Wnt signaling pathway and lung disease
The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival, apoptosis, and cell motility. Loss of regulation of these pathways can lea...
Gespeichert in:
| Veröffentlicht in: | Translational research : the journal of laboratory and clinical medicine 2008-04, Vol.151 (4), p.175-180 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 180 |
|---|---|
| container_issue | 4 |
| container_start_page | 175 |
| container_title | Translational research : the journal of laboratory and clinical medicine |
| container_volume | 151 |
| creator | Van Scoyk, Michelle Randall, Jessica Sergew, Amen Williams, Lisa M Tennis, Meredith Winn, Robert A |
| description | The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival, apoptosis, and cell motility. Loss of regulation of these pathways can lead to tumorigenesis, and the Wnt pathway has been implicated in the development of several types of cancers, including colon, lung, leukemia, breast, thyroid, and prostate. The Wnt pathway has also been associated with other lung diseases such as interstitial lung disease (ILD) and asthma. Our increasing understanding of the Wnt pathway offers great hope that new molecular-based screening tests and pharmaceutical agents that selectively target this pathway will be developed to diagnose and treat these diseases in the future. |
| doi_str_mv | 10.1016/j.trsl.2007.12.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68562299</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1931524408000029</els_id><sourcerecordid>68562299</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-5e65f87c97544046e03303a5f64f504ba3f3b591712a35c7625e6c7b15f07c1d3</originalsourceid><addsrcrecordid>eNp9kU1L7DAUhoNc8fsPuJBZuWs9Jx9NCyJc5PoBggsVlyGTnmrGTjs3ab3MvzdlBi64MJuE8D5vyHMYO0XIEbC4WORDiG3OAXSOPAfEHXaApS4zLBF-pXMlMFNcyn12GOMCQBYVyD22j6VQShfygJ2_dsMs-rfOtr57m63s8P7Prme2q2ftmC5qH8lGOma7jW0jnWz3I_Zy8-f5-i57eLy9v_79kDkJ1ZApKlRTaldpJWV6jUAIEFY1hWwUyLkVjZirCjVyK5TTBU-E03NUDWiHtThi55veVej_jhQHs_TRUdvajvoxmqJUBedVlYJ8E3ShjzFQY1bBL21YGwQz2TELM9kxkx2D3CQ7CTrbto_zJdX_ka2OFLjcBCj98dNTMNF56hzVPpAbTN37n_uvvuEuWfXOth-0prjox5A8R4MmJsA8TfOZxgMlpMUr8QUPHoiI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68562299</pqid></control><display><type>article</type><title>Wnt signaling pathway and lung disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Van Scoyk, Michelle ; Randall, Jessica ; Sergew, Amen ; Williams, Lisa M ; Tennis, Meredith ; Winn, Robert A</creator><creatorcontrib>Van Scoyk, Michelle ; Randall, Jessica ; Sergew, Amen ; Williams, Lisa M ; Tennis, Meredith ; Winn, Robert A</creatorcontrib><description>The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival, apoptosis, and cell motility. Loss of regulation of these pathways can lead to tumorigenesis, and the Wnt pathway has been implicated in the development of several types of cancers, including colon, lung, leukemia, breast, thyroid, and prostate. The Wnt pathway has also been associated with other lung diseases such as interstitial lung disease (ILD) and asthma. Our increasing understanding of the Wnt pathway offers great hope that new molecular-based screening tests and pharmaceutical agents that selectively target this pathway will be developed to diagnose and treat these diseases in the future.</description><identifier>ISSN: 1931-5244</identifier><identifier>EISSN: 1878-1810</identifier><identifier>DOI: 10.1016/j.trsl.2007.12.011</identifier><identifier>PMID: 18355764</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Drug Design ; Humans ; Internal Medicine ; Lung Diseases - physiopathology ; Lung Neoplasms - physiopathology ; Signal Transduction ; Wnt Proteins - drug effects ; Wnt Proteins - physiology</subject><ispartof>Translational research : the journal of laboratory and clinical medicine, 2008-04, Vol.151 (4), p.175-180</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-5e65f87c97544046e03303a5f64f504ba3f3b591712a35c7625e6c7b15f07c1d3</citedby><cites>FETCH-LOGICAL-c409t-5e65f87c97544046e03303a5f64f504ba3f3b591712a35c7625e6c7b15f07c1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1931524408000029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18355764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Scoyk, Michelle</creatorcontrib><creatorcontrib>Randall, Jessica</creatorcontrib><creatorcontrib>Sergew, Amen</creatorcontrib><creatorcontrib>Williams, Lisa M</creatorcontrib><creatorcontrib>Tennis, Meredith</creatorcontrib><creatorcontrib>Winn, Robert A</creatorcontrib><title>Wnt signaling pathway and lung disease</title><title>Translational research : the journal of laboratory and clinical medicine</title><addtitle>Transl Res</addtitle><description>The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival, apoptosis, and cell motility. Loss of regulation of these pathways can lead to tumorigenesis, and the Wnt pathway has been implicated in the development of several types of cancers, including colon, lung, leukemia, breast, thyroid, and prostate. The Wnt pathway has also been associated with other lung diseases such as interstitial lung disease (ILD) and asthma. Our increasing understanding of the Wnt pathway offers great hope that new molecular-based screening tests and pharmaceutical agents that selectively target this pathway will be developed to diagnose and treat these diseases in the future.</description><subject>Drug Design</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lung Diseases - physiopathology</subject><subject>Lung Neoplasms - physiopathology</subject><subject>Signal Transduction</subject><subject>Wnt Proteins - drug effects</subject><subject>Wnt Proteins - physiology</subject><issn>1931-5244</issn><issn>1878-1810</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1L7DAUhoNc8fsPuJBZuWs9Jx9NCyJc5PoBggsVlyGTnmrGTjs3ab3MvzdlBi64MJuE8D5vyHMYO0XIEbC4WORDiG3OAXSOPAfEHXaApS4zLBF-pXMlMFNcyn12GOMCQBYVyD22j6VQShfygJ2_dsMs-rfOtr57m63s8P7Prme2q2ftmC5qH8lGOma7jW0jnWz3I_Zy8-f5-i57eLy9v_79kDkJ1ZApKlRTaldpJWV6jUAIEFY1hWwUyLkVjZirCjVyK5TTBU-E03NUDWiHtThi55veVej_jhQHs_TRUdvajvoxmqJUBedVlYJ8E3ShjzFQY1bBL21YGwQz2TELM9kxkx2D3CQ7CTrbto_zJdX_ka2OFLjcBCj98dNTMNF56hzVPpAbTN37n_uvvuEuWfXOth-0prjox5A8R4MmJsA8TfOZxgMlpMUr8QUPHoiI</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Van Scoyk, Michelle</creator><creator>Randall, Jessica</creator><creator>Sergew, Amen</creator><creator>Williams, Lisa M</creator><creator>Tennis, Meredith</creator><creator>Winn, Robert A</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Wnt signaling pathway and lung disease</title><author>Van Scoyk, Michelle ; Randall, Jessica ; Sergew, Amen ; Williams, Lisa M ; Tennis, Meredith ; Winn, Robert A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-5e65f87c97544046e03303a5f64f504ba3f3b591712a35c7625e6c7b15f07c1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Drug Design</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lung Diseases - physiopathology</topic><topic>Lung Neoplasms - physiopathology</topic><topic>Signal Transduction</topic><topic>Wnt Proteins - drug effects</topic><topic>Wnt Proteins - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Scoyk, Michelle</creatorcontrib><creatorcontrib>Randall, Jessica</creatorcontrib><creatorcontrib>Sergew, Amen</creatorcontrib><creatorcontrib>Williams, Lisa M</creatorcontrib><creatorcontrib>Tennis, Meredith</creatorcontrib><creatorcontrib>Winn, Robert A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Translational research : the journal of laboratory and clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Scoyk, Michelle</au><au>Randall, Jessica</au><au>Sergew, Amen</au><au>Williams, Lisa M</au><au>Tennis, Meredith</au><au>Winn, Robert A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wnt signaling pathway and lung disease</atitle><jtitle>Translational research : the journal of laboratory and clinical medicine</jtitle><addtitle>Transl Res</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>151</volume><issue>4</issue><spage>175</spage><epage>180</epage><pages>175-180</pages><issn>1931-5244</issn><eissn>1878-1810</eissn><abstract>The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival, apoptosis, and cell motility. Loss of regulation of these pathways can lead to tumorigenesis, and the Wnt pathway has been implicated in the development of several types of cancers, including colon, lung, leukemia, breast, thyroid, and prostate. The Wnt pathway has also been associated with other lung diseases such as interstitial lung disease (ILD) and asthma. Our increasing understanding of the Wnt pathway offers great hope that new molecular-based screening tests and pharmaceutical agents that selectively target this pathway will be developed to diagnose and treat these diseases in the future.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>18355764</pmid><doi>10.1016/j.trsl.2007.12.011</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1931-5244 |
| ispartof | Translational research : the journal of laboratory and clinical medicine, 2008-04, Vol.151 (4), p.175-180 |
| issn | 1931-5244 1878-1810 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68562299 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Drug Design Humans Internal Medicine Lung Diseases - physiopathology Lung Neoplasms - physiopathology Signal Transduction Wnt Proteins - drug effects Wnt Proteins - physiology |
| title | Wnt signaling pathway and lung disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T06%3A20%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Wnt%20signaling%20pathway%20and%20lung%20disease&rft.jtitle=Translational%20research%20:%20the%20journal%20of%20laboratory%20and%20clinical%20medicine&rft.au=Van%20Scoyk,%20Michelle&rft.date=2008-04-01&rft.volume=151&rft.issue=4&rft.spage=175&rft.epage=180&rft.pages=175-180&rft.issn=1931-5244&rft.eissn=1878-1810&rft_id=info:doi/10.1016/j.trsl.2007.12.011&rft_dat=%3Cproquest_cross%3E68562299%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68562299&rft_id=info:pmid/18355764&rft_els_id=S1931524408000029&rfr_iscdi=true |