Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice
Summary Background Rumex japonicus Houtt. (RJH) is one of the herbs used in Eastern countries for the treatment of atopic dermatitis (AD). It has been shown to have an antioxidative effect in human skin disease. Objectives To examine whether RJH extract (RJH‐E) suppresses the development of AD‐lik...
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| Veröffentlicht in: | British journal of dermatology (1951) 2006-07, Vol.155 (1), p.33-38 |
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| container_title | British journal of dermatology (1951) |
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| creator | Lee, H-S. Kim, S-K. Han, J-B. Choi, H-M. Park, J-H. Kim, E-C. Choi, M-S. An, H-J. Um, J-Y. Kim, H-M. Min, B-I. |
| description | Summary
Background Rumex japonicus Houtt. (RJH) is one of the herbs used in Eastern countries for the treatment of atopic dermatitis (AD). It has been shown to have an antioxidative effect in human skin disease.
Objectives To examine whether RJH extract (RJH‐E) suppresses the development of AD‐like skin lesions in NC/Nga mice, which are induced by the repeated application of picryl chloride (PC).
Methods The efficacy of RJH‐E in NC/Nga mice was assessed by measuring symptom severity, scratching behaviour, Staphylococcus aureus numbers on an ear, and serum levels of IgE, interleukin (IL)‐4 and interferon (IFN)‐γ.
Results Oral administration of RJH‐E to NC/Nga mice treated with PC inhibited the development of AD‐like skin lesions as exemplified by a significant decrease in total skin symptom severity scores, and a decrease in hypertrophy, hyperkeratosis and infiltration of inflammatory cells in the skin. The scratching behaviour and numbers of S. aureus, which are known to be exacerbated in AD, were also significantly reduced by RJH‐E. No significant change was observed in the serum levels of IFN‐γ, whereas IgE and IL‐4 levels were significantly reduced by RJH‐E.
Conclusions These results suggest that RJH‐E inhibits the development of AD‐like skin lesions in NC/Nga mice by suppressing the T‐helper 2 cell response. Our results indicate that RJH treatment could provide an effective alternative therapy for the management of AD. |
| doi_str_mv | 10.1111/j.1365-2133.2006.07303.x |
| format | Article |
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Background Rumex japonicus Houtt. (RJH) is one of the herbs used in Eastern countries for the treatment of atopic dermatitis (AD). It has been shown to have an antioxidative effect in human skin disease.
Objectives To examine whether RJH extract (RJH‐E) suppresses the development of AD‐like skin lesions in NC/Nga mice, which are induced by the repeated application of picryl chloride (PC).
Methods The efficacy of RJH‐E in NC/Nga mice was assessed by measuring symptom severity, scratching behaviour, Staphylococcus aureus numbers on an ear, and serum levels of IgE, interleukin (IL)‐4 and interferon (IFN)‐γ.
Results Oral administration of RJH‐E to NC/Nga mice treated with PC inhibited the development of AD‐like skin lesions as exemplified by a significant decrease in total skin symptom severity scores, and a decrease in hypertrophy, hyperkeratosis and infiltration of inflammatory cells in the skin. The scratching behaviour and numbers of S. aureus, which are known to be exacerbated in AD, were also significantly reduced by RJH‐E. No significant change was observed in the serum levels of IFN‐γ, whereas IgE and IL‐4 levels were significantly reduced by RJH‐E.
Conclusions These results suggest that RJH‐E inhibits the development of AD‐like skin lesions in NC/Nga mice by suppressing the T‐helper 2 cell response. Our results indicate that RJH treatment could provide an effective alternative therapy for the management of AD.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2006.07303.x</identifier><identifier>PMID: 16792749</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Allergic diseases ; Animals ; atopic dermatitis ; Biological and medical sciences ; Dermatitis, Atopic - drug therapy ; Dermatitis, Atopic - immunology ; Dermatitis, Atopic - microbiology ; Dermatology ; Female ; IgE ; Immunoglobulin E - blood ; Immunopathology ; Interferon-gamma - blood ; interferon-γ ; interleukin-4 ; Interleukin-4 - blood ; Liver Function Tests ; Medical sciences ; Mice ; Mice, Mutant Strains ; Models, Animal ; NC/Nga mice ; Phytotherapy - methods ; Picryl Chloride ; Plant Extracts - therapeutic use ; Plant Roots ; Plants, Medicinal ; Rumex ; Rumex japonicus Houtt ; Skin - drug effects ; Skin allergic diseases. Stinging insect allergies ; Staphylococcal Infections - complications ; Staphylococcal Infections - drug therapy ; Staphylococcus aureus - isolation & purification ; Treatment Outcome</subject><ispartof>British journal of dermatology (1951), 2006-07, Vol.155 (1), p.33-38</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3863-d1c3de016c0de87aa61328d93d273e44be01549c401ea4295d8007c1994077de3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2006.07303.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2006.07303.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17848242$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16792749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, H-S.</creatorcontrib><creatorcontrib>Kim, S-K.</creatorcontrib><creatorcontrib>Han, J-B.</creatorcontrib><creatorcontrib>Choi, H-M.</creatorcontrib><creatorcontrib>Park, J-H.</creatorcontrib><creatorcontrib>Kim, E-C.</creatorcontrib><creatorcontrib>Choi, M-S.</creatorcontrib><creatorcontrib>An, H-J.</creatorcontrib><creatorcontrib>Um, J-Y.</creatorcontrib><creatorcontrib>Kim, H-M.</creatorcontrib><creatorcontrib>Min, B-I.</creatorcontrib><title>Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Rumex japonicus Houtt. (RJH) is one of the herbs used in Eastern countries for the treatment of atopic dermatitis (AD). It has been shown to have an antioxidative effect in human skin disease.
Objectives To examine whether RJH extract (RJH‐E) suppresses the development of AD‐like skin lesions in NC/Nga mice, which are induced by the repeated application of picryl chloride (PC).
Methods The efficacy of RJH‐E in NC/Nga mice was assessed by measuring symptom severity, scratching behaviour, Staphylococcus aureus numbers on an ear, and serum levels of IgE, interleukin (IL)‐4 and interferon (IFN)‐γ.
Results Oral administration of RJH‐E to NC/Nga mice treated with PC inhibited the development of AD‐like skin lesions as exemplified by a significant decrease in total skin symptom severity scores, and a decrease in hypertrophy, hyperkeratosis and infiltration of inflammatory cells in the skin. The scratching behaviour and numbers of S. aureus, which are known to be exacerbated in AD, were also significantly reduced by RJH‐E. No significant change was observed in the serum levels of IFN‐γ, whereas IgE and IL‐4 levels were significantly reduced by RJH‐E.
Conclusions These results suggest that RJH‐E inhibits the development of AD‐like skin lesions in NC/Nga mice by suppressing the T‐helper 2 cell response. Our results indicate that RJH treatment could provide an effective alternative therapy for the management of AD.</description><subject>Allergic diseases</subject><subject>Animals</subject><subject>atopic dermatitis</subject><subject>Biological and medical sciences</subject><subject>Dermatitis, Atopic - drug therapy</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dermatitis, Atopic - microbiology</subject><subject>Dermatology</subject><subject>Female</subject><subject>IgE</subject><subject>Immunoglobulin E - blood</subject><subject>Immunopathology</subject><subject>Interferon-gamma - blood</subject><subject>interferon-γ</subject><subject>interleukin-4</subject><subject>Interleukin-4 - blood</subject><subject>Liver Function Tests</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Models, Animal</subject><subject>NC/Nga mice</subject><subject>Phytotherapy - methods</subject><subject>Picryl Chloride</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Plants, Medicinal</subject><subject>Rumex</subject><subject>Rumex japonicus Houtt</subject><subject>Skin - drug effects</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Staphylococcal Infections - complications</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcus aureus - isolation & purification</subject><subject>Treatment Outcome</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkV1v2yAUhtG0aU27_YWJm-3OLhgM9sUutvQjrapUqrqPO0Tw8UpiG9fgLvn3w0vacsMR7_MiwYMQpiSlcZ2uU8pEnmSUsTQjRKREMsLS7Rs0ewneohkhRCakFOwIHXu_JoQykpP36IgKWWaSlzM0XnUPdmWDG3YY6hpM8NjV-G5sYYvXunedNaPHCzeGkGLX4fAAuIInaFzfQhcmWAfXWxNPh1YHG6xPGrsB7De2ww146zqP47icny7_aNxaAx_Qu1o3Hj4e9hP04-L8fr5Ibm4vr-bfbhLDCsGSihpWAaHCkAoKqbWgLCuqklWZZMD5KmY5Lw0nFDTPyrwq4osNLUtOpKyAnaAv-3v7wT2O4INqrTfQNLoDN3olilxImssIfjqA46qFSvWDbfWwU88fFYHPB0B7o5t60J2x_pWTBS8ynkXu6577axvYveZETeLUWk1-1ORHTeLUf3Fqq75fn01T7Cf7vvUBti99PWyUkEzm6tfyUt3d08XZ9U-ufrN_Rw6aZg</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>Lee, H-S.</creator><creator>Kim, S-K.</creator><creator>Han, J-B.</creator><creator>Choi, H-M.</creator><creator>Park, J-H.</creator><creator>Kim, E-C.</creator><creator>Choi, M-S.</creator><creator>An, H-J.</creator><creator>Um, J-Y.</creator><creator>Kim, H-M.</creator><creator>Min, B-I.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice</title><author>Lee, H-S. ; Kim, S-K. ; Han, J-B. ; Choi, H-M. ; Park, J-H. ; Kim, E-C. ; Choi, M-S. ; An, H-J. ; Um, J-Y. ; Kim, H-M. ; Min, B-I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3863-d1c3de016c0de87aa61328d93d273e44be01549c401ea4295d8007c1994077de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Allergic diseases</topic><topic>Animals</topic><topic>atopic dermatitis</topic><topic>Biological and medical sciences</topic><topic>Dermatitis, Atopic - drug therapy</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Dermatitis, Atopic - microbiology</topic><topic>Dermatology</topic><topic>Female</topic><topic>IgE</topic><topic>Immunoglobulin E - blood</topic><topic>Immunopathology</topic><topic>Interferon-gamma - blood</topic><topic>interferon-γ</topic><topic>interleukin-4</topic><topic>Interleukin-4 - blood</topic><topic>Liver Function Tests</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Models, Animal</topic><topic>NC/Nga mice</topic><topic>Phytotherapy - methods</topic><topic>Picryl Chloride</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Plants, Medicinal</topic><topic>Rumex</topic><topic>Rumex japonicus Houtt</topic><topic>Skin - drug effects</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>Staphylococcal Infections - complications</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcus aureus - isolation & purification</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, H-S.</creatorcontrib><creatorcontrib>Kim, S-K.</creatorcontrib><creatorcontrib>Han, J-B.</creatorcontrib><creatorcontrib>Choi, H-M.</creatorcontrib><creatorcontrib>Park, J-H.</creatorcontrib><creatorcontrib>Kim, E-C.</creatorcontrib><creatorcontrib>Choi, M-S.</creatorcontrib><creatorcontrib>An, H-J.</creatorcontrib><creatorcontrib>Um, J-Y.</creatorcontrib><creatorcontrib>Kim, H-M.</creatorcontrib><creatorcontrib>Min, B-I.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, H-S.</au><au>Kim, S-K.</au><au>Han, J-B.</au><au>Choi, H-M.</au><au>Park, J-H.</au><au>Kim, E-C.</au><au>Choi, M-S.</au><au>An, H-J.</au><au>Um, J-Y.</au><au>Kim, H-M.</au><au>Min, B-I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2006-07</date><risdate>2006</risdate><volume>155</volume><issue>1</issue><spage>33</spage><epage>38</epage><pages>33-38</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background Rumex japonicus Houtt. (RJH) is one of the herbs used in Eastern countries for the treatment of atopic dermatitis (AD). It has been shown to have an antioxidative effect in human skin disease.
Objectives To examine whether RJH extract (RJH‐E) suppresses the development of AD‐like skin lesions in NC/Nga mice, which are induced by the repeated application of picryl chloride (PC).
Methods The efficacy of RJH‐E in NC/Nga mice was assessed by measuring symptom severity, scratching behaviour, Staphylococcus aureus numbers on an ear, and serum levels of IgE, interleukin (IL)‐4 and interferon (IFN)‐γ.
Results Oral administration of RJH‐E to NC/Nga mice treated with PC inhibited the development of AD‐like skin lesions as exemplified by a significant decrease in total skin symptom severity scores, and a decrease in hypertrophy, hyperkeratosis and infiltration of inflammatory cells in the skin. The scratching behaviour and numbers of S. aureus, which are known to be exacerbated in AD, were also significantly reduced by RJH‐E. No significant change was observed in the serum levels of IFN‐γ, whereas IgE and IL‐4 levels were significantly reduced by RJH‐E.
Conclusions These results suggest that RJH‐E inhibits the development of AD‐like skin lesions in NC/Nga mice by suppressing the T‐helper 2 cell response. Our results indicate that RJH treatment could provide an effective alternative therapy for the management of AD.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16792749</pmid><doi>10.1111/j.1365-2133.2006.07303.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 2006-07, Vol.155 (1), p.33-38 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Allergic diseases Animals atopic dermatitis Biological and medical sciences Dermatitis, Atopic - drug therapy Dermatitis, Atopic - immunology Dermatitis, Atopic - microbiology Dermatology Female IgE Immunoglobulin E - blood Immunopathology Interferon-gamma - blood interferon-γ interleukin-4 Interleukin-4 - blood Liver Function Tests Medical sciences Mice Mice, Mutant Strains Models, Animal NC/Nga mice Phytotherapy - methods Picryl Chloride Plant Extracts - therapeutic use Plant Roots Plants, Medicinal Rumex Rumex japonicus Houtt Skin - drug effects Skin allergic diseases. Stinging insect allergies Staphylococcal Infections - complications Staphylococcal Infections - drug therapy Staphylococcus aureus - isolation & purification Treatment Outcome |
| title | Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice |
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