Nigella sativa as a source for antidermatophyte drugs and support its use in folk medicine for the treatment of fungal skin infections.</description><subject>Antifungal Agents - pharmacology</subject><subject>Antifungal assays</subject><subject>antifungal properties</subject><subject>Arthrodermataceae - drug effects</subject><subject>Benzoquinones - pharmacology</subject><subject>Biological and medical sciences</subject><subject>chemical constituents of plants</subject><subject>Dermatophytes</subject><subject>Epidermophyton floccosum</subject><subject>General pharmacology</subject><subject>Griseofulvin</subject><subject>keratinophilic fungi</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Microbial Sensitivity Tests</subject><subject>Microsporum canis</subject><subject>Nigella sativa</subject><subject>Nigella sativa - chemistry</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>quinones</subject><subject>seeds</subject><subject>skin diseases</subject><subject>Thymoquinone</subject><subject>Tinea</subject><subject>Trichophyton interdigitale</subject><subject>Trichophyton mentagrophytes</subject><subject>Trichophyton rubrum</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EotvCD-ACudATCWPHXxGnqiofUkUP0LPlOJOuV_nC9lbdf1-vslJvnEYaPe_Mq4eQDxQqClR-3VU7XCoGICrgFQB7RTZUK1YqoerXZAO10qVWnJ6R8xh3AKAoh7fkjIoGNBV0Q9zVlHyHYbRpXraHhIV1yT_6dCjmvsC0xVDgUwp5e1z89g84DLaINkO2sFNX-BTXDBZL8JPzy4BfirQ9jPO_vZ_mCd-RN70dIr4_zQty__3m7_XP8vbux6_rq9vScRCpbBvJe4bggCvZWm6dajuhqdI958CZRCnrWrdS9l1NG9ZQqfoOnasdw8aJ-oJcrneXkF9jTGb00R37Tjjvo5FaKGCgMkhX0IU5xoC9yc1HGw6GgjmaNTuTzZqjWQPcZLM58_F0fN-O2L0kTioz8PkE2Ojs0AebXcQXTlGqQDSZ-7RyvZ2NfQiZuf_DgNZAoeagZSa-rQRmWY8eg4nO4-Sw8wFdMt3s_1P0GSAooEs</recordid><startdate>20051003</startdate><enddate>20051003</enddate><creator>Aljabre, Salih Hamad Mohamad</creator><creator>Randhawa, Mohamad Akram</creator><creator>Akhtar, Naeem</creator><creator>Alakloby, Omar Mohamad</creator><creator>Alqurashi, Abdulrahman Mohamad</creator><creator>Aldossary, Ali</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051003</creationdate><title>Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone</title><author>Aljabre, Salih Hamad Mohamad ; Randhawa, Mohamad Akram ; Akhtar, Naeem ; Alakloby, Omar Mohamad ; Alqurashi, Abdulrahman Mohamad ; Aldossary, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-b964f2e0c0476ba4ac7bd58178f440426e66338b66fd31929167fdecc3c2e9c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Antifungal Agents - pharmacology</topic><topic>Antifungal assays</topic><topic>antifungal properties</topic><topic>Arthrodermataceae - drug effects</topic><topic>Benzoquinones - pharmacology</topic><topic>Biological and medical sciences</topic><topic>chemical constituents of plants</topic><topic>Dermatophytes</topic><topic>Epidermophyton floccosum</topic><topic>General pharmacology</topic><topic>Griseofulvin</topic><topic>keratinophilic fungi</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Microbial Sensitivity Tests</topic><topic>Microsporum canis</topic><topic>Nigella sativa</topic><topic>Nigella sativa - chemistry</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>quinones</topic><topic>seeds</topic><topic>skin diseases</topic><topic>Thymoquinone</topic><topic>Tinea</topic><topic>Trichophyton interdigitale</topic><topic>Trichophyton mentagrophytes</topic><topic>Trichophyton rubrum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aljabre, Salih Hamad Mohamad</creatorcontrib><creatorcontrib>Randhawa, Mohamad Akram</creatorcontrib><creatorcontrib>Akhtar, Naeem</creatorcontrib><creatorcontrib>Alakloby, Omar Mohamad</creatorcontrib><creatorcontrib>Alqurashi, Abdulrahman Mohamad</creatorcontrib><creatorcontrib>Aldossary, Ali</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aljabre, Salih Hamad Mohamad</au><au>Randhawa, Mohamad Akram</au><au>Akhtar, Naeem</au><au>Alakloby, Omar Mohamad</au><au>Alqurashi, Abdulrahman Mohamad</au><au>Aldossary, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2005-10-03</date><risdate>2005</risdate><volume>101</volume><issue>1</issue><spage>116</spage><epage>119</epage><pages>116-119</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The antifungal activity of ether extract of
Nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of
Trichophyton rubrum and one each of
Trichophyton interdigitale,
Trichophyton mentagrophytes,
Epidermophyton floccosum and
Microsporum canis. Agar diffusion method with serial dilutions of ether extract of
Nigella sativa, thymoquinone and griseofulvin was employed. The incubation was carried out at 30
°C for 14 days. The diameter of fungal colonies and the percentage inhibition of the fungal growth at each dilution were determined, taking those of the controls as 100%. The minimum inhibitory concentration (MIC) was considered as the minimum concentration of the drug, which inhibited 80–100% of the fungal growth. The MICs of the ether extract of
Nigella sativa and thymoquinone were between 10 and 40 and 0.125 and 0.25
mg/ml, respectively, while those of griseofulvin ranged from 0.00095 to 0.0155
mg/ml. These results denote the potentiality of
Nigella sativa as a source for antidermatophyte drugs and support its use in folk medicine for the treatment of fungal skin infections.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15908151</pmid><doi>10.1016/j.jep.2005.04.002</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2005-10, Vol.101 (1), p.116-119 |
| issn | 0378-8741 1872-7573 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antifungal Agents - pharmacology Antifungal assays antifungal properties Arthrodermataceae - drug effects Benzoquinones - pharmacology Biological and medical sciences chemical constituents of plants Dermatophytes Epidermophyton floccosum General pharmacology Griseofulvin keratinophilic fungi Medical sciences medicinal plants medicinal properties Microbial Sensitivity Tests Microsporum canis Nigella sativa Nigella sativa - chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - pharmacology quinones seeds skin diseases Thymoquinone Tinea Trichophyton interdigitale Trichophyton mentagrophytes Trichophyton rubrum |
| title | Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone |
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