Effects of Low Birth Weight in 8- to 13-Year-Old Children: Implications in Endothelial Function and Uric Acid Levels
Low birth weight has been associated with an increased incidence of adult cardiovascular disease. Endothelial dysfunction and high levels of serum uric acid are associated with hypertension. In this study, we have determined whether uric acid is related to blood pressure and vascular function in chi...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2006-07, Vol.48 (1), p.45-50 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Franco, Maria C.P Christofalo, Dejaldo M.J Sawaya, Ana Lydia Ajzen, Sérgio A Sesso, Ricardo |
| description | Low birth weight has been associated with an increased incidence of adult cardiovascular disease. Endothelial dysfunction and high levels of serum uric acid are associated with hypertension. In this study, we have determined whether uric acid is related to blood pressure and vascular function in children with low birth weight. We evaluated vascular function using high-resolution ultrasound, blood pressure, and uric acid levels in 78 children (35 girls, 43 boys, aged 8 to 13 years). Increasing levels of uric acid and systolic blood pressure were observed in children with low birth weight. Birth weight was inversely associated with both systolic blood pressure and uric acid; on the other hand, uric acid levels were directly correlated with systolic blood pressure in children of the entire cohort. Low birth weight was associated with reduced flow-mediated dilation (r=0.427, P |
| doi_str_mv | 10.1161/01.HYP.0000223446.49596.3a |
| format | Article |
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Endothelial dysfunction and high levels of serum uric acid are associated with hypertension. In this study, we have determined whether uric acid is related to blood pressure and vascular function in children with low birth weight. We evaluated vascular function using high-resolution ultrasound, blood pressure, and uric acid levels in 78 children (35 girls, 43 boys, aged 8 to 13 years). Increasing levels of uric acid and systolic blood pressure were observed in children with low birth weight. Birth weight was inversely associated with both systolic blood pressure and uric acid; on the other hand, uric acid levels were directly correlated with systolic blood pressure in children of the entire cohort. Low birth weight was associated with reduced flow-mediated dilation (r=0.427, P<0.001). Because the children with low birth weight had elevated uric acid as well as higher systolic blood pressure levels, we evaluated the correlation between these variables. In the low birth weight group, multiple regression analysis revealed that uric acid (β=−2.886; SE=1.393; P=0.040) had a graded inverse relationship with flow-mediated dilation, which was not affected in a model adjusting for race and gender. We conclude that children with a history of low birth weight show impaired endothelial function and increased blood pressure and uric acid levels. These findings may be early expressions of vascular compromise, contributing to susceptibility to disease in adult life.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.0000223446.49596.3a</identifier><identifier>PMID: 16682609</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adolescent ; Antihypertensive agents ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Body Size ; Brachial Artery - diagnostic imaging ; Brachial Artery - physiology ; Cardiology. Vascular system ; Cardiovascular system ; Child ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Endothelium, Vascular - diagnostic imaging ; Endothelium, Vascular - physiology ; Female ; Follow-Up Studies ; Humans ; Hypertension - diagnosis ; Hypertension - etiology ; Infant, Low Birth Weight - physiology ; Infant, Newborn ; Linear Models ; Lipids - blood ; Male ; Medical sciences ; Pharmacology. 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Endothelial dysfunction and high levels of serum uric acid are associated with hypertension. In this study, we have determined whether uric acid is related to blood pressure and vascular function in children with low birth weight. We evaluated vascular function using high-resolution ultrasound, blood pressure, and uric acid levels in 78 children (35 girls, 43 boys, aged 8 to 13 years). Increasing levels of uric acid and systolic blood pressure were observed in children with low birth weight. Birth weight was inversely associated with both systolic blood pressure and uric acid; on the other hand, uric acid levels were directly correlated with systolic blood pressure in children of the entire cohort. Low birth weight was associated with reduced flow-mediated dilation (r=0.427, P<0.001). Because the children with low birth weight had elevated uric acid as well as higher systolic blood pressure levels, we evaluated the correlation between these variables. In the low birth weight group, multiple regression analysis revealed that uric acid (β=−2.886; SE=1.393; P=0.040) had a graded inverse relationship with flow-mediated dilation, which was not affected in a model adjusting for race and gender. We conclude that children with a history of low birth weight show impaired endothelial function and increased blood pressure and uric acid levels. These findings may be early expressions of vascular compromise, contributing to susceptibility to disease in adult life.</description><subject>Adolescent</subject><subject>Antihypertensive agents</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Body Size</subject><subject>Brachial Artery - diagnostic imaging</subject><subject>Brachial Artery - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Child</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Endothelium, Vascular - diagnostic imaging</subject><subject>Endothelium, Vascular - physiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - etiology</subject><subject>Infant, Low Birth Weight - physiology</subject><subject>Infant, Newborn</subject><subject>Linear Models</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Risk Factors</subject><subject>Ultrasonography</subject><subject>Uric Acid - blood</subject><subject>Vasodilation</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtvEzEQgFcIREPhLyALCW67-L12byVKaaVI5UAFPVmOPcsanN3U9hLx79k0kTLSaA7zzUNfVX0guCFEks-YNLeP3xo8B6WMc9lwLbRsmH1RLYigvOZCspfVAhPNa03Iz4vqTc6_MSac8_Z1dUGkVFRivajKquvAlYzGDq3HPfoSUunRDwi_-oLCgFSNyogIqx_Bpvo-erTsQ_QJhit0t93F4GwJ45AP7GrwY-khBhvRzTS4QwPZwaOHFBy6dsGjNfyFmN9WrzobM7w71cvq4Wb1fXlbr--_3i2v17VjraC13zCFvRSdw1oT3TLFgWLwbMOZEEqrWQZoJkUrCe60Fx6UBqc3xOHOy45dVp-Oe3dpfJogF7MN2UGMdoBxykYqIdsW4xm8OoIujTkn6Mwuha1N_wzB5uDcYGJm5-bs3Dw7N8zOw-9PV6bNFvx59CR5Bj6eAJudjV2ygwv5zLWaatWqmeNHbj_GAin_idMekunBxtI_n-ZUqppiLPH8Na7nJJT9Bz8_mHE</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>Franco, Maria C.P</creator><creator>Christofalo, Dejaldo M.J</creator><creator>Sawaya, Ana Lydia</creator><creator>Ajzen, Sérgio A</creator><creator>Sesso, Ricardo</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Effects of Low Birth Weight in 8- to 13-Year-Old Children: Implications in Endothelial Function and Uric Acid Levels</title><author>Franco, Maria C.P ; Christofalo, Dejaldo M.J ; Sawaya, Ana Lydia ; Ajzen, Sérgio A ; Sesso, Ricardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3752-db380d65fc099197384e20ed3b4355898161e93657610f9d5de89ec9b1c0fd6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Antihypertensive agents</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure</topic><topic>Body Size</topic><topic>Brachial Artery - diagnostic imaging</topic><topic>Brachial Artery - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Child</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Endothelium, Vascular - diagnostic imaging</topic><topic>Endothelium, Vascular - physiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - etiology</topic><topic>Infant, Low Birth Weight - physiology</topic><topic>Infant, Newborn</topic><topic>Linear Models</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Risk Factors</topic><topic>Ultrasonography</topic><topic>Uric Acid - blood</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franco, Maria C.P</creatorcontrib><creatorcontrib>Christofalo, Dejaldo M.J</creatorcontrib><creatorcontrib>Sawaya, Ana Lydia</creatorcontrib><creatorcontrib>Ajzen, Sérgio A</creatorcontrib><creatorcontrib>Sesso, Ricardo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franco, Maria C.P</au><au>Christofalo, Dejaldo M.J</au><au>Sawaya, Ana Lydia</au><au>Ajzen, Sérgio A</au><au>Sesso, Ricardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Low Birth Weight in 8- to 13-Year-Old Children: Implications in Endothelial Function and Uric Acid Levels</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2006-07</date><risdate>2006</risdate><volume>48</volume><issue>1</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Low birth weight has been associated with an increased incidence of adult cardiovascular disease. Endothelial dysfunction and high levels of serum uric acid are associated with hypertension. In this study, we have determined whether uric acid is related to blood pressure and vascular function in children with low birth weight. We evaluated vascular function using high-resolution ultrasound, blood pressure, and uric acid levels in 78 children (35 girls, 43 boys, aged 8 to 13 years). Increasing levels of uric acid and systolic blood pressure were observed in children with low birth weight. Birth weight was inversely associated with both systolic blood pressure and uric acid; on the other hand, uric acid levels were directly correlated with systolic blood pressure in children of the entire cohort. Low birth weight was associated with reduced flow-mediated dilation (r=0.427, P<0.001). Because the children with low birth weight had elevated uric acid as well as higher systolic blood pressure levels, we evaluated the correlation between these variables. In the low birth weight group, multiple regression analysis revealed that uric acid (β=−2.886; SE=1.393; P=0.040) had a graded inverse relationship with flow-mediated dilation, which was not affected in a model adjusting for race and gender. We conclude that children with a history of low birth weight show impaired endothelial function and increased blood pressure and uric acid levels. These findings may be early expressions of vascular compromise, contributing to susceptibility to disease in adult life.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>16682609</pmid><doi>10.1161/01.HYP.0000223446.49596.3a</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Antihypertensive agents Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure Body Size Brachial Artery - diagnostic imaging Brachial Artery - physiology Cardiology. Vascular system Cardiovascular system Child Clinical manifestations. Epidemiology. Investigative techniques. Etiology Endothelium, Vascular - diagnostic imaging Endothelium, Vascular - physiology Female Follow-Up Studies Humans Hypertension - diagnosis Hypertension - etiology Infant, Low Birth Weight - physiology Infant, Newborn Linear Models Lipids - blood Male Medical sciences Pharmacology. Drug treatments Risk Factors Ultrasonography Uric Acid - blood Vasodilation |
| title | Effects of Low Birth Weight in 8- to 13-Year-Old Children: Implications in Endothelial Function and Uric Acid Levels |
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