Folate Receptor-Mediated Drug Targeting: From Therapeutics to Diagnostics

Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its small molecular size and high binding affinity for cell surface folate receptors (FR), folate conjugates have the ability to deliver a variety of mo...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2005-10, Vol.94 (10), p.2135-2146
Hauptverfasser:	Hilgenbrink, Andrew R., Low, Philip S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use arthritis Biological and medical sciences Biomarkers, Tumor - metabolism cancer chemotherapy Carrier Proteins - metabolism Drug Delivery Systems folate conjugate folate receptor Folate Receptors, GPI-Anchored Folic Acid - administration & dosage Folic Acid - chemistry General pharmacology Humans imaging methods Immunotherapy inflammatory disease Liposomes Medical sciences nanoparticles Nanostructures Neoplasms - diagnostic imaging Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - therapy Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Radionuclide Imaging Radiopharmaceuticals Receptors, Cell Surface - metabolism targeted drug delivery Toxins, Biological - administration & dosage Toxins, Biological - therapeutic use
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