Neural tube derived signals and Fgf8 act antagonistically to specify eye versus mandibular arch muscles
Recent knockout experiments in the mouse generated amazing craniofacial skeletal muscle phenotypes. Yet none of the genes could be placed into a molecular network, because the programme to control the development of muscles in the head is not known. Here we show that antagonistic signals from the ne...
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| Veröffentlicht in: | Development (Cambridge) 2006-07, Vol.133 (14), p.2731-2745 |
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| creator | von Scheven, Gudrun Alvares, Lúcia E Mootoosamy, Roy C Dietrich, Susanne |
| description | Recent knockout experiments in the mouse generated amazing craniofacial skeletal muscle phenotypes. Yet none of the genes could be placed into a molecular network, because the programme to control the development of muscles in the head is not known. Here we show that antagonistic signals from the neural tube and the branchial arches specify extraocular versus branchiomeric muscles. Moreover, we identified Fgf8 as the branchial arch derived signal. However, this molecule has an additional function in supporting the proliferative state of myoblasts, suppressing their differentiation, while a further branchial arch derived signal, namely Bmp7, is an overall negative regulator of head myogenesis. |
| doi_str_mv | 10.1242/dev.02426 |
| format | Article |
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Alvares, Lúcia E ; Mootoosamy, Roy C ; Dietrich, Susanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-2a4f2a800077d5577a41ba2db518cd767ecddf3620c71a14da53fcc4ce78ddd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Bone Morphogenetic Protein 7</topic><topic>Bone Morphogenetic Proteins - genetics</topic><topic>Bone Morphogenetic Proteins - metabolism</topic><topic>Branchial Region - anatomy & histology</topic><topic>Branchial Region - embryology</topic><topic>Chick Embryo</topic><topic>Eye - anatomy & histology</topic><topic>Eye - embryology</topic><topic>Fibroblast Growth Factor 8 - genetics</topic><topic>Fibroblast Growth Factor 8 - metabolism</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Head - anatomy & histology</topic><topic>Head - embryology</topic><topic>Humans</topic><topic>Mesoderm - cytology</topic><topic>Mesoderm - physiology</topic><topic>Mice</topic><topic>Models, Anatomic</topic><topic>Morphogenesis</topic><topic>Muscle Development - physiology</topic><topic>Muscle, Skeletal - anatomy & histology</topic><topic>Muscle, Skeletal - embryology</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Neural Crest - cytology</topic><topic>Neural Crest - physiology</topic><topic>Oculomotor Muscles - embryology</topic><topic>Oculomotor Muscles - innervation</topic><topic>Phenotype</topic><topic>Quail - anatomy & histology</topic><topic>Quail - embryology</topic><topic>Signal Transduction - physiology</topic><topic>Transforming Growth Factor beta - genetics</topic><topic>Transforming Growth Factor beta - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>von Scheven, Gudrun</creatorcontrib><creatorcontrib>Alvares, Lúcia E</creatorcontrib><creatorcontrib>Mootoosamy, Roy C</creatorcontrib><creatorcontrib>Dietrich, Susanne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>von Scheven, Gudrun</au><au>Alvares, Lúcia E</au><au>Mootoosamy, Roy C</au><au>Dietrich, Susanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural tube derived signals and Fgf8 act antagonistically to specify eye versus mandibular arch muscles</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2006-07-15</date><risdate>2006</risdate><volume>133</volume><issue>14</issue><spage>2731</spage><epage>2745</epage><pages>2731-2745</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>Recent knockout experiments in the mouse generated amazing craniofacial skeletal muscle phenotypes. Yet none of the genes could be placed into a molecular network, because the programme to control the development of muscles in the head is not known. Here we show that antagonistic signals from the neural tube and the branchial arches specify extraocular versus branchiomeric muscles. Moreover, we identified Fgf8 as the branchial arch derived signal. However, this molecule has an additional function in supporting the proliferative state of myoblasts, suppressing their differentiation, while a further branchial arch derived signal, namely Bmp7, is an overall negative regulator of head myogenesis.</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>16775000</pmid><doi>10.1242/dev.02426</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 2006-07, Vol.133 (14), p.2731-2745 |
| issn | 0950-1991 1477-9129 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Branchial Region - anatomy & histology Branchial Region - embryology Chick Embryo Eye - anatomy & histology Eye - embryology Fibroblast Growth Factor 8 - genetics Fibroblast Growth Factor 8 - metabolism Gene Expression Regulation, Developmental Head - anatomy & histology Head - embryology Humans Mesoderm - cytology Mesoderm - physiology Mice Models, Anatomic Morphogenesis Muscle Development - physiology Muscle, Skeletal - anatomy & histology Muscle, Skeletal - embryology Muscle, Skeletal - metabolism Neural Crest - cytology Neural Crest - physiology Oculomotor Muscles - embryology Oculomotor Muscles - innervation Phenotype Quail - anatomy & histology Quail - embryology Signal Transduction - physiology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism |
| title | Neural tube derived signals and Fgf8 act antagonistically to specify eye versus mandibular arch muscles |
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