Hypoxia Impairs Systemic Endothelial Function in Individuals Prone to High-Altitude Pulmonary Edema

High-altitude pulmonary edema (HAPE) is characterized by excessive pulmonary vasoconstriction and is associated with decreased concentrations of nitric oxide (NO) in the lung. We hypothesized that individuals susceptible to HAPE (HAPE-S) would also have dysfunction of the vascular NO vasodilator pat...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2005-09, Vol.172 (6), p.763-767
Hauptverfasser:	Berger, Marc M, Hesse, Christiane, Dehnert, Christoph, Siedler, Heike, Kleinbongard, Petra, Bardenheuer, Hubert J, Kelm, Malte, Bartsch, Peter, Haefeli, Walter E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Adult Altitude Sickness - etiology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Disease Susceptibility Endothelin-1 - blood Endothelium, Vascular - physiopathology Female Forearm - blood supply Hemodynamics Humans Hypoxia - blood Hypoxia - physiopathology Intensive care medicine Male Medical sciences Middle Aged Nitrates - blood Nitrites - blood Nitroprusside - pharmacology Pneumology Pulmonary Artery - physiopathology Pulmonary Edema - etiology Pulmonary Gas Exchange Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Regional Blood Flow Single-Blind Method Vasodilation Vasodilator Agents - pharmacology
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