Neural tube derived signals and Fgf8 act antagonistically to specify eye versus mandibular arch muscles

Recent knockout experiments in the mouse generated amazing craniofacial skeletal muscle phenotypes. Yet none of the genes could be placed into a molecular network, because the programme to control the development of muscles in the head is not known. Here we show that antagonistic signals from the ne...

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Veröffentlicht in:	Development (Cambridge) 2006-07, Vol.133 (14), p.2731-2745
Hauptverfasser:	von Scheven, Gudrun, Alvares, Lúcia E, Mootoosamy, Roy C, Dietrich, Susanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Branchial Region - anatomy & histology Branchial Region - embryology Chick Embryo Eye - anatomy & histology Eye - embryology Fibroblast Growth Factor 8 - genetics Fibroblast Growth Factor 8 - metabolism Gene Expression Regulation, Developmental Head - anatomy & histology Head - embryology Humans Mesoderm - cytology Mesoderm - physiology Mice Models, Anatomic Morphogenesis Muscle Development - physiology Muscle, Skeletal - anatomy & histology Muscle, Skeletal - embryology Muscle, Skeletal - metabolism Neural Crest - cytology Neural Crest - physiology Oculomotor Muscles - embryology Oculomotor Muscles - innervation Phenotype Quail - anatomy & histology Quail - embryology Signal Transduction - physiology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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