Repetitive DNA polymorphisms in following chimerism after allogeneic bone marrow transplantation
: Information about the chimeric status of patients is of great importance in comparison of different conditioning and prophylactic regimens as well as for the post‐bone marrow transplantation (BMT) therapies. In some cases, mixed chimerism (MC) can also be predictive of relapse. Analysis of the sh...
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| Veröffentlicht in: | Clinical transplantation 2005-10, Vol.19 (5), p.586-590 |
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| creator | Grubic, Zorana Stingl, Katarina Jelicic, Esma Cecuk Zunec, Renata Kastelan, Andrija Seiwerth, Ranka Serventi Bogdanic, Vinko Labar, Boris Brkljacic, Vesna Kerhin |
| description | : Information about the chimeric status of patients is of great importance in comparison of different conditioning and prophylactic regimens as well as for the post‐bone marrow transplantation (BMT) therapies. In some cases, mixed chimerism (MC) can also be predictive of relapse. Analysis of the short tandem repeats (STR) loci by polymerase chain reaction (PCR) is a choice method for this purpose. In this study, we monitored 15 patients after BMT. Twelve of them underwent classical‐conditioning regimen while the remaining three patients were subjected to non‐myeloablative conditioning (minitransplantation). Evaluation of chimerism was performed using five STR and one variable number of tandem repeats (VNTR) locus. Four additional loci were PCR‐amplified in cases of minitransplantation. Samples were analyzed by electrophoresis in an ALFexpress sequencer. MC was detected in seven cases of which it was predictive of relapse for two patients, who suffered from acute lymphocytic leukemia (ALL). The PCR‐STR method proved to be a fast and relatively simple method, while the tested STR loci showed a high level of informativeness. |
| doi_str_mv | 10.1111/j.1399-0012.2004.00313.x |
| format | Article |
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In some cases, mixed chimerism (MC) can also be predictive of relapse. Analysis of the short tandem repeats (STR) loci by polymerase chain reaction (PCR) is a choice method for this purpose. In this study, we monitored 15 patients after BMT. Twelve of them underwent classical‐conditioning regimen while the remaining three patients were subjected to non‐myeloablative conditioning (minitransplantation). Evaluation of chimerism was performed using five STR and one variable number of tandem repeats (VNTR) locus. Four additional loci were PCR‐amplified in cases of minitransplantation. Samples were analyzed by electrophoresis in an ALFexpress sequencer. MC was detected in seven cases of which it was predictive of relapse for two patients, who suffered from acute lymphocytic leukemia (ALL). The PCR‐STR method proved to be a fast and relatively simple method, while the tested STR loci showed a high level of informativeness.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/j.1399-0012.2004.00313.x</identifier><identifier>PMID: 16146548</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adolescent ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone Marrow Transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Child ; Child, Preschool ; Chimerism ; DNA - genetics ; Electrophoresis ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genetic Markers ; Graft Rejection - diagnosis ; Graft Rejection - genetics ; Humans ; Male ; Medical sciences ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery ; Prognosis ; Recurrence ; Risk Factors ; short tandem repeats ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tandem Repeat Sequences - genetics ; Tissue, organ and graft immunology ; Transfusions. Complications. Transfusion reactions. 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In some cases, mixed chimerism (MC) can also be predictive of relapse. Analysis of the short tandem repeats (STR) loci by polymerase chain reaction (PCR) is a choice method for this purpose. In this study, we monitored 15 patients after BMT. Twelve of them underwent classical‐conditioning regimen while the remaining three patients were subjected to non‐myeloablative conditioning (minitransplantation). Evaluation of chimerism was performed using five STR and one variable number of tandem repeats (VNTR) locus. Four additional loci were PCR‐amplified in cases of minitransplantation. Samples were analyzed by electrophoresis in an ALFexpress sequencer. MC was detected in seven cases of which it was predictive of relapse for two patients, who suffered from acute lymphocytic leukemia (ALL). The PCR‐STR method proved to be a fast and relatively simple method, while the tested STR loci showed a high level of informativeness.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chimerism</subject><subject>DNA - genetics</subject><subject>Electrophoresis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genetic Markers</subject><subject>Graft Rejection - diagnosis</subject><subject>Graft Rejection - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>short tandem repeats</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tandem Repeat Sequences - genetics</subject><subject>Tissue, organ and graft immunology</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Transplantation, Homologous</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhLyBf4JbUiWM7kbhUW1oQ1SL6IbgZ2xm3XpI42Fl299_X2121V3wZa-Z57dGDEC5IXqRzsswL2jQZIUWZl4RUOSG0oPnmBZo9DV6iGWlIme6cHqE3MS5TlxecvUZHqVacVfUM_b6CESY3uX-AzxanePTdtvdhvHexj9gN2Pqu82s33GFz73oIqY-VnSBglQZ3MIAzWPsBcK9C8Gs8BTXEsVPDpCbnh7folVVdhHeHeoxuzz_fzL9kl98vvs5PLzNT0YpmtmwqQVpjddkCYxURpiCGMd2WgltNaiuIVbbmraagtRDCQKOVabmqOBGcHqOP-3fH4P-uIE6yd9FAlxYBv4qS14wz8QjWe9AEH2MAK8fg0u5bWRC5syuXcidR7iTKnV35aFduUvT94Y-V7qF9Dh50JuDDAVDRqM4mFcbFZ04QQXhNE_dpz61dB9v_XkDOb67SJcWzfdzFCTZPcRX-SC6oYPLn4kL-uj5fMF5_kz_oA-cQprM</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Grubic, Zorana</creator><creator>Stingl, Katarina</creator><creator>Jelicic, Esma Cecuk</creator><creator>Zunec, Renata</creator><creator>Kastelan, Andrija</creator><creator>Seiwerth, Ranka Serventi</creator><creator>Bogdanic, Vinko</creator><creator>Labar, Boris</creator><creator>Brkljacic, Vesna Kerhin</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Repetitive DNA polymorphisms in following chimerism after allogeneic bone marrow transplantation</title><author>Grubic, Zorana ; Stingl, Katarina ; Jelicic, Esma Cecuk ; Zunec, Renata ; Kastelan, Andrija ; Seiwerth, Ranka Serventi ; Bogdanic, Vinko ; Labar, Boris ; Brkljacic, Vesna Kerhin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4343-f29470dcfb2de55407c10c55bd276fb08f70faf86db3ebb777ce9bacd6a460763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chimerism</topic><topic>DNA - genetics</topic><topic>Electrophoresis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genetic Markers</topic><topic>Graft Rejection - diagnosis</topic><topic>Graft Rejection - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>short tandem repeats</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tandem Repeat Sequences - genetics</topic><topic>Tissue, organ and graft immunology</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grubic, Zorana</creatorcontrib><creatorcontrib>Stingl, Katarina</creatorcontrib><creatorcontrib>Jelicic, Esma Cecuk</creatorcontrib><creatorcontrib>Zunec, Renata</creatorcontrib><creatorcontrib>Kastelan, Andrija</creatorcontrib><creatorcontrib>Seiwerth, Ranka Serventi</creatorcontrib><creatorcontrib>Bogdanic, Vinko</creatorcontrib><creatorcontrib>Labar, Boris</creatorcontrib><creatorcontrib>Brkljacic, Vesna Kerhin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grubic, Zorana</au><au>Stingl, Katarina</au><au>Jelicic, Esma Cecuk</au><au>Zunec, Renata</au><au>Kastelan, Andrija</au><au>Seiwerth, Ranka Serventi</au><au>Bogdanic, Vinko</au><au>Labar, Boris</au><au>Brkljacic, Vesna Kerhin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repetitive DNA polymorphisms in following chimerism after allogeneic bone marrow transplantation</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2005-10</date><risdate>2005</risdate><volume>19</volume><issue>5</issue><spage>586</spage><epage>590</epage><pages>586-590</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>: Information about the chimeric status of patients is of great importance in comparison of different conditioning and prophylactic regimens as well as for the post‐bone marrow transplantation (BMT) therapies. In some cases, mixed chimerism (MC) can also be predictive of relapse. Analysis of the short tandem repeats (STR) loci by polymerase chain reaction (PCR) is a choice method for this purpose. In this study, we monitored 15 patients after BMT. Twelve of them underwent classical‐conditioning regimen while the remaining three patients were subjected to non‐myeloablative conditioning (minitransplantation). Evaluation of chimerism was performed using five STR and one variable number of tandem repeats (VNTR) locus. Four additional loci were PCR‐amplified in cases of minitransplantation. Samples were analyzed by electrophoresis in an ALFexpress sequencer. MC was detected in seven cases of which it was predictive of relapse for two patients, who suffered from acute lymphocytic leukemia (ALL). The PCR‐STR method proved to be a fast and relatively simple method, while the tested STR loci showed a high level of informativeness.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>16146548</pmid><doi>10.1111/j.1399-0012.2004.00313.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical transplantation, 2005-10, Vol.19 (5), p.586-590 |
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| subjects | Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Child Child, Preschool Chimerism DNA - genetics Electrophoresis Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic Markers Graft Rejection - diagnosis Graft Rejection - genetics Humans Male Medical sciences Middle Aged Polymerase Chain Reaction Polymorphism, Genetic Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery Prognosis Recurrence Risk Factors short tandem repeats Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tandem Repeat Sequences - genetics Tissue, organ and graft immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation, Homologous |
| title | Repetitive DNA polymorphisms in following chimerism after allogeneic bone marrow transplantation |
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