Enhanced expressions of endometrial tumour necrosis factor alpha and its receptors during early pregnancy in bonnet monkeys
Tumour necrosis factor alpha (TNF-α), a pro-inflammatory cytokine may play an active role in stimulating inflammatory reactions during pregnancy. However, the expression of endometrial TNF-α has not been investigated especially during early pregnancy, a phenomenon invariably accompanied by inflammat...
Gespeichert in:
| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2005-09, Vol.31 (6), p.459-464 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 464 |
|---|---|
| container_issue | 6 |
| container_start_page | 459 |
| container_title | Cytokine (Philadelphia, Pa.) |
| container_volume | 31 |
| creator | Rosario, Gracy X. Sachdeva, Geetanjali Manjramkar, Dhananjay D. Puri, Chander P. |
| description | Tumour necrosis factor alpha (TNF-α), a pro-inflammatory cytokine may play an active role in stimulating inflammatory reactions during pregnancy. However, the expression of endometrial TNF-α has not been investigated especially during early pregnancy, a phenomenon invariably accompanied by inflammatory reaction. In the present study, the endometrial expressions of TNF-α and its receptors (TNFR1 and TNFR2) during early pregnancy, when the embryo lies free in the zona hatched state in the uterine lumen, were analyzed by immunohistochemistry. The endometrial expressions of TNF-α, TNFR1 and TNFR2 were found to be significantly up-regulated (
p
<
0.05) in the glandular epithelium on day 6 post-ovulation in pregnant animals. The alteration in the expression of these molecules may contribute to the induction of local inflammatory reactions during implantation. |
| doi_str_mv | 10.1016/j.cyto.2005.07.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68554519</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1043466605002322</els_id><sourcerecordid>17060022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-b5161cca45012340a2c5894f7e6e55951b7f4d144f5006d111fd6f85aba4d1a93</originalsourceid><addsrcrecordid>eNqFkU2L1TAUhos4OF_-AReSlbvWkzZJW3Ajw6gDA26cdUjTk5lc26QmqUyZP2_KveBOVwmH57wJ71MU7yhUFKj4eKj0lnxVA_AK2gqgeVVcUOhFCVA3r_c7a0omhDgvLmM8AEDftO2b4pwKSmve8Yvi5dY9KadxJPi8BIzReheJNwTd6GdMwaqJpHX2ayAOdfDRRmKUTj4QNS1Piig3EpsiCahxyeNIxjVY90hQhWkjOfTR5Rc2Yh0ZvHOYyOzdT9zidXFm1BTx7em8Kh6-3P64-Vbef_96d_P5vtRNx1M58PxdrRXjQOuGgao173pmWhTIec_p0Bo2UsYMBxAjpdSMwnRcDSqPVd9cFR-OuUvwv1aMSc42apwm5dCvUYqOc8bp_0HagsjV1hmsj-BeSAxo5BLsrMImKcjdjTzI3Y3c3UhoZXaTl96f0tdhxvHvyklGBj4dAcxl_LYYZNQWdzk2l5vk6O2_8v8AfR2iew</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17060022</pqid></control><display><type>article</type><title>Enhanced expressions of endometrial tumour necrosis factor alpha and its receptors during early pregnancy in bonnet monkeys</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Rosario, Gracy X. ; Sachdeva, Geetanjali ; Manjramkar, Dhananjay D. ; Puri, Chander P.</creator><creatorcontrib>Rosario, Gracy X. ; Sachdeva, Geetanjali ; Manjramkar, Dhananjay D. ; Puri, Chander P.</creatorcontrib><description>Tumour necrosis factor alpha (TNF-α), a pro-inflammatory cytokine may play an active role in stimulating inflammatory reactions during pregnancy. However, the expression of endometrial TNF-α has not been investigated especially during early pregnancy, a phenomenon invariably accompanied by inflammatory reaction. In the present study, the endometrial expressions of TNF-α and its receptors (TNFR1 and TNFR2) during early pregnancy, when the embryo lies free in the zona hatched state in the uterine lumen, were analyzed by immunohistochemistry. The endometrial expressions of TNF-α, TNFR1 and TNFR2 were found to be significantly up-regulated (
p
<
0.05) in the glandular epithelium on day 6 post-ovulation in pregnant animals. The alteration in the expression of these molecules may contribute to the induction of local inflammatory reactions during implantation.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2005.07.003</identifier><identifier>PMID: 16112585</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Bonnet monkeys ; Early pregnancy ; Embryo Implantation ; Endometrium - immunology ; Female ; Immunohistochemistry ; Inflammation ; Macaca radiata ; Pregnancy ; Pregnancy, Animal - immunology ; Receptors, Tumor Necrosis Factor - isolation & purification ; Receptors, Tumor Necrosis Factor - metabolism ; Signal Transduction ; TNF-α ; TNFR1 ; TNFR2 ; Tumor Necrosis Factor-alpha - isolation & purification ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Cytokine (Philadelphia, Pa.), 2005-09, Vol.31 (6), p.459-464</ispartof><rights>2005 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-b5161cca45012340a2c5894f7e6e55951b7f4d144f5006d111fd6f85aba4d1a93</citedby><cites>FETCH-LOGICAL-c385t-b5161cca45012340a2c5894f7e6e55951b7f4d144f5006d111fd6f85aba4d1a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cyto.2005.07.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16112585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosario, Gracy X.</creatorcontrib><creatorcontrib>Sachdeva, Geetanjali</creatorcontrib><creatorcontrib>Manjramkar, Dhananjay D.</creatorcontrib><creatorcontrib>Puri, Chander P.</creatorcontrib><title>Enhanced expressions of endometrial tumour necrosis factor alpha and its receptors during early pregnancy in bonnet monkeys</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>Tumour necrosis factor alpha (TNF-α), a pro-inflammatory cytokine may play an active role in stimulating inflammatory reactions during pregnancy. However, the expression of endometrial TNF-α has not been investigated especially during early pregnancy, a phenomenon invariably accompanied by inflammatory reaction. In the present study, the endometrial expressions of TNF-α and its receptors (TNFR1 and TNFR2) during early pregnancy, when the embryo lies free in the zona hatched state in the uterine lumen, were analyzed by immunohistochemistry. The endometrial expressions of TNF-α, TNFR1 and TNFR2 were found to be significantly up-regulated (
p
<
0.05) in the glandular epithelium on day 6 post-ovulation in pregnant animals. The alteration in the expression of these molecules may contribute to the induction of local inflammatory reactions during implantation.</description><subject>Animals</subject><subject>Bonnet monkeys</subject><subject>Early pregnancy</subject><subject>Embryo Implantation</subject><subject>Endometrium - immunology</subject><subject>Female</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Macaca radiata</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - immunology</subject><subject>Receptors, Tumor Necrosis Factor - isolation & purification</subject><subject>Receptors, Tumor Necrosis Factor - metabolism</subject><subject>Signal Transduction</subject><subject>TNF-α</subject><subject>TNFR1</subject><subject>TNFR2</subject><subject>Tumor Necrosis Factor-alpha - isolation & purification</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhos4OF_-AReSlbvWkzZJW3Ajw6gDA26cdUjTk5lc26QmqUyZP2_KveBOVwmH57wJ71MU7yhUFKj4eKj0lnxVA_AK2gqgeVVcUOhFCVA3r_c7a0omhDgvLmM8AEDftO2b4pwKSmve8Yvi5dY9KadxJPi8BIzReheJNwTd6GdMwaqJpHX2ayAOdfDRRmKUTj4QNS1Piig3EpsiCahxyeNIxjVY90hQhWkjOfTR5Rc2Yh0ZvHOYyOzdT9zidXFm1BTx7em8Kh6-3P64-Vbef_96d_P5vtRNx1M58PxdrRXjQOuGgao173pmWhTIec_p0Bo2UsYMBxAjpdSMwnRcDSqPVd9cFR-OuUvwv1aMSc42apwm5dCvUYqOc8bp_0HagsjV1hmsj-BeSAxo5BLsrMImKcjdjTzI3Y3c3UhoZXaTl96f0tdhxvHvyklGBj4dAcxl_LYYZNQWdzk2l5vk6O2_8v8AfR2iew</recordid><startdate>20050921</startdate><enddate>20050921</enddate><creator>Rosario, Gracy X.</creator><creator>Sachdeva, Geetanjali</creator><creator>Manjramkar, Dhananjay D.</creator><creator>Puri, Chander P.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050921</creationdate><title>Enhanced expressions of endometrial tumour necrosis factor alpha and its receptors during early pregnancy in bonnet monkeys</title><author>Rosario, Gracy X. ; Sachdeva, Geetanjali ; Manjramkar, Dhananjay D. ; Puri, Chander P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-b5161cca45012340a2c5894f7e6e55951b7f4d144f5006d111fd6f85aba4d1a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Bonnet monkeys</topic><topic>Early pregnancy</topic><topic>Embryo Implantation</topic><topic>Endometrium - immunology</topic><topic>Female</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Macaca radiata</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - immunology</topic><topic>Receptors, Tumor Necrosis Factor - isolation & purification</topic><topic>Receptors, Tumor Necrosis Factor - metabolism</topic><topic>Signal Transduction</topic><topic>TNF-α</topic><topic>TNFR1</topic><topic>TNFR2</topic><topic>Tumor Necrosis Factor-alpha - isolation & purification</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosario, Gracy X.</creatorcontrib><creatorcontrib>Sachdeva, Geetanjali</creatorcontrib><creatorcontrib>Manjramkar, Dhananjay D.</creatorcontrib><creatorcontrib>Puri, Chander P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosario, Gracy X.</au><au>Sachdeva, Geetanjali</au><au>Manjramkar, Dhananjay D.</au><au>Puri, Chander P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced expressions of endometrial tumour necrosis factor alpha and its receptors during early pregnancy in bonnet monkeys</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2005-09-21</date><risdate>2005</risdate><volume>31</volume><issue>6</issue><spage>459</spage><epage>464</epage><pages>459-464</pages><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>Tumour necrosis factor alpha (TNF-α), a pro-inflammatory cytokine may play an active role in stimulating inflammatory reactions during pregnancy. However, the expression of endometrial TNF-α has not been investigated especially during early pregnancy, a phenomenon invariably accompanied by inflammatory reaction. In the present study, the endometrial expressions of TNF-α and its receptors (TNFR1 and TNFR2) during early pregnancy, when the embryo lies free in the zona hatched state in the uterine lumen, were analyzed by immunohistochemistry. The endometrial expressions of TNF-α, TNFR1 and TNFR2 were found to be significantly up-regulated (
p
<
0.05) in the glandular epithelium on day 6 post-ovulation in pregnant animals. The alteration in the expression of these molecules may contribute to the induction of local inflammatory reactions during implantation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16112585</pmid><doi>10.1016/j.cyto.2005.07.003</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-4666 |
| ispartof | Cytokine (Philadelphia, Pa.), 2005-09, Vol.31 (6), p.459-464 |
| issn | 1043-4666 1096-0023 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68554519 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Bonnet monkeys Early pregnancy Embryo Implantation Endometrium - immunology Female Immunohistochemistry Inflammation Macaca radiata Pregnancy Pregnancy, Animal - immunology Receptors, Tumor Necrosis Factor - isolation & purification Receptors, Tumor Necrosis Factor - metabolism Signal Transduction TNF-α TNFR1 TNFR2 Tumor Necrosis Factor-alpha - isolation & purification Tumor Necrosis Factor-alpha - metabolism |
| title | Enhanced expressions of endometrial tumour necrosis factor alpha and its receptors during early pregnancy in bonnet monkeys |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T02%3A10%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enhanced%20expressions%20of%20endometrial%20tumour%20necrosis%20factor%20alpha%20and%20its%20receptors%20during%20early%20pregnancy%20in%20bonnet%20monkeys&rft.jtitle=Cytokine%20(Philadelphia,%20Pa.)&rft.au=Rosario,%20Gracy%20X.&rft.date=2005-09-21&rft.volume=31&rft.issue=6&rft.spage=459&rft.epage=464&rft.pages=459-464&rft.issn=1043-4666&rft.eissn=1096-0023&rft_id=info:doi/10.1016/j.cyto.2005.07.003&rft_dat=%3Cproquest_cross%3E17060022%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17060022&rft_id=info:pmid/16112585&rft_els_id=S1043466605002322&rfr_iscdi=true |