Dose-dependent pharmacokinetic study of genistein in Beagle dogs
To study the pharmacokinetics of genistein at different doses in Beagle dogs. Suspended in 0.5% CMC-Na solution, genistein was orally administered to Beagle dogs at doses of 2.67, 5.34 and 10.68 mg.kg(-1). At various time intervals, 1.5 mL of blood was drawn from the femoral vein of dogs in their fr...
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| Veröffentlicht in: | Yao hsüeh hsüeh pao 2005-06, Vol.40 (6), p.553-556 |
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| container_title | Yao hsüeh hsüeh pao |
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| creator | Zhou, Si-Yuan Mei, Qi-Bing Wang, Ru-Tao Wang, Qing-Wei Yang, Zhi-Fu Wang, Si-Wang |
| description | To study the pharmacokinetics of genistein at different doses in Beagle dogs.
Suspended in 0.5% CMC-Na solution, genistein was orally administered to Beagle dogs at doses of 2.67, 5.34 and 10.68 mg.kg(-1). At various time intervals, 1.5 mL of blood was drawn from the femoral vein of dogs in their front legs. The plasma was treated with beta-glucuronidase. The genistein in plasma was extracted twice by vortexing with 2.0 mL mixture of methyl tert-tubtyl ether and pentane (v/v = 8:2). The organic phase was removed into the tubes and then evaporated in ventilation cabinet. The residue was dissolved in 50 microL of methanol. 20 microL solution was drawn and detected by high-performance liquid chromatography. The pharmacokinetic parameters were calculated by 3P97 software.
The plasma drug concentration-time data were fitted to the two-compartment model. When the dose was 2.67 mg.kg(-1), the MRT and AUC of parent compound were 52.9 min and 6.7 mg.min. L(-1), respectively. When the dose rose to 5.34 mg.kg(-1), the M |
| format | Article |
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Suspended in 0.5% CMC-Na solution, genistein was orally administered to Beagle dogs at doses of 2.67, 5.34 and 10.68 mg.kg(-1). At various time intervals, 1.5 mL of blood was drawn from the femoral vein of dogs in their front legs. The plasma was treated with beta-glucuronidase. The genistein in plasma was extracted twice by vortexing with 2.0 mL mixture of methyl tert-tubtyl ether and pentane (v/v = 8:2). The organic phase was removed into the tubes and then evaporated in ventilation cabinet. The residue was dissolved in 50 microL of methanol. 20 microL solution was drawn and detected by high-performance liquid chromatography. The pharmacokinetic parameters were calculated by 3P97 software.
The plasma drug concentration-time data were fitted to the two-compartment model. When the dose was 2.67 mg.kg(-1), the MRT and AUC of parent compound were 52.9 min and 6.7 mg.min. L(-1), respectively. When the dose rose to 5.34 mg.kg(-1), the M</description><identifier>ISSN: 0513-4870</identifier><identifier>PMID: 16144324</identifier><language>chi</language><publisher>China</publisher><subject>Animals ; Anticarcinogenic Agents - administration & dosage ; Anticarcinogenic Agents - blood ; Anticarcinogenic Agents - pharmacokinetics ; Area Under Curve ; Dogs ; Dose-Response Relationship, Drug ; Female ; Genistein - administration & dosage ; Genistein - blood ; Genistein - pharmacokinetics ; Glucuronides - blood ; Glucuronides - pharmacokinetics ; Male</subject><ispartof>Yao hsüeh hsüeh pao, 2005-06, Vol.40 (6), p.553-556</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16144324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Si-Yuan</creatorcontrib><creatorcontrib>Mei, Qi-Bing</creatorcontrib><creatorcontrib>Wang, Ru-Tao</creatorcontrib><creatorcontrib>Wang, Qing-Wei</creatorcontrib><creatorcontrib>Yang, Zhi-Fu</creatorcontrib><creatorcontrib>Wang, Si-Wang</creatorcontrib><title>Dose-dependent pharmacokinetic study of genistein in Beagle dogs</title><title>Yao hsüeh hsüeh pao</title><addtitle>Yao Xue Xue Bao</addtitle><description>To study the pharmacokinetics of genistein at different doses in Beagle dogs.
Suspended in 0.5% CMC-Na solution, genistein was orally administered to Beagle dogs at doses of 2.67, 5.34 and 10.68 mg.kg(-1). At various time intervals, 1.5 mL of blood was drawn from the femoral vein of dogs in their front legs. The plasma was treated with beta-glucuronidase. The genistein in plasma was extracted twice by vortexing with 2.0 mL mixture of methyl tert-tubtyl ether and pentane (v/v = 8:2). The organic phase was removed into the tubes and then evaporated in ventilation cabinet. The residue was dissolved in 50 microL of methanol. 20 microL solution was drawn and detected by high-performance liquid chromatography. The pharmacokinetic parameters were calculated by 3P97 software.
The plasma drug concentration-time data were fitted to the two-compartment model. When the dose was 2.67 mg.kg(-1), the MRT and AUC of parent compound were 52.9 min and 6.7 mg.min. L(-1), respectively. When the dose rose to 5.34 mg.kg(-1), the M</description><subject>Animals</subject><subject>Anticarcinogenic Agents - administration & dosage</subject><subject>Anticarcinogenic Agents - blood</subject><subject>Anticarcinogenic Agents - pharmacokinetics</subject><subject>Area Under Curve</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Genistein - administration & dosage</subject><subject>Genistein - blood</subject><subject>Genistein - pharmacokinetics</subject><subject>Glucuronides - blood</subject><subject>Glucuronides - pharmacokinetics</subject><subject>Male</subject><issn>0513-4870</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j01LxDAYhHNQ3HX1L0hO3gpvvtruTV11FRa86LkkzZsabZPapIf99xZcYWCG4WFgzsgaFBOFrCtYkcuUvgAk24r6gqxYyaQUXK7J3WNMWFgcMVgMmY6fehp0G799wOxbmvJsjzQ62mHwKaMPdNED6q5HamOXrsi5033C65NvyMfz0_vupTi87V9394diZFzmAgEUKG6ZLTnjrTS83UoAziqmwGy1MLVZcrV0TgrrnANTGqYBBXOlqcSG3P7tjlP8mTHlZvCpxb7XAeOcmrJWapFawJsTOJsBbTNOftDTsfn_LH4BOQ5QxQ</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Zhou, Si-Yuan</creator><creator>Mei, Qi-Bing</creator><creator>Wang, Ru-Tao</creator><creator>Wang, Qing-Wei</creator><creator>Yang, Zhi-Fu</creator><creator>Wang, Si-Wang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Dose-dependent pharmacokinetic study of genistein in Beagle dogs</title><author>Zhou, Si-Yuan ; Mei, Qi-Bing ; Wang, Ru-Tao ; Wang, Qing-Wei ; Yang, Zhi-Fu ; Wang, Si-Wang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-e005052d1d6212c4b2c9400217150b9a3b8b1717400f43dfff0b6b1a0e31f6b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Anticarcinogenic Agents - administration & dosage</topic><topic>Anticarcinogenic Agents - blood</topic><topic>Anticarcinogenic Agents - pharmacokinetics</topic><topic>Area Under Curve</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Genistein - administration & dosage</topic><topic>Genistein - blood</topic><topic>Genistein - pharmacokinetics</topic><topic>Glucuronides - blood</topic><topic>Glucuronides - pharmacokinetics</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Si-Yuan</creatorcontrib><creatorcontrib>Mei, Qi-Bing</creatorcontrib><creatorcontrib>Wang, Ru-Tao</creatorcontrib><creatorcontrib>Wang, Qing-Wei</creatorcontrib><creatorcontrib>Yang, Zhi-Fu</creatorcontrib><creatorcontrib>Wang, Si-Wang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Yao hsüeh hsüeh pao</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Si-Yuan</au><au>Mei, Qi-Bing</au><au>Wang, Ru-Tao</au><au>Wang, Qing-Wei</au><au>Yang, Zhi-Fu</au><au>Wang, Si-Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose-dependent pharmacokinetic study of genistein in Beagle dogs</atitle><jtitle>Yao hsüeh hsüeh pao</jtitle><addtitle>Yao Xue Xue Bao</addtitle><date>2005-06</date><risdate>2005</risdate><volume>40</volume><issue>6</issue><spage>553</spage><epage>556</epage><pages>553-556</pages><issn>0513-4870</issn><abstract>To study the pharmacokinetics of genistein at different doses in Beagle dogs.
Suspended in 0.5% CMC-Na solution, genistein was orally administered to Beagle dogs at doses of 2.67, 5.34 and 10.68 mg.kg(-1). At various time intervals, 1.5 mL of blood was drawn from the femoral vein of dogs in their front legs. The plasma was treated with beta-glucuronidase. The genistein in plasma was extracted twice by vortexing with 2.0 mL mixture of methyl tert-tubtyl ether and pentane (v/v = 8:2). The organic phase was removed into the tubes and then evaporated in ventilation cabinet. The residue was dissolved in 50 microL of methanol. 20 microL solution was drawn and detected by high-performance liquid chromatography. The pharmacokinetic parameters were calculated by 3P97 software.
The plasma drug concentration-time data were fitted to the two-compartment model. When the dose was 2.67 mg.kg(-1), the MRT and AUC of parent compound were 52.9 min and 6.7 mg.min. L(-1), respectively. When the dose rose to 5.34 mg.kg(-1), the M</abstract><cop>China</cop><pmid>16144324</pmid><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Anticarcinogenic Agents - administration & dosage Anticarcinogenic Agents - blood Anticarcinogenic Agents - pharmacokinetics Area Under Curve Dogs Dose-Response Relationship, Drug Female Genistein - administration & dosage Genistein - blood Genistein - pharmacokinetics Glucuronides - blood Glucuronides - pharmacokinetics Male |
| title | Dose-dependent pharmacokinetic study of genistein in Beagle dogs |
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