Level IIb Lymph Nodes Metastasis in Elective Supraomohyoid Neck Dissection for Oral Cavity Squamous Cell Carcinoma: A Molecular-Based Study
Objectives: To identify the incidence of level IIb lymph nodes metastasis in elective supraomohyoid neck dissection (SOHND) as a treatment for patients with squamous cell carcinoma (SCC) of the oral cavity. Study Design: Prospective analysis of a case series. Methods: Forty‐eight patients with SCC o...
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| Veröffentlicht in: | The Laryngoscope 2005-09, Vol.115 (9), p.1636-1640 |
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| creator | Elsheikh, Mohamed Nasser Mahfouz, Magdy Elsayed Elsheikh, Ehab |
| description | Objectives: To identify the incidence of level IIb lymph nodes metastasis in elective supraomohyoid neck dissection (SOHND) as a treatment for patients with squamous cell carcinoma (SCC) of the oral cavity.
Study Design: Prospective analysis of a case series.
Methods: Forty‐eight patients with SCC of the oral cavity and with no palpable lymph nodes at the neck who underwent an elective SOHND were prospectively studied. The incidence of micrometastasis to level IIb lymph nodes after performing elective SOHND was evaluated by pathologic examination and molecular analysis.
Results: Of the 48 patients, 15 (31%) by pathologic analysis and 22 (46%) by molecular analysis had lymph nodes positive for metastatic SCC. By molecular analysis, 5 (10%) of the 48 patients had involvement of level IIb lymph nodes. All patients with metastasis to level IIb lymph nodes have their primary lesions in the tongue and constituted 22% of patients with tongue lesions. There was no instance of isolated metastasis to level IIb lymph nodes without involvement of other nodes in the SOHND specimens.
Conclusions: In this study, level IIb lymph node metastasis was only found in association with tongue carcinoma. Although this region may be preserved in elective SOHND in patients with SCC of the oral cavity, it should be included whenever the tongue is the primary site. |
| doi_str_mv | 10.1097/01.mlg.0000176540.33486.c3 |
| format | Article |
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Study Design: Prospective analysis of a case series.
Methods: Forty‐eight patients with SCC of the oral cavity and with no palpable lymph nodes at the neck who underwent an elective SOHND were prospectively studied. The incidence of micrometastasis to level IIb lymph nodes after performing elective SOHND was evaluated by pathologic examination and molecular analysis.
Results: Of the 48 patients, 15 (31%) by pathologic analysis and 22 (46%) by molecular analysis had lymph nodes positive for metastatic SCC. By molecular analysis, 5 (10%) of the 48 patients had involvement of level IIb lymph nodes. All patients with metastasis to level IIb lymph nodes have their primary lesions in the tongue and constituted 22% of patients with tongue lesions. There was no instance of isolated metastasis to level IIb lymph nodes without involvement of other nodes in the SOHND specimens.
Conclusions: In this study, level IIb lymph node metastasis was only found in association with tongue carcinoma. Although this region may be preserved in elective SOHND in patients with SCC of the oral cavity, it should be included whenever the tongue is the primary site.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1097/01.mlg.0000176540.33486.c3</identifier><identifier>PMID: 16148709</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Biological and medical sciences ; Carcinoma, Squamous Cell - surgery ; cytokeratin 20 ; Elective Surgical Procedures ; Electrophoresis ; Female ; Humans ; Intermediate Filament Proteins ; Keratin-20 ; Lymphatic Metastasis - pathology ; Male ; Medical sciences ; Middle Aged ; Mouth Neoplasms - surgery ; Neck Dissection - methods ; neck metastasis ; Nucleic Acid Amplification Techniques ; Oral cavity carcinoma ; Otorhinolaryngology. Stomatology ; Prospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - analysis ; RT-PCR ; selective neck dissection ; Tongue Neoplasms - pathology ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>The Laryngoscope, 2005-09, Vol.115 (9), p.1636-1640</ispartof><rights>Copyright © 2005 The Triological Society</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5141-8676c7cc9eac9628f4c2b0bb24af1c2c5d37d3a341ef2ec4f2f33471da246ec83</citedby><cites>FETCH-LOGICAL-c5141-8676c7cc9eac9628f4c2b0bb24af1c2c5d37d3a341ef2ec4f2f33471da246ec83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2F01.mlg.0000176540.33486.c3$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2F01.mlg.0000176540.33486.c3$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17111766$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16148709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elsheikh, Mohamed Nasser</creatorcontrib><creatorcontrib>Mahfouz, Magdy Elsayed</creatorcontrib><creatorcontrib>Elsheikh, Ehab</creatorcontrib><title>Level IIb Lymph Nodes Metastasis in Elective Supraomohyoid Neck Dissection for Oral Cavity Squamous Cell Carcinoma: A Molecular-Based Study</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives: To identify the incidence of level IIb lymph nodes metastasis in elective supraomohyoid neck dissection (SOHND) as a treatment for patients with squamous cell carcinoma (SCC) of the oral cavity.
Study Design: Prospective analysis of a case series.
Methods: Forty‐eight patients with SCC of the oral cavity and with no palpable lymph nodes at the neck who underwent an elective SOHND were prospectively studied. The incidence of micrometastasis to level IIb lymph nodes after performing elective SOHND was evaluated by pathologic examination and molecular analysis.
Results: Of the 48 patients, 15 (31%) by pathologic analysis and 22 (46%) by molecular analysis had lymph nodes positive for metastatic SCC. By molecular analysis, 5 (10%) of the 48 patients had involvement of level IIb lymph nodes. All patients with metastasis to level IIb lymph nodes have their primary lesions in the tongue and constituted 22% of patients with tongue lesions. There was no instance of isolated metastasis to level IIb lymph nodes without involvement of other nodes in the SOHND specimens.
Conclusions: In this study, level IIb lymph node metastasis was only found in association with tongue carcinoma. Although this region may be preserved in elective SOHND in patients with SCC of the oral cavity, it should be included whenever the tongue is the primary site.</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>cytokeratin 20</subject><subject>Elective Surgical Procedures</subject><subject>Electrophoresis</subject><subject>Female</subject><subject>Humans</subject><subject>Intermediate Filament Proteins</subject><subject>Keratin-20</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - surgery</subject><subject>Neck Dissection - methods</subject><subject>neck metastasis</subject><subject>Nucleic Acid Amplification Techniques</subject><subject>Oral cavity carcinoma</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prospective Studies</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - analysis</subject><subject>RT-PCR</subject><subject>selective neck dissection</subject><subject>Tongue Neoplasms - pathology</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd9u0zAUhyMEYmXwCshCgrsUH_9LsruurF2ltkN0iHFluY7DzJK6s5OyPAMvjUsreo1lyZL9nc9H55ck7wAPARfZRwzDpv4xxHFBJjjDQ0pZLoaaPksGwCmkrCj482SAMaFpzsndWfIqhJ97nHL8MjkDASzPcDFIfs_NztRoNlujed9s79HSlSaghWlViNsGZDfoqja6tTuDVt3WK9e4-97ZEi2NfkCfbAj7V7dBlfPoxqsajdXOtj1aPXaqcV1AY1PvL722G9eoCzRCCxeVXa18eqmCKdGq7cr-dfKiUnUwb47nefJ1cnU7vk7nN9PZeDRPNQcGaS4yoTOtC6N0IUheMU3WeL0mTFWgieYlzUqqKANTEaNZRao4nwxKRZgwOqfnyYeDd-vdY2dCKxsbdOxRbUxsV4qcCyIAR_DiAGrvQvCmkltvG-V7CVjuo5AYZIxCnqKQf6OQmsbit8dfunVjylPpcfYReH8EVNCqrrzaaBtOXAYQnSJykwP3y9am_48W5Hz05TvnDIDjgkAUpQeRDa15-idS_kGKjGZcfltO5efF9C6_nSzliv4BgvC4Ow</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Elsheikh, Mohamed Nasser</creator><creator>Mahfouz, Magdy Elsayed</creator><creator>Elsheikh, Ehab</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200509</creationdate><title>Level IIb Lymph Nodes Metastasis in Elective Supraomohyoid Neck Dissection for Oral Cavity Squamous Cell Carcinoma: A Molecular-Based Study</title><author>Elsheikh, Mohamed Nasser ; Mahfouz, Magdy Elsayed ; Elsheikh, Ehab</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5141-8676c7cc9eac9628f4c2b0bb24af1c2c5d37d3a341ef2ec4f2f33471da246ec83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>cytokeratin 20</topic><topic>Elective Surgical Procedures</topic><topic>Electrophoresis</topic><topic>Female</topic><topic>Humans</topic><topic>Intermediate Filament Proteins</topic><topic>Keratin-20</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - surgery</topic><topic>Neck Dissection - methods</topic><topic>neck metastasis</topic><topic>Nucleic Acid Amplification Techniques</topic><topic>Oral cavity carcinoma</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prospective Studies</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - analysis</topic><topic>RT-PCR</topic><topic>selective neck dissection</topic><topic>Tongue Neoplasms - pathology</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elsheikh, Mohamed Nasser</creatorcontrib><creatorcontrib>Mahfouz, Magdy Elsayed</creatorcontrib><creatorcontrib>Elsheikh, Ehab</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elsheikh, Mohamed Nasser</au><au>Mahfouz, Magdy Elsayed</au><au>Elsheikh, Ehab</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Level IIb Lymph Nodes Metastasis in Elective Supraomohyoid Neck Dissection for Oral Cavity Squamous Cell Carcinoma: A Molecular-Based Study</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2005-09</date><risdate>2005</risdate><volume>115</volume><issue>9</issue><spage>1636</spage><epage>1640</epage><pages>1636-1640</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Objectives: To identify the incidence of level IIb lymph nodes metastasis in elective supraomohyoid neck dissection (SOHND) as a treatment for patients with squamous cell carcinoma (SCC) of the oral cavity.
Study Design: Prospective analysis of a case series.
Methods: Forty‐eight patients with SCC of the oral cavity and with no palpable lymph nodes at the neck who underwent an elective SOHND were prospectively studied. The incidence of micrometastasis to level IIb lymph nodes after performing elective SOHND was evaluated by pathologic examination and molecular analysis.
Results: Of the 48 patients, 15 (31%) by pathologic analysis and 22 (46%) by molecular analysis had lymph nodes positive for metastatic SCC. By molecular analysis, 5 (10%) of the 48 patients had involvement of level IIb lymph nodes. All patients with metastasis to level IIb lymph nodes have their primary lesions in the tongue and constituted 22% of patients with tongue lesions. There was no instance of isolated metastasis to level IIb lymph nodes without involvement of other nodes in the SOHND specimens.
Conclusions: In this study, level IIb lymph node metastasis was only found in association with tongue carcinoma. Although this region may be preserved in elective SOHND in patients with SCC of the oral cavity, it should be included whenever the tongue is the primary site.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>16148709</pmid><doi>10.1097/01.mlg.0000176540.33486.c3</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Carcinoma, Squamous Cell - surgery cytokeratin 20 Elective Surgical Procedures Electrophoresis Female Humans Intermediate Filament Proteins Keratin-20 Lymphatic Metastasis - pathology Male Medical sciences Middle Aged Mouth Neoplasms - surgery Neck Dissection - methods neck metastasis Nucleic Acid Amplification Techniques Oral cavity carcinoma Otorhinolaryngology. Stomatology Prospective Studies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis RT-PCR selective neck dissection Tongue Neoplasms - pathology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Level IIb Lymph Nodes Metastasis in Elective Supraomohyoid Neck Dissection for Oral Cavity Squamous Cell Carcinoma: A Molecular-Based Study |
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