Evidence for p62 aggregate formation: Role in cell survival

The polyubiquitin-binding protein p62 has been shown to localize in aggregates common to several types of diseases. Here, we report that p62 forms independent fibrillar aggregates in vitro in a time- and concentration-dependent manner. FTIR spectra and ThT fluorescence assay of p62 reveals increased...

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Veröffentlicht in:FEBS letters 2005-09, Vol.579 (22), p.5029-5034
Hauptverfasser: Paine, Michael G., Ramesh Babu, J., Seibenhener, M. Lamar, Wooten, Marie W.
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Sprache:eng
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