Unchanged glutamine synthetase activity and increased NMDA receptor density in epileptic human neocortex: Implications for the pathophysiology of epilepsy

We investigated whether alterations in glutamate metabolising glutamine synthetase activity occur in human epileptic neocortex, as shown previously for human epileptic hippocampus [Eid, T., Thomas, M.J., Spencer, D.D., Rundén-Pran, E., Lai, J.C.K., Malthankar, G.V., Kim, J.H., Danbolt, N.C., Otterse...

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Veröffentlicht in:	Neurochemistry international 2005-11, Vol.47 (6), p.379-384
Hauptverfasser:	Steffens, Marc, Huppertz, Hans-Jürgen, Zentner, Josef, Chauzit, Emmanuelle, Feuerstein, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Amygdala - metabolism Amygdala - physiopathology Binding, Competitive Biological and medical sciences Child Child, Preschool Epilepsy Epilepsy - metabolism Epilepsy - physiopathology Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - physiopathology Female Fundamental and applied biological sciences. Psychology Glutamate-Ammonia Ligase - metabolism Glutamic Acid - metabolism Glutamine synthetase Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Human brain Humans Infant Male Medical sciences Middle Aged MK801 Neocortex - metabolism Neocortex - physiopathology Nervous system (semeiology, syndromes) Neurology NMDA receptor Radioligand Assay Receptor Aggregation - physiology Receptors, N-Methyl-D-Aspartate - metabolism Synaptic Membranes - metabolism Synaptic Transmission - physiology Synaptosomes - metabolism Up-Regulation - physiology Vertebrates: nervous system and sense organs
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