Characterization of matrix metalloproteinases in denervated muscle

In a nerve crush model of denervation, we examined muscle matrix metalloproteinase (MMP) expression, localization and activity. In normal muscle, MMP mRNA levels were low, and immunohistochemically MMPs were distributed around the muscle fibre with MMPs‐3, ‐7 and ‐9 also staining at the neuromuscula...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2005-10, Vol.31 (5), p.545-555
Hauptverfasser:	Demestre, M., Orth, M., Wells, G. M., Gearing, A. J., Hughes, R. A. C., Gregson, N. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	72 kDa gelatinase Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Immunohistochemistry macrophage metalloelastase Male matrix metalloproteinases Matrix Metalloproteinases - biosynthesis Medical sciences MT1-MMP Muscle Denervation Muscle, Skeletal - enzymology Muscle, Skeletal - innervation Muscle, Skeletal - pathology Nerve Crush nerve regeneration Nerve Regeneration - physiology Neurology neuropathy Rats Rats, Inbred Lew Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Sciatic Nerve - injuries Tumors of the nervous system. Phacomatoses
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