Protective effects of a calcium channel blocker on apoptosis in thymus of neonatal STZ-diabetic rats

Streptozotocin (STZ) is known to induce insulin-dependent diabetes in experimental animals. In STZ-induced diabetes, atrophy of the thymus is caused by elevated intracellular calcium levels leading to apoptosis. Hyperglycemia is known to result in a decrease in numbers of T cells in the thymus and c...

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Veröffentlicht in:	Acta histochemica 2005-01, Vol.107 (3), p.207-214
Hauptverfasser:	Dagistanli, Fatma Kaya, Duman, Belgin Susleyici, Ozturk, Melek
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Apoptosis - drug effects Blood Glucose - analysis Calcium Channel Blockers - therapeutic use Cell Count Dexamethasone - pharmacology Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - pathology Disease Models, Animal DNA Fragmentation In Situ Nick-End Labeling Injections, Intraperitoneal Isradipine Isradipine - therapeutic use Neonatal STZ diabetic rats Rats Rats, Wistar Thymus Thymus Gland - drug effects Thymus Gland - pathology
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