Selective Losses of Brainstem Catecholamine Neurons After Hypoxia-Ischemia in the Immature Rat Pup
Hypoxic-ischemic (HI) injury in the preterm neonate incurs numerous functional deficits, however little is known about the neurochemically-defined brain nuclei that may underpin them. Key candidates are the brainstem catecholamine neurons. Using an immature animal model, the postnatal day (P)-3 (P3)...
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| Veröffentlicht in: | Pediatric research 2008-04, Vol.63 (4), p.364-369 |
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| creator | Buller, Kathryn M Wixey, Julie A Pathipati, Praneeti Carty, Michelle Colditz, Paul B Williams, Christopher E Scheepens, Arjan |
| description | Hypoxic-ischemic (HI) injury in the preterm neonate incurs numerous functional deficits, however little is known about the neurochemically-defined brain nuclei that may underpin them. Key candidates are the brainstem catecholamine neurons. Using an immature animal model, the postnatal day (P)-3 (P3) rat pup, we investigated the effects of HI on brainstem catecholamine neurons in the locus coeruleus, nucleus tractus solitarius (NTS), and ventrolateral medulla (VLM). On P21, we found that prior P3 HI significantly reduced numbers of catecholaminergic neurons in the locus coeruleus, NTS, and VLM. Only locus coeruleus A6, NTS A2, and VLM A1 noradrenergic neurons, but not NTS C2 and VLM C1 adrenergic neurons, were lost. There was also an associated reduction in dopamine-beta-hydroxylase-positive immunolabeling in the forebrain. These findings suggest neonatal HI can affect specific neurochemically-defined neuronal populations in the brainstem and that noradrenergic neurons are particularly vulnerable to HI injury. |
| doi_str_mv | 10.1203/PDR.0b013e3181659774 |
| format | Article |
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Key candidates are the brainstem catecholamine neurons. Using an immature animal model, the postnatal day (P)-3 (P3) rat pup, we investigated the effects of HI on brainstem catecholamine neurons in the locus coeruleus, nucleus tractus solitarius (NTS), and ventrolateral medulla (VLM). On P21, we found that prior P3 HI significantly reduced numbers of catecholaminergic neurons in the locus coeruleus, NTS, and VLM. Only locus coeruleus A6, NTS A2, and VLM A1 noradrenergic neurons, but not NTS C2 and VLM C1 adrenergic neurons, were lost. There was also an associated reduction in dopamine-beta-hydroxylase-positive immunolabeling in the forebrain. 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These findings suggest neonatal HI can affect specific neurochemically-defined neuronal populations in the brainstem and that noradrenergic neurons are particularly vulnerable to HI injury.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>basic-science-investigation</subject><subject>Biological and medical sciences</subject><subject>Brain Stem - metabolism</subject><subject>Brain Stem - pathology</subject><subject>Catecholamines - metabolism</subject><subject>Cell Count</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>General aspects</subject><subject>Hypoxia-Ischemia, Brain - metabolism</subject><subject>Hypoxia-Ischemia, Brain - pathology</subject><subject>Locus Coeruleus - metabolism</subject><subject>Locus Coeruleus - pathology</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myelin Sheath - metabolism</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Solitary Nucleus - metabolism</subject><subject>Solitary Nucleus - pathology</subject><subject>Ventromedial Hypothalamic Nucleus - metabolism</subject><subject>Ventromedial Hypothalamic Nucleus - pathology</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vEzEQhi0EomnhHyDkC9y2jL-9xxIojRRBVeC88jpj4mo_gu1F9N9jlAgkDhxGc5jnHc08hLxgcMk4iDe37-4uoQcmUDDLtGqNkY_IiikBDUhpHpMVgGCNaFt7Rs5zvgdgUln5lJwxK5Q2Elak_4wD-hJ_IN3OOWOmc6Bvk4tTLjjStSvo9_Pgxjgh_YhLmqdMr0LBRG8eDvPP6JpN9nsco6NxomWPdDOOriwJ6Z0r9HY5PCNPghsyPj_1C_L1-v2X9U2z_fRhs77aNl5yU5q-Vwy1Bt0qzkyLkoFxZmdrGceDAPQB7W6HTsoegwoAQXLXB6-t99yLC_L6uPeQ5u8L5tKNMXscBjfhvOROW6WFaXkF5RH0qb6cMHSHFEeXHjoG3W-3XXXb_eu2xl6e9i_9iLu_oZPMCrw6AS57N4TkJh_zH44DZ9JqWzl15HIdTd8wdffzkqbq5v8H_AI1_ZQB</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Buller, Kathryn M</creator><creator>Wixey, Julie A</creator><creator>Pathipati, Praneeti</creator><creator>Carty, Michelle</creator><creator>Colditz, Paul B</creator><creator>Williams, Christopher E</creator><creator>Scheepens, Arjan</creator><general>Nature Publishing Group US</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Selective Losses of Brainstem Catecholamine Neurons After Hypoxia-Ischemia in the Immature Rat Pup</title><author>Buller, Kathryn M ; Wixey, Julie A ; Pathipati, Praneeti ; Carty, Michelle ; Colditz, Paul B ; Williams, Christopher E ; Scheepens, Arjan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-bb51e6606952179e4107a7d8a7d7a2f30ecfe8ddea44bef5f00f42abfc68cc2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>basic-science-investigation</topic><topic>Biological and medical sciences</topic><topic>Brain Stem - metabolism</topic><topic>Brain Stem - pathology</topic><topic>Catecholamines - metabolism</topic><topic>Cell Count</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>General aspects</topic><topic>Hypoxia-Ischemia, Brain - metabolism</topic><topic>Hypoxia-Ischemia, Brain - pathology</topic><topic>Locus Coeruleus - metabolism</topic><topic>Locus Coeruleus - pathology</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myelin Sheath - metabolism</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Solitary Nucleus - metabolism</topic><topic>Solitary Nucleus - pathology</topic><topic>Ventromedial Hypothalamic Nucleus - metabolism</topic><topic>Ventromedial Hypothalamic Nucleus - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buller, Kathryn M</creatorcontrib><creatorcontrib>Wixey, Julie A</creatorcontrib><creatorcontrib>Pathipati, Praneeti</creatorcontrib><creatorcontrib>Carty, Michelle</creatorcontrib><creatorcontrib>Colditz, Paul B</creatorcontrib><creatorcontrib>Williams, Christopher E</creatorcontrib><creatorcontrib>Scheepens, Arjan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buller, Kathryn M</au><au>Wixey, Julie A</au><au>Pathipati, Praneeti</au><au>Carty, Michelle</au><au>Colditz, Paul B</au><au>Williams, Christopher E</au><au>Scheepens, Arjan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective Losses of Brainstem Catecholamine Neurons After Hypoxia-Ischemia in the Immature Rat Pup</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>63</volume><issue>4</issue><spage>364</spage><epage>369</epage><pages>364-369</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>Hypoxic-ischemic (HI) injury in the preterm neonate incurs numerous functional deficits, however little is known about the neurochemically-defined brain nuclei that may underpin them. 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| subjects | Animals Animals, Newborn basic-science-investigation Biological and medical sciences Brain Stem - metabolism Brain Stem - pathology Catecholamines - metabolism Cell Count Disease Models, Animal Female General aspects Hypoxia-Ischemia, Brain - metabolism Hypoxia-Ischemia, Brain - pathology Locus Coeruleus - metabolism Locus Coeruleus - pathology Medical sciences Medicine Medicine & Public Health Myelin Sheath - metabolism Neurons - metabolism Neurons - pathology Pediatric Surgery Pediatrics Rats Rats, Wistar Solitary Nucleus - metabolism Solitary Nucleus - pathology Ventromedial Hypothalamic Nucleus - metabolism Ventromedial Hypothalamic Nucleus - pathology |
| title | Selective Losses of Brainstem Catecholamine Neurons After Hypoxia-Ischemia in the Immature Rat Pup |
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