A flow-injection biamperometric method for determination of pantoprazole in pharmaceutical tablets
A flow-injection biamperometric method for determination of pantoprazole (PTZ) in pharmaceutical tablets is reported for the first time. The reversible redox couples Fe3+/Fe2+, Fe(CN)6(3-)/Fe(CN)6(4-), Ce4+/Ce3+, VO3(-)NO2+, and I2/I- were tested as indicating redox systems for biamperometric determ...
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creator | CASTRO, Slzana L PESSOA NETO, Osmundo D SANTOS, Sergio R. B MEDEIROS, Everaldo P LIMA, Ricardo A. C MARTINS, Valdomiro L ARAUO, Mario C. U SANTOS, Josué C. C KORN, Mauro |
description | A flow-injection biamperometric method for determination of pantoprazole (PTZ) in pharmaceutical tablets is reported for the first time. The reversible redox couples Fe3+/Fe2+, Fe(CN)6(3-)/Fe(CN)6(4-), Ce4+/Ce3+, VO3(-)NO2+, and I2/I- were tested as indicating redox systems for biamperometric determination of PTZ in a flow-injection assembly with optimized flow parameters. The best results were obtained using V03(-)NO2+, which showed to be a selective and sensitive biamperometric indicating system for PTZ even in the presence of excipients and antioxidants that typically are found in drugs. The analytical graph was linear (r = 0.99945) in the range from 10 to 100 mg/L using 25 mmol/L VO3(-) as the reagent and water as the carrier stream and applying 100 mV between the 2 platinum wire electrodes. The limits of detection and quantitation were 200 and 667 microg/L, respectively, with a sensibility of calibration of 22.6 mV/mg/L. The proposed method was successfully applied to determine PTZ in commercial pharmaceutical tablets with a mean relative error of 1.60% (n = 5) and mean relative standard deviation of 3.10%. Recoveries close to 100% showed good agreement between the expected amount of PTZ in tablets (40 mg) and the results found by the application of the proposed method and demonstrated that the formulations used in the tablet compositions do not interfere in the PTZ analysis. The system had good stability, with a relative standard deviation of 3.80% for 9 sequential injections of a 60 mg/L PTZ solution. A sampling rate of about 100 samples/h was obtained. |
doi_str_mv | 10.1093/jaoac/88.4.1064 |
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B ; MEDEIROS, Everaldo P ; LIMA, Ricardo A. C ; MARTINS, Valdomiro L ; ARAUO, Mario C. U ; SANTOS, Josué C. C ; KORN, Mauro</creator><creatorcontrib>CASTRO, Slzana L ; PESSOA NETO, Osmundo D ; SANTOS, Sergio R. B ; MEDEIROS, Everaldo P ; LIMA, Ricardo A. C ; MARTINS, Valdomiro L ; ARAUO, Mario C. U ; SANTOS, Josué C. C ; KORN, Mauro</creatorcontrib><description>A flow-injection biamperometric method for determination of pantoprazole (PTZ) in pharmaceutical tablets is reported for the first time. The reversible redox couples Fe3+/Fe2+, Fe(CN)6(3-)/Fe(CN)6(4-), Ce4+/Ce3+, VO3(-)NO2+, and I2/I- were tested as indicating redox systems for biamperometric determination of PTZ in a flow-injection assembly with optimized flow parameters. The best results were obtained using V03(-)NO2+, which showed to be a selective and sensitive biamperometric indicating system for PTZ even in the presence of excipients and antioxidants that typically are found in drugs. The analytical graph was linear (r = 0.99945) in the range from 10 to 100 mg/L using 25 mmol/L VO3(-) as the reagent and water as the carrier stream and applying 100 mV between the 2 platinum wire electrodes. The limits of detection and quantitation were 200 and 667 microg/L, respectively, with a sensibility of calibration of 22.6 mV/mg/L. The proposed method was successfully applied to determine PTZ in commercial pharmaceutical tablets with a mean relative error of 1.60% (n = 5) and mean relative standard deviation of 3.10%. Recoveries close to 100% showed good agreement between the expected amount of PTZ in tablets (40 mg) and the results found by the application of the proposed method and demonstrated that the formulations used in the tablet compositions do not interfere in the PTZ analysis. The system had good stability, with a relative standard deviation of 3.80% for 9 sequential injections of a 60 mg/L PTZ solution. A sampling rate of about 100 samples/h was obtained.</description><identifier>ISSN: 1060-3271</identifier><identifier>EISSN: 1944-7922</identifier><identifier>DOI: 10.1093/jaoac/88.4.1064</identifier><identifier>PMID: 16152921</identifier><language>eng</language><publisher>Gaithersburg, MD: AOAC International</publisher><subject>2-Pyridinylmethylsulfinylbenzimidazoles ; Anti-Ulcer Agents - analysis ; Benzimidazoles - analysis ; Biological and medical sciences ; Calibration ; Chemistry Techniques, Analytical - methods ; Chemistry, Pharmaceutical - methods ; Conductometric analysis ; Drugs ; Electrochemistry - methods ; Electrodes ; Flow Injection Analysis - methods ; Food industries ; Fundamental and applied biological sciences. Psychology ; Methods ; Models, Chemical ; Omeprazole - analogs & derivatives ; Omeprazole - analysis ; Oxidation-Reduction ; Pantoprazole ; Product/Service Evaluations ; Protons ; Reproducibility of Results ; Sulfoxides - analysis ; Tablets ; Technology, Pharmaceutical - instrumentation ; Technology, Pharmaceutical - methods ; Testing</subject><ispartof>Journal of AOAC International, 2005-07, Vol.88 (4), p.1064-1068</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2005 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-3b3658248a3fa0595532e7e758c8f78848c42a22f4b309991892ea666ce218c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16996757$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16152921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CASTRO, Slzana L</creatorcontrib><creatorcontrib>PESSOA NETO, Osmundo D</creatorcontrib><creatorcontrib>SANTOS, Sergio R. B</creatorcontrib><creatorcontrib>MEDEIROS, Everaldo P</creatorcontrib><creatorcontrib>LIMA, Ricardo A. C</creatorcontrib><creatorcontrib>MARTINS, Valdomiro L</creatorcontrib><creatorcontrib>ARAUO, Mario C. U</creatorcontrib><creatorcontrib>SANTOS, Josué C. C</creatorcontrib><creatorcontrib>KORN, Mauro</creatorcontrib><title>A flow-injection biamperometric method for determination of pantoprazole in pharmaceutical tablets</title><title>Journal of AOAC International</title><addtitle>J AOAC Int</addtitle><description>A flow-injection biamperometric method for determination of pantoprazole (PTZ) in pharmaceutical tablets is reported for the first time. The reversible redox couples Fe3+/Fe2+, Fe(CN)6(3-)/Fe(CN)6(4-), Ce4+/Ce3+, VO3(-)NO2+, and I2/I- were tested as indicating redox systems for biamperometric determination of PTZ in a flow-injection assembly with optimized flow parameters. The best results were obtained using V03(-)NO2+, which showed to be a selective and sensitive biamperometric indicating system for PTZ even in the presence of excipients and antioxidants that typically are found in drugs. The analytical graph was linear (r = 0.99945) in the range from 10 to 100 mg/L using 25 mmol/L VO3(-) as the reagent and water as the carrier stream and applying 100 mV between the 2 platinum wire electrodes. The limits of detection and quantitation were 200 and 667 microg/L, respectively, with a sensibility of calibration of 22.6 mV/mg/L. The proposed method was successfully applied to determine PTZ in commercial pharmaceutical tablets with a mean relative error of 1.60% (n = 5) and mean relative standard deviation of 3.10%. Recoveries close to 100% showed good agreement between the expected amount of PTZ in tablets (40 mg) and the results found by the application of the proposed method and demonstrated that the formulations used in the tablet compositions do not interfere in the PTZ analysis. The system had good stability, with a relative standard deviation of 3.80% for 9 sequential injections of a 60 mg/L PTZ solution. A sampling rate of about 100 samples/h was obtained.</description><subject>2-Pyridinylmethylsulfinylbenzimidazoles</subject><subject>Anti-Ulcer Agents - analysis</subject><subject>Benzimidazoles - analysis</subject><subject>Biological and medical sciences</subject><subject>Calibration</subject><subject>Chemistry Techniques, Analytical - methods</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Conductometric analysis</subject><subject>Drugs</subject><subject>Electrochemistry - methods</subject><subject>Electrodes</subject><subject>Flow Injection Analysis - methods</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Methods</subject><subject>Models, Chemical</subject><subject>Omeprazole - analogs & derivatives</subject><subject>Omeprazole - analysis</subject><subject>Oxidation-Reduction</subject><subject>Pantoprazole</subject><subject>Product/Service Evaluations</subject><subject>Protons</subject><subject>Reproducibility of Results</subject><subject>Sulfoxides - analysis</subject><subject>Tablets</subject><subject>Technology, Pharmaceutical - instrumentation</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Testing</subject><issn>1060-3271</issn><issn>1944-7922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0cuLFDEQB-BGFHddPXuTBtFbz-TVeRyHxRcseNl7qM5U3AzdSZtkEP3rzewMqCA5VBK-KkJ-Xfeakg0lhm8PkMBttd6IdpbiSXdNjRCDMow9bXsiycCZolfdi1IOhAgqCXveXVFJR2YYve6mXe_n9GMI8YCuhhT7KcCyYk4L1hxc38pD2vc-5X6PFfMSIjy65PsVYk1rhl9pxj7Efn2AvIDDYw0O5r7CNGMtL7tnHuaCry71prv_-OH-9vNw9_XTl9vd3eAE53XgE5ejZkID90BGM46coUI1aqe90lpoJxgw5sXEiTGGasMQpJQOGdWO33Tvz2PXnL4fsVS7hOJwniFiOhYr9djmK93g2zP8BjPaEH2qGdwJ2x3VhMjRKNbU5j-qrT0uwaWIPrT7fxq25waXUykZvV1zWCD_tJTYU1j2MSyrtRX2FFbreHN58XFacP_HX9Jp4N0FQGkf6jNEF8pfzhipRsV_A492nPA</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>CASTRO, Slzana L</creator><creator>PESSOA NETO, Osmundo D</creator><creator>SANTOS, Sergio R. B</creator><creator>MEDEIROS, Everaldo P</creator><creator>LIMA, Ricardo A. C</creator><creator>MARTINS, Valdomiro L</creator><creator>ARAUO, Mario C. U</creator><creator>SANTOS, Josué C. C</creator><creator>KORN, Mauro</creator><general>AOAC International</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>A flow-injection biamperometric method for determination of pantoprazole in pharmaceutical tablets</title><author>CASTRO, Slzana L ; PESSOA NETO, Osmundo D ; SANTOS, Sergio R. B ; MEDEIROS, Everaldo P ; LIMA, Ricardo A. C ; MARTINS, Valdomiro L ; ARAUO, Mario C. U ; SANTOS, Josué C. C ; KORN, Mauro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-3b3658248a3fa0595532e7e758c8f78848c42a22f4b309991892ea666ce218c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>2-Pyridinylmethylsulfinylbenzimidazoles</topic><topic>Anti-Ulcer Agents - analysis</topic><topic>Benzimidazoles - analysis</topic><topic>Biological and medical sciences</topic><topic>Calibration</topic><topic>Chemistry Techniques, Analytical - methods</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Conductometric analysis</topic><topic>Drugs</topic><topic>Electrochemistry - methods</topic><topic>Electrodes</topic><topic>Flow Injection Analysis - methods</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Methods</topic><topic>Models, Chemical</topic><topic>Omeprazole - analogs & derivatives</topic><topic>Omeprazole - analysis</topic><topic>Oxidation-Reduction</topic><topic>Pantoprazole</topic><topic>Product/Service Evaluations</topic><topic>Protons</topic><topic>Reproducibility of Results</topic><topic>Sulfoxides - analysis</topic><topic>Tablets</topic><topic>Technology, Pharmaceutical - instrumentation</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Testing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CASTRO, Slzana L</creatorcontrib><creatorcontrib>PESSOA NETO, Osmundo D</creatorcontrib><creatorcontrib>SANTOS, Sergio R. B</creatorcontrib><creatorcontrib>MEDEIROS, Everaldo P</creatorcontrib><creatorcontrib>LIMA, Ricardo A. C</creatorcontrib><creatorcontrib>MARTINS, Valdomiro L</creatorcontrib><creatorcontrib>ARAUO, Mario C. U</creatorcontrib><creatorcontrib>SANTOS, Josué C. C</creatorcontrib><creatorcontrib>KORN, Mauro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of AOAC International</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CASTRO, Slzana L</au><au>PESSOA NETO, Osmundo D</au><au>SANTOS, Sergio R. B</au><au>MEDEIROS, Everaldo P</au><au>LIMA, Ricardo A. C</au><au>MARTINS, Valdomiro L</au><au>ARAUO, Mario C. U</au><au>SANTOS, Josué C. C</au><au>KORN, Mauro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A flow-injection biamperometric method for determination of pantoprazole in pharmaceutical tablets</atitle><jtitle>Journal of AOAC International</jtitle><addtitle>J AOAC Int</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>88</volume><issue>4</issue><spage>1064</spage><epage>1068</epage><pages>1064-1068</pages><issn>1060-3271</issn><eissn>1944-7922</eissn><abstract>A flow-injection biamperometric method for determination of pantoprazole (PTZ) in pharmaceutical tablets is reported for the first time. The reversible redox couples Fe3+/Fe2+, Fe(CN)6(3-)/Fe(CN)6(4-), Ce4+/Ce3+, VO3(-)NO2+, and I2/I- were tested as indicating redox systems for biamperometric determination of PTZ in a flow-injection assembly with optimized flow parameters. The best results were obtained using V03(-)NO2+, which showed to be a selective and sensitive biamperometric indicating system for PTZ even in the presence of excipients and antioxidants that typically are found in drugs. The analytical graph was linear (r = 0.99945) in the range from 10 to 100 mg/L using 25 mmol/L VO3(-) as the reagent and water as the carrier stream and applying 100 mV between the 2 platinum wire electrodes. The limits of detection and quantitation were 200 and 667 microg/L, respectively, with a sensibility of calibration of 22.6 mV/mg/L. The proposed method was successfully applied to determine PTZ in commercial pharmaceutical tablets with a mean relative error of 1.60% (n = 5) and mean relative standard deviation of 3.10%. Recoveries close to 100% showed good agreement between the expected amount of PTZ in tablets (40 mg) and the results found by the application of the proposed method and demonstrated that the formulations used in the tablet compositions do not interfere in the PTZ analysis. The system had good stability, with a relative standard deviation of 3.80% for 9 sequential injections of a 60 mg/L PTZ solution. A sampling rate of about 100 samples/h was obtained.</abstract><cop>Gaithersburg, MD</cop><pub>AOAC International</pub><pmid>16152921</pmid><doi>10.1093/jaoac/88.4.1064</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
subjects | 2-Pyridinylmethylsulfinylbenzimidazoles Anti-Ulcer Agents - analysis Benzimidazoles - analysis Biological and medical sciences Calibration Chemistry Techniques, Analytical - methods Chemistry, Pharmaceutical - methods Conductometric analysis Drugs Electrochemistry - methods Electrodes Flow Injection Analysis - methods Food industries Fundamental and applied biological sciences. Psychology Methods Models, Chemical Omeprazole - analogs & derivatives Omeprazole - analysis Oxidation-Reduction Pantoprazole Product/Service Evaluations Protons Reproducibility of Results Sulfoxides - analysis Tablets Technology, Pharmaceutical - instrumentation Technology, Pharmaceutical - methods Testing |
title | A flow-injection biamperometric method for determination of pantoprazole in pharmaceutical tablets |
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