Enantioselective metabolism of trans-4-hydroxy-2-nonenal by brain mitochondria

Trans-4-hydroxy-2-nonenal (HNE) is a product of lipid peroxidation with many cellular effects. HNE possesses a stereogenic center at the C4 carbon that influences the metabolism and alkylation targets of HNE. We tested the hypothesis that rat brain mitochondria metabolize HNE in an enantioselective...

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Veröffentlicht in:	Free radical biology & medicine 2005-10, Vol.39 (7), p.913-924
Hauptverfasser:	Honzatko, Ales, Brichac, Jiri, Murphy, Tonya C, Reberg, Alexander, Kubátová, Alena, Smoliakova, Irina P, Picklo, Sr, Matthew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - isolation & purification Aldehydes - metabolism Animals Brain - ultrastructure Carbidopa - chemistry Chromatography, High Pressure Liquid - methods Hydroxy Acids - metabolism Male Mitochondria - metabolism Rats Rats, Sprague-Dawley Stereoisomerism
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