Induction of anti-proliferative mechanisms in hepatitis B virus producing cells

Hepatitis B virus (HBV) preferentially replicates in quiescent cells. It was analyzed whether HBV affects cell cycle control. The amount of EGF-receptor (EGFR) and the binding capacity for 125I-EGF was determined. Expression of mdm2 and p21 and relevance of p53 for it were analyzed by reporter gene...

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Veröffentlicht in:Journal of hepatology 2005-10, Vol.43 (4), p.696-703
Hauptverfasser: Friedrich, Beate, Wollersheim, Madlen, Brandenburg, Boerries, Foerste, Ramona, Will, Hans, Hildt, Eberhard
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Sprache:eng
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