Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts
Background: The clinical outcome of treatment of odontogenic cysts differs depending on separate entities. Particular clinical relevance must be attached to the distinction between odontogenic keratocysts, which have an evident tendency to recur, and other odontogenic cysts. The aim of this study w...
Gespeichert in:
| Veröffentlicht in: | Journal of oral pathology & medicine 2005-10, Vol.34 (9), p.558-564 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 564 |
|---|---|
| container_issue | 9 |
| container_start_page | 558 |
| container_title | Journal of oral pathology & medicine |
| container_volume | 34 |
| creator | Stoll, Christian Stollenwerk, Carolin Riediger, Dieter Mittermayer, Christian Alfer, Joachim |
| description | Background: The clinical outcome of treatment of odontogenic cysts differs depending on separate entities. Particular clinical relevance must be attached to the distinction between odontogenic keratocysts, which have an evident tendency to recur, and other odontogenic cysts. The aim of this study was to evaluate cytokeratin (CK) expression patterns as an additional tool for characterization of different cysts as the histomorphologic appearance often is not decisive.
Methods: Thirty cases of dentigerous and radicular cysts respectively as well as 15 cases of odontogenic keratocysts were considered. Expression of CK 5/6, 7, 10, 13, 17, 19 and 20 was determined in addition to Ki‐67 immunohistochemically.
Results: Expression of CK 17 was discernible in 93.3% of the odontogenic keratocysts, but only in 35.0% of dentigerous and radicular cysts under study (P |
| doi_str_mv | 10.1111/j.1600-0714.2005.00352.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68555046</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68555046</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5502-dfcea66264a1c09295f3d07fe73dadd67201127520ff2d2b50f5fe7aa7f2bb23</originalsourceid><addsrcrecordid>eNqNkc1uEzEUhS1ERUPhFZA3sJvh2jO2ZyQ2KKIFFLUIKoHYWI5_KqeTcbAdNXl7PEnUbuuNLZ3v-FydixAmUJNyPq5qwgEqEKStKQCrARpG690LNHsUXqIZ9NBWlBF6jl6ntAIgomnJK3ROOGm6rmczFOb7HO5tVNmP2O420abkw4g3Kmcbx4RdiNj4VGSdJyE4HEwYc7izo9f4YA16n3JBY1hjY8fs72wM24TVaHBUxuvtoCI-QG_QmVNDsm9P9wW6vfxyO_9aLW6uvs0_LyrNGNDKOG0V55S3imjoac9cY0A4KxqjjOGCAiFUMArOUUOXDBwrolLC0eWSNhfow_HbTQz_tjZlufZJ22FQoy2TSd6xktPyAnZHUMeQUrRObqJfq7iXBOTUtVzJqVI5VSqnruWha7kr1nenjO1ybc2T8VRuAd6fAJW0GlxUo_bpiRMgGkH7wn06cg9-sPtnDyC_3_woj2KvjvayJbt7tKt4L3kJYPL39ZX8C9e_usWfn7Jv_gP-vayD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68555046</pqid></control><display><type>article</type><title>Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Stoll, Christian ; Stollenwerk, Carolin ; Riediger, Dieter ; Mittermayer, Christian ; Alfer, Joachim</creator><creatorcontrib>Stoll, Christian ; Stollenwerk, Carolin ; Riediger, Dieter ; Mittermayer, Christian ; Alfer, Joachim</creatorcontrib><description>Background: The clinical outcome of treatment of odontogenic cysts differs depending on separate entities. Particular clinical relevance must be attached to the distinction between odontogenic keratocysts, which have an evident tendency to recur, and other odontogenic cysts. The aim of this study was to evaluate cytokeratin (CK) expression patterns as an additional tool for characterization of different cysts as the histomorphologic appearance often is not decisive.
Methods: Thirty cases of dentigerous and radicular cysts respectively as well as 15 cases of odontogenic keratocysts were considered. Expression of CK 5/6, 7, 10, 13, 17, 19 and 20 was determined in addition to Ki‐67 immunohistochemically.
Results: Expression of CK 17 was discernible in 93.3% of the odontogenic keratocysts, but only in 35.0% of dentigerous and radicular cysts under study (P < 0.001). CK 19 could be detected in 48.3% of dentigerous and radicular cysts, whereas odontogenic keratocysts were completely negative (P < 0.002).
Conclusion: Immunohistochemical detection of CK 17 and 19 seems to be a valuable additional parameter distinguishing between odontogenic keratocysts and other odontogenic – especially dentigerous – cysts which clinically are likely the most significant differential diagnoses in this context.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.2005.00352.x</identifier><identifier>PMID: 16138895</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biomarkers - analysis ; Child ; cytokeratin ; dentigerous cyst ; Dentigerous Cyst - classification ; Dentigerous Cyst - pathology ; Dentistry ; Diagnosis, Differential ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Humans ; Immunohistochemistry ; Intermediate Filament Proteins - analysis ; Keratin-20 ; Keratin-7 ; Keratins - analysis ; keratocyst ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases ; odontogenic ; Odontogenic Cysts - classification ; Odontogenic Cysts - pathology ; Otorhinolaryngology. Stomatology ; radicular cyst ; Radicular Cyst - classification ; Radicular Cyst - pathology</subject><ispartof>Journal of oral pathology & medicine, 2005-10, Vol.34 (9), p.558-564</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5502-dfcea66264a1c09295f3d07fe73dadd67201127520ff2d2b50f5fe7aa7f2bb23</citedby><cites>FETCH-LOGICAL-c5502-dfcea66264a1c09295f3d07fe73dadd67201127520ff2d2b50f5fe7aa7f2bb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0714.2005.00352.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0714.2005.00352.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17073729$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16138895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stoll, Christian</creatorcontrib><creatorcontrib>Stollenwerk, Carolin</creatorcontrib><creatorcontrib>Riediger, Dieter</creatorcontrib><creatorcontrib>Mittermayer, Christian</creatorcontrib><creatorcontrib>Alfer, Joachim</creatorcontrib><title>Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Background: The clinical outcome of treatment of odontogenic cysts differs depending on separate entities. Particular clinical relevance must be attached to the distinction between odontogenic keratocysts, which have an evident tendency to recur, and other odontogenic cysts. The aim of this study was to evaluate cytokeratin (CK) expression patterns as an additional tool for characterization of different cysts as the histomorphologic appearance often is not decisive.
Methods: Thirty cases of dentigerous and radicular cysts respectively as well as 15 cases of odontogenic keratocysts were considered. Expression of CK 5/6, 7, 10, 13, 17, 19 and 20 was determined in addition to Ki‐67 immunohistochemically.
Results: Expression of CK 17 was discernible in 93.3% of the odontogenic keratocysts, but only in 35.0% of dentigerous and radicular cysts under study (P < 0.001). CK 19 could be detected in 48.3% of dentigerous and radicular cysts, whereas odontogenic keratocysts were completely negative (P < 0.002).
Conclusion: Immunohistochemical detection of CK 17 and 19 seems to be a valuable additional parameter distinguishing between odontogenic keratocysts and other odontogenic – especially dentigerous – cysts which clinically are likely the most significant differential diagnoses in this context.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Child</subject><subject>cytokeratin</subject><subject>dentigerous cyst</subject><subject>Dentigerous Cyst - classification</subject><subject>Dentigerous Cyst - pathology</subject><subject>Dentistry</subject><subject>Diagnosis, Differential</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intermediate Filament Proteins - analysis</subject><subject>Keratin-20</subject><subject>Keratin-7</subject><subject>Keratins - analysis</subject><subject>keratocyst</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>odontogenic</subject><subject>Odontogenic Cysts - classification</subject><subject>Odontogenic Cysts - pathology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>radicular cyst</subject><subject>Radicular Cyst - classification</subject><subject>Radicular Cyst - pathology</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1uEzEUhS1ERUPhFZA3sJvh2jO2ZyQ2KKIFFLUIKoHYWI5_KqeTcbAdNXl7PEnUbuuNLZ3v-FydixAmUJNyPq5qwgEqEKStKQCrARpG690LNHsUXqIZ9NBWlBF6jl6ntAIgomnJK3ROOGm6rmczFOb7HO5tVNmP2O420abkw4g3Kmcbx4RdiNj4VGSdJyE4HEwYc7izo9f4YA16n3JBY1hjY8fs72wM24TVaHBUxuvtoCI-QG_QmVNDsm9P9wW6vfxyO_9aLW6uvs0_LyrNGNDKOG0V55S3imjoac9cY0A4KxqjjOGCAiFUMArOUUOXDBwrolLC0eWSNhfow_HbTQz_tjZlufZJ22FQoy2TSd6xktPyAnZHUMeQUrRObqJfq7iXBOTUtVzJqVI5VSqnruWha7kr1nenjO1ybc2T8VRuAd6fAJW0GlxUo_bpiRMgGkH7wn06cg9-sPtnDyC_3_woj2KvjvayJbt7tKt4L3kJYPL39ZX8C9e_usWfn7Jv_gP-vayD</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Stoll, Christian</creator><creator>Stollenwerk, Carolin</creator><creator>Riediger, Dieter</creator><creator>Mittermayer, Christian</creator><creator>Alfer, Joachim</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts</title><author>Stoll, Christian ; Stollenwerk, Carolin ; Riediger, Dieter ; Mittermayer, Christian ; Alfer, Joachim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5502-dfcea66264a1c09295f3d07fe73dadd67201127520ff2d2b50f5fe7aa7f2bb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Child</topic><topic>cytokeratin</topic><topic>dentigerous cyst</topic><topic>Dentigerous Cyst - classification</topic><topic>Dentigerous Cyst - pathology</topic><topic>Dentistry</topic><topic>Diagnosis, Differential</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intermediate Filament Proteins - analysis</topic><topic>Keratin-20</topic><topic>Keratin-7</topic><topic>Keratins - analysis</topic><topic>keratocyst</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>odontogenic</topic><topic>Odontogenic Cysts - classification</topic><topic>Odontogenic Cysts - pathology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>radicular cyst</topic><topic>Radicular Cyst - classification</topic><topic>Radicular Cyst - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stoll, Christian</creatorcontrib><creatorcontrib>Stollenwerk, Carolin</creatorcontrib><creatorcontrib>Riediger, Dieter</creatorcontrib><creatorcontrib>Mittermayer, Christian</creatorcontrib><creatorcontrib>Alfer, Joachim</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stoll, Christian</au><au>Stollenwerk, Carolin</au><au>Riediger, Dieter</au><au>Mittermayer, Christian</au><au>Alfer, Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2005-10</date><risdate>2005</risdate><volume>34</volume><issue>9</issue><spage>558</spage><epage>564</epage><pages>558-564</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Background: The clinical outcome of treatment of odontogenic cysts differs depending on separate entities. Particular clinical relevance must be attached to the distinction between odontogenic keratocysts, which have an evident tendency to recur, and other odontogenic cysts. The aim of this study was to evaluate cytokeratin (CK) expression patterns as an additional tool for characterization of different cysts as the histomorphologic appearance often is not decisive.
Methods: Thirty cases of dentigerous and radicular cysts respectively as well as 15 cases of odontogenic keratocysts were considered. Expression of CK 5/6, 7, 10, 13, 17, 19 and 20 was determined in addition to Ki‐67 immunohistochemically.
Results: Expression of CK 17 was discernible in 93.3% of the odontogenic keratocysts, but only in 35.0% of dentigerous and radicular cysts under study (P < 0.001). CK 19 could be detected in 48.3% of dentigerous and radicular cysts, whereas odontogenic keratocysts were completely negative (P < 0.002).
Conclusion: Immunohistochemical detection of CK 17 and 19 seems to be a valuable additional parameter distinguishing between odontogenic keratocysts and other odontogenic – especially dentigerous – cysts which clinically are likely the most significant differential diagnoses in this context.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>16138895</pmid><doi>10.1111/j.1600-0714.2005.00352.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0904-2512 |
| ispartof | Journal of oral pathology & medicine, 2005-10, Vol.34 (9), p.558-564 |
| issn | 0904-2512 1600-0714 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68555046 |
| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Adult Aged Biological and medical sciences Biomarkers - analysis Child cytokeratin dentigerous cyst Dentigerous Cyst - classification Dentigerous Cyst - pathology Dentistry Diagnosis, Differential Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Humans Immunohistochemistry Intermediate Filament Proteins - analysis Keratin-20 Keratin-7 Keratins - analysis keratocyst Male Medical sciences Middle Aged Non tumoral diseases odontogenic Odontogenic Cysts - classification Odontogenic Cysts - pathology Otorhinolaryngology. Stomatology radicular cyst Radicular Cyst - classification Radicular Cyst - pathology |
| title | Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A19%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytokeratin%20expression%20patterns%20for%20distinction%20of%20odontogenic%20keratocysts%20from%20dentigerous%20and%20radicular%20cysts&rft.jtitle=Journal%20of%20oral%20pathology%20&%20medicine&rft.au=Stoll,%20Christian&rft.date=2005-10&rft.volume=34&rft.issue=9&rft.spage=558&rft.epage=564&rft.pages=558-564&rft.issn=0904-2512&rft.eissn=1600-0714&rft_id=info:doi/10.1111/j.1600-0714.2005.00352.x&rft_dat=%3Cproquest_cross%3E68555046%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68555046&rft_id=info:pmid/16138895&rfr_iscdi=true |