No Association Between ACE I/D Polymorphism and Cardiovascular Hemodynamics During Exercise in Young Women
Abstract The ACE I/D polymorphism has been shown to interact with habitual physical activity levels in postmenopausal women to associate with submaximal and with maximal exercise hemodynamics. This investigation was designed to assess the potential relationships between ACE genotype and oxygen consu...
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| Veröffentlicht in: | International journal of sports medicine 2005-10, Vol.26 (8), p.638-644 |
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| container_title | International journal of sports medicine |
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| creator | Roltsch, M. H. Brown, M. D. Hand, B. D. Kostek, M. C. Phares, D. A. Huberty, A. Douglass, L. W. Ferrell, R. E. Hagberg, J. M. |
| description | Abstract
The ACE I/D polymorphism has been shown to interact with habitual physical activity levels in postmenopausal women to associate with submaximal and with maximal exercise hemodynamics. This investigation was designed to assess the potential relationships between ACE genotype and oxygen consumption (VO
2
), cardiac output (Q), stroke volume (SV), heart rate (HR), blood pressure (BP), total peripheral resistance (TPR), and arteriovenous oxygen difference ([a-v]O
2
diff) during submaximal and maximal exercise in young sedentary and endurance-trained women. Seventy-seven 18 - 35-yr-old women underwent a maximal exercise test and a number of cardiac output tests on a treadmill using the acetylene rebreathing technique. ACE genotype was not significantly associated with VO
2max
(II 41.4 ± 1.2, ID 39.8 ± 0.9, DD 39.8 ± 1.1 ml/kg/min, p = ns) or maximal HR (II 191 ± 2, ID 191 ± 1, DD 193 ± 2 bpm, p = ns). In addition, systolic and diastolic BP, (a-v)O
2
diff, TPR, SV, and Q during maximal exercise were not significantly associated with ACE genotype. During submaximal exercise, SBP, Q, SV, HR, TPR, and (a-v)O
2
diff were not significantly associated with ACE genotype. However, the association between diastolic BP during submaximal exercise and ACE genotype approached significance (p = 0.08). In addition, there were no statistically significant interactions between ACE genotype and habitual physical activity (PA) levels for any of the submaximal or the maximal exercise hemodynamic variables. We conclude that the ACE I/D polymorphism was not associated, independently or interacting with habitual PA levels, submaximal, or maximal cardiovascular hemodynamics in young women. |
| doi_str_mv | 10.1055/s-2004-830436 |
| format | Article |
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The ACE I/D polymorphism has been shown to interact with habitual physical activity levels in postmenopausal women to associate with submaximal and with maximal exercise hemodynamics. This investigation was designed to assess the potential relationships between ACE genotype and oxygen consumption (VO
2
), cardiac output (Q), stroke volume (SV), heart rate (HR), blood pressure (BP), total peripheral resistance (TPR), and arteriovenous oxygen difference ([a-v]O
2
diff) during submaximal and maximal exercise in young sedentary and endurance-trained women. Seventy-seven 18 - 35-yr-old women underwent a maximal exercise test and a number of cardiac output tests on a treadmill using the acetylene rebreathing technique. ACE genotype was not significantly associated with VO
2max
(II 41.4 ± 1.2, ID 39.8 ± 0.9, DD 39.8 ± 1.1 ml/kg/min, p = ns) or maximal HR (II 191 ± 2, ID 191 ± 1, DD 193 ± 2 bpm, p = ns). In addition, systolic and diastolic BP, (a-v)O
2
diff, TPR, SV, and Q during maximal exercise were not significantly associated with ACE genotype. During submaximal exercise, SBP, Q, SV, HR, TPR, and (a-v)O
2
diff were not significantly associated with ACE genotype. However, the association between diastolic BP during submaximal exercise and ACE genotype approached significance (p = 0.08). In addition, there were no statistically significant interactions between ACE genotype and habitual physical activity (PA) levels for any of the submaximal or the maximal exercise hemodynamic variables. We conclude that the ACE I/D polymorphism was not associated, independently or interacting with habitual PA levels, submaximal, or maximal cardiovascular hemodynamics in young women.</description><identifier>ISSN: 0172-4622</identifier><identifier>EISSN: 1439-3964</identifier><identifier>DOI: 10.1055/s-2004-830436</identifier><identifier>PMID: 16158368</identifier><identifier>CODEN: IJSMDA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cardiac Output - physiology ; Exercise - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Variation - physiology ; Genotype ; Heart Rate - physiology ; Hemodynamics ; Humans ; Oxygen Consumption - physiology ; Peptidyl-Dipeptidase A - genetics ; Physiology & Biochemistry ; Polymorphism, Genetic - physiology ; Stroke Volume - physiology ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>International journal of sports medicine, 2005-10, Vol.26 (8), p.638-644</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2666-3e7aa9b6ebaa0559303250c273dc0901a4bce66b32e344b6262ec197de887cef3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2004-830436.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2004-830436$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3018,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17149874$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16158368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roltsch, M. H.</creatorcontrib><creatorcontrib>Brown, M. D.</creatorcontrib><creatorcontrib>Hand, B. D.</creatorcontrib><creatorcontrib>Kostek, M. C.</creatorcontrib><creatorcontrib>Phares, D. A.</creatorcontrib><creatorcontrib>Huberty, A.</creatorcontrib><creatorcontrib>Douglass, L. W.</creatorcontrib><creatorcontrib>Ferrell, R. E.</creatorcontrib><creatorcontrib>Hagberg, J. M.</creatorcontrib><title>No Association Between ACE I/D Polymorphism and Cardiovascular Hemodynamics During Exercise in Young Women</title><title>International journal of sports medicine</title><addtitle>Int J Sports Med</addtitle><description>Abstract
The ACE I/D polymorphism has been shown to interact with habitual physical activity levels in postmenopausal women to associate with submaximal and with maximal exercise hemodynamics. This investigation was designed to assess the potential relationships between ACE genotype and oxygen consumption (VO
2
), cardiac output (Q), stroke volume (SV), heart rate (HR), blood pressure (BP), total peripheral resistance (TPR), and arteriovenous oxygen difference ([a-v]O
2
diff) during submaximal and maximal exercise in young sedentary and endurance-trained women. Seventy-seven 18 - 35-yr-old women underwent a maximal exercise test and a number of cardiac output tests on a treadmill using the acetylene rebreathing technique. ACE genotype was not significantly associated with VO
2max
(II 41.4 ± 1.2, ID 39.8 ± 0.9, DD 39.8 ± 1.1 ml/kg/min, p = ns) or maximal HR (II 191 ± 2, ID 191 ± 1, DD 193 ± 2 bpm, p = ns). In addition, systolic and diastolic BP, (a-v)O
2
diff, TPR, SV, and Q during maximal exercise were not significantly associated with ACE genotype. During submaximal exercise, SBP, Q, SV, HR, TPR, and (a-v)O
2
diff were not significantly associated with ACE genotype. However, the association between diastolic BP during submaximal exercise and ACE genotype approached significance (p = 0.08). In addition, there were no statistically significant interactions between ACE genotype and habitual physical activity (PA) levels for any of the submaximal or the maximal exercise hemodynamic variables. We conclude that the ACE I/D polymorphism was not associated, independently or interacting with habitual PA levels, submaximal, or maximal cardiovascular hemodynamics in young women.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cardiac Output - physiology</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation - physiology</subject><subject>Genotype</subject><subject>Heart Rate - physiology</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Oxygen Consumption - physiology</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Physiology & Biochemistry</subject><subject>Polymorphism, Genetic - physiology</subject><subject>Stroke Volume - physiology</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><issn>0172-4622</issn><issn>1439-3964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi1ERUPgyBX5Aie29dd67WNIQ1upAg6tECfL651QR2s72FlK_j2ukqpHTiONHr2jeV6E3lFyRknbnpeGESIaxYng8gWaUcF1w7UUL9GM0I41QjJ2il6XsiGECk35K3RKJW0Vl2qGNl8TXpSSnLc7nyL-DLsHgIgXyxW-Pr_A39O4Dylv730J2MYBL20efPpji5tGm_EVhDTsow3eFXwxZR9_4dVfyM4XwD7in2mqmx8pQHyDTtZ2LPD2OOfo7svqdnnV3Hy7vF4ubhrHpJQNh85a3Uvora0Pak44a4ljHR8c0YRa0TuQsucMuBC9ZJKBo7obQKnOwZrP0cdD7jan3xOUnQm-OBhHGyFNxUjVSk2U-i9INdOdrIfn6P0RnPoAg9lmH2zemyeNFfhwBKoXO66zjVXAM9dV8aoTlft04Hb3HgKYTZpyrC4MJeaxTVPMY5vm0Cb_B8BGjkU</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Roltsch, M. H.</creator><creator>Brown, M. D.</creator><creator>Hand, B. D.</creator><creator>Kostek, M. C.</creator><creator>Phares, D. A.</creator><creator>Huberty, A.</creator><creator>Douglass, L. W.</creator><creator>Ferrell, R. E.</creator><creator>Hagberg, J. M.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>No Association Between ACE I/D Polymorphism and Cardiovascular Hemodynamics During Exercise in Young Women</title><author>Roltsch, M. H. ; Brown, M. D. ; Hand, B. D. ; Kostek, M. C. ; Phares, D. A. ; Huberty, A. ; Douglass, L. W. ; Ferrell, R. E. ; Hagberg, J. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2666-3e7aa9b6ebaa0559303250c273dc0901a4bce66b32e344b6262ec197de887cef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cardiac Output - physiology</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Variation - physiology</topic><topic>Genotype</topic><topic>Heart Rate - physiology</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Oxygen Consumption - physiology</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Physiology & Biochemistry</topic><topic>Polymorphism, Genetic - physiology</topic><topic>Stroke Volume - physiology</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roltsch, M. H.</creatorcontrib><creatorcontrib>Brown, M. D.</creatorcontrib><creatorcontrib>Hand, B. D.</creatorcontrib><creatorcontrib>Kostek, M. C.</creatorcontrib><creatorcontrib>Phares, D. A.</creatorcontrib><creatorcontrib>Huberty, A.</creatorcontrib><creatorcontrib>Douglass, L. W.</creatorcontrib><creatorcontrib>Ferrell, R. E.</creatorcontrib><creatorcontrib>Hagberg, J. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No Association Between ACE I/D Polymorphism and Cardiovascular Hemodynamics During Exercise in Young Women</atitle><jtitle>International journal of sports medicine</jtitle><addtitle>Int J Sports Med</addtitle><date>2005-10</date><risdate>2005</risdate><volume>26</volume><issue>8</issue><spage>638</spage><epage>644</epage><pages>638-644</pages><issn>0172-4622</issn><eissn>1439-3964</eissn><coden>IJSMDA</coden><abstract>Abstract
The ACE I/D polymorphism has been shown to interact with habitual physical activity levels in postmenopausal women to associate with submaximal and with maximal exercise hemodynamics. This investigation was designed to assess the potential relationships between ACE genotype and oxygen consumption (VO
2
), cardiac output (Q), stroke volume (SV), heart rate (HR), blood pressure (BP), total peripheral resistance (TPR), and arteriovenous oxygen difference ([a-v]O
2
diff) during submaximal and maximal exercise in young sedentary and endurance-trained women. Seventy-seven 18 - 35-yr-old women underwent a maximal exercise test and a number of cardiac output tests on a treadmill using the acetylene rebreathing technique. ACE genotype was not significantly associated with VO
2max
(II 41.4 ± 1.2, ID 39.8 ± 0.9, DD 39.8 ± 1.1 ml/kg/min, p = ns) or maximal HR (II 191 ± 2, ID 191 ± 1, DD 193 ± 2 bpm, p = ns). In addition, systolic and diastolic BP, (a-v)O
2
diff, TPR, SV, and Q during maximal exercise were not significantly associated with ACE genotype. During submaximal exercise, SBP, Q, SV, HR, TPR, and (a-v)O
2
diff were not significantly associated with ACE genotype. However, the association between diastolic BP during submaximal exercise and ACE genotype approached significance (p = 0.08). In addition, there were no statistically significant interactions between ACE genotype and habitual physical activity (PA) levels for any of the submaximal or the maximal exercise hemodynamic variables. We conclude that the ACE I/D polymorphism was not associated, independently or interacting with habitual PA levels, submaximal, or maximal cardiovascular hemodynamics in young women.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>16158368</pmid><doi>10.1055/s-2004-830436</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of sports medicine, 2005-10, Vol.26 (8), p.638-644 |
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| subjects | Adolescent Adult Biological and medical sciences Cardiac Output - physiology Exercise - physiology Female Fundamental and applied biological sciences. Psychology Genetic Variation - physiology Genotype Heart Rate - physiology Hemodynamics Humans Oxygen Consumption - physiology Peptidyl-Dipeptidase A - genetics Physiology & Biochemistry Polymorphism, Genetic - physiology Stroke Volume - physiology Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | No Association Between ACE I/D Polymorphism and Cardiovascular Hemodynamics During Exercise in Young Women |
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