The Management and Outcome of Patients with Germ-cell Tumours Treated in the Edinburgh Cancer Centre Between 1988 and 2002
The aim of this retrospective analysis was to review the outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre over the past 15 years, and to see whether there had been any changes over three 5-year cohorts. Patients referred with gonadal and extra-gonadal primary germ-ce...
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| Veröffentlicht in: | Clinical oncology (Royal College of Radiologists (Great Britain)) 2005-09, Vol.17 (6), p.435-440 |
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| container_title | Clinical oncology (Royal College of Radiologists (Great Britain)) |
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| creator | Howard, G.C.W. Conkey, D.S. Peoples, S. McLaren, D.B. Hargreave, T.B. Tulloch, D.N. Walker, W. Kerr, G.R. |
| description | The aim of this retrospective analysis was to review the outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre over the past 15 years, and to see whether there had been any changes over three 5-year cohorts.
Patients referred with gonadal and extra-gonadal primary germ-cell tumours, between 1988 and 2002, were identified from the departmental database, and survival by stage and prognostic group was analysed.
The proportion of patients with stage I seminoma has significantly increased. The good prognosis of patients with early stage disease is confirmed, with the outcome for some groups of patients being better than expected. There is a non-significant trend to improved results over the three 5-year cohorts. The outcome for patients with stage IV seminoma is worse than would be expected, but numbers are small. The poor prognosis of patients with non-seminomatous germ-cell tumours who fall into the International Germ Cell Consensus Classification (IGCCC) poor-prognostic group is confirmed. Failure of patients with metastatic non-seminomatous germ-cell tumours to achieve a complete response to initial therapy is shown to be a poor prognostic indicator. |
| doi_str_mv | 10.1016/j.clon.2005.03.011 |
| format | Article |
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Patients referred with gonadal and extra-gonadal primary germ-cell tumours, between 1988 and 2002, were identified from the departmental database, and survival by stage and prognostic group was analysed.
The proportion of patients with stage I seminoma has significantly increased. The good prognosis of patients with early stage disease is confirmed, with the outcome for some groups of patients being better than expected. There is a non-significant trend to improved results over the three 5-year cohorts. The outcome for patients with stage IV seminoma is worse than would be expected, but numbers are small. The poor prognosis of patients with non-seminomatous germ-cell tumours who fall into the International Germ Cell Consensus Classification (IGCCC) poor-prognostic group is confirmed. Failure of patients with metastatic non-seminomatous germ-cell tumours to achieve a complete response to initial therapy is shown to be a poor prognostic indicator.</description><identifier>ISSN: 0936-6555</identifier><identifier>EISSN: 1433-2981</identifier><identifier>DOI: 10.1016/j.clon.2005.03.011</identifier><identifier>PMID: 16149287</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Combined Modality Therapy ; Disease-Free Survival ; Germ-cell tumours ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Neoplasms, Germ Cell and Embryonal - mortality ; Neoplasms, Germ Cell and Embryonal - pathology ; Neoplasms, Germ Cell and Embryonal - therapy ; prognostic group ; Retrospective Studies ; Risk Factors ; Survival Rate ; testicular cancer ; Testicular Neoplasms - mortality ; Testicular Neoplasms - pathology ; Testicular Neoplasms - therapy ; Treatment Outcome</subject><ispartof>Clinical oncology (Royal College of Radiologists (Great Britain)), 2005-09, Vol.17 (6), p.435-440</ispartof><rights>2005 The Royal College of Radiologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-f9d95ce0145a73fbaaf4e0d26753df050ab3c8757aa8664599578b3e84bdde583</citedby><cites>FETCH-LOGICAL-c354t-f9d95ce0145a73fbaaf4e0d26753df050ab3c8757aa8664599578b3e84bdde583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S093665550500141X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16149287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Howard, G.C.W.</creatorcontrib><creatorcontrib>Conkey, D.S.</creatorcontrib><creatorcontrib>Peoples, S.</creatorcontrib><creatorcontrib>McLaren, D.B.</creatorcontrib><creatorcontrib>Hargreave, T.B.</creatorcontrib><creatorcontrib>Tulloch, D.N.</creatorcontrib><creatorcontrib>Walker, W.</creatorcontrib><creatorcontrib>Kerr, G.R.</creatorcontrib><title>The Management and Outcome of Patients with Germ-cell Tumours Treated in the Edinburgh Cancer Centre Between 1988 and 2002</title><title>Clinical oncology (Royal College of Radiologists (Great Britain))</title><addtitle>Clin Oncol (R Coll Radiol)</addtitle><description>The aim of this retrospective analysis was to review the outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre over the past 15 years, and to see whether there had been any changes over three 5-year cohorts.
Patients referred with gonadal and extra-gonadal primary germ-cell tumours, between 1988 and 2002, were identified from the departmental database, and survival by stage and prognostic group was analysed.
The proportion of patients with stage I seminoma has significantly increased. The good prognosis of patients with early stage disease is confirmed, with the outcome for some groups of patients being better than expected. There is a non-significant trend to improved results over the three 5-year cohorts. The outcome for patients with stage IV seminoma is worse than would be expected, but numbers are small. The poor prognosis of patients with non-seminomatous germ-cell tumours who fall into the International Germ Cell Consensus Classification (IGCCC) poor-prognostic group is confirmed. Failure of patients with metastatic non-seminomatous germ-cell tumours to achieve a complete response to initial therapy is shown to be a poor prognostic indicator.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Combined Modality Therapy</subject><subject>Disease-Free Survival</subject><subject>Germ-cell tumours</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Germ Cell and Embryonal - mortality</subject><subject>Neoplasms, Germ Cell and Embryonal - pathology</subject><subject>Neoplasms, Germ Cell and Embryonal - therapy</subject><subject>prognostic group</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><subject>testicular cancer</subject><subject>Testicular Neoplasms - mortality</subject><subject>Testicular Neoplasms - pathology</subject><subject>Testicular Neoplasms - therapy</subject><subject>Treatment Outcome</subject><issn>0936-6555</issn><issn>1433-2981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAQha2qqCy0f6CHyqfeEuw4dmypF1hRQALBYTlbjj1hvdo4YDtF5dfX212JG6eRRu-9mfch9J2SmhIqzja13U6hbgjhNWE1ofQTWtCWsapRkn5GC6KYqATn_BidpLQhhDRSqi_omAraqkZ2C_S2WgO-M8E8wQghYxMcvp-znUbA04AfTPZlnfCrz2t8BXGsLGy3eDWP0xwTXkUwGRz2AecSdOl86Of4tMZLEyxEvCzmCPgC8itAwFRJ-f9E-bn5io4Gs03w7TBP0ePvy9Xyurq9v7pZnt9WlvE2V4NyilsgtOWmY0NvzNACcY3oOHMD4cT0zMqOd8ZIIVquFO9kz0C2vXPAJTtFP_e5z3F6mSFlPfq0a2ECTHPSQnLBRNMVYbMX2jilFGHQz9GPJv7VlOgdcb3RO-J6R1wTpgvxYvpxSJ_7Edy75YC4CH7tBVA6_vEQdbKFqQXnI9is3eQ_yv8HtgyRKA</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Howard, G.C.W.</creator><creator>Conkey, D.S.</creator><creator>Peoples, S.</creator><creator>McLaren, D.B.</creator><creator>Hargreave, T.B.</creator><creator>Tulloch, D.N.</creator><creator>Walker, W.</creator><creator>Kerr, G.R.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>The Management and Outcome of Patients with Germ-cell Tumours Treated in the Edinburgh Cancer Centre Between 1988 and 2002</title><author>Howard, G.C.W. ; Conkey, D.S. ; Peoples, S. ; McLaren, D.B. ; Hargreave, T.B. ; Tulloch, D.N. ; Walker, W. ; Kerr, G.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-f9d95ce0145a73fbaaf4e0d26753df050ab3c8757aa8664599578b3e84bdde583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Combined Modality Therapy</topic><topic>Disease-Free Survival</topic><topic>Germ-cell tumours</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Germ Cell and Embryonal - mortality</topic><topic>Neoplasms, Germ Cell and Embryonal - pathology</topic><topic>Neoplasms, Germ Cell and Embryonal - therapy</topic><topic>prognostic group</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><topic>testicular cancer</topic><topic>Testicular Neoplasms - mortality</topic><topic>Testicular Neoplasms - pathology</topic><topic>Testicular Neoplasms - therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Howard, G.C.W.</creatorcontrib><creatorcontrib>Conkey, D.S.</creatorcontrib><creatorcontrib>Peoples, S.</creatorcontrib><creatorcontrib>McLaren, D.B.</creatorcontrib><creatorcontrib>Hargreave, T.B.</creatorcontrib><creatorcontrib>Tulloch, D.N.</creatorcontrib><creatorcontrib>Walker, W.</creatorcontrib><creatorcontrib>Kerr, G.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oncology (Royal College of Radiologists (Great Britain))</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Howard, G.C.W.</au><au>Conkey, D.S.</au><au>Peoples, S.</au><au>McLaren, D.B.</au><au>Hargreave, T.B.</au><au>Tulloch, D.N.</au><au>Walker, W.</au><au>Kerr, G.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Management and Outcome of Patients with Germ-cell Tumours Treated in the Edinburgh Cancer Centre Between 1988 and 2002</atitle><jtitle>Clinical oncology (Royal College of Radiologists (Great Britain))</jtitle><addtitle>Clin Oncol (R Coll Radiol)</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>17</volume><issue>6</issue><spage>435</spage><epage>440</epage><pages>435-440</pages><issn>0936-6555</issn><eissn>1433-2981</eissn><abstract>The aim of this retrospective analysis was to review the outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre over the past 15 years, and to see whether there had been any changes over three 5-year cohorts.
Patients referred with gonadal and extra-gonadal primary germ-cell tumours, between 1988 and 2002, were identified from the departmental database, and survival by stage and prognostic group was analysed.
The proportion of patients with stage I seminoma has significantly increased. The good prognosis of patients with early stage disease is confirmed, with the outcome for some groups of patients being better than expected. There is a non-significant trend to improved results over the three 5-year cohorts. The outcome for patients with stage IV seminoma is worse than would be expected, but numbers are small. The poor prognosis of patients with non-seminomatous germ-cell tumours who fall into the International Germ Cell Consensus Classification (IGCCC) poor-prognostic group is confirmed. Failure of patients with metastatic non-seminomatous germ-cell tumours to achieve a complete response to initial therapy is shown to be a poor prognostic indicator.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16149287</pmid><doi>10.1016/j.clon.2005.03.011</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical oncology (Royal College of Radiologists (Great Britain)), 2005-09, Vol.17 (6), p.435-440 |
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| subjects | Adolescent Adult Aged Combined Modality Therapy Disease-Free Survival Germ-cell tumours Humans Male Middle Aged Neoplasm Staging Neoplasms, Germ Cell and Embryonal - mortality Neoplasms, Germ Cell and Embryonal - pathology Neoplasms, Germ Cell and Embryonal - therapy prognostic group Retrospective Studies Risk Factors Survival Rate testicular cancer Testicular Neoplasms - mortality Testicular Neoplasms - pathology Testicular Neoplasms - therapy Treatment Outcome |
| title | The Management and Outcome of Patients with Germ-cell Tumours Treated in the Edinburgh Cancer Centre Between 1988 and 2002 |
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