Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos

Epigenetic reprogramming is a prerequisite process during mammalian development that is aberrant in cloned embryos. However, mechanisms that evolve abnormal epigenetic reprogramming during preimplantation development are unclear. To trace the molecular event of an epigenetic mark such as DNA methyla...

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Veröffentlicht in:	Reproduction (Cambridge, England) England), 2007-12, Vol.134 (6), p.781-787
Hauptverfasser:	Wee, Gabbine, Shim, Jung-Jae, Koo, Deog-Bon, Chae, Jung-Il, Lee, Kyung-Kwang, Han, Yong-Mahn
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blastocyst - cytology Blastocyst - metabolism Cattle Cell Cycle Cells, Cultured Cloning, Organism - methods DNA Methylation DNA, Satellite - genetics Embryonic Development Epigenesis, Genetic Female Fertilization in Vitro Fibroblasts - drug effects Fibroblasts - transplantation Hydroxamic Acids - pharmacology Karyotyping Nuclear Transfer Techniques Protein Synthesis Inhibitors - pharmacology
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