Poly-l-proline type II peptide mimics as probes of the active site occupancy requirements of cGMP-dependent protein kinase

:  Based on the X‐ray crystal structure of cAMP‐dependent protein kinase (PKA) with the endogenous inhibitor PKI and the X‐ray crystal structure of cyclin‐dependent kinase 2 (CDK2) with a substrate peptide, a proposal is put forth that some protein kinases bind peptide substrates in their active sit...

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Veröffentlicht in:	The journal of peptide research 2005-10, Vol.66 (4), p.151-159
Hauptverfasser:	Zhang, R., Nickl, C. K., Mamai, A., Flemer, S., Natarajan, A., Dostmann, W. R., Madalengoitia, J.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic Domain - physiology Cyclic GMP-Dependent Protein Kinases - chemistry Cyclic GMP-Dependent Protein Kinases - metabolism Molecular Probes - metabolism peptide mimics Peptides - metabolism PKG poly-L-proline protein kinase Protein Structure, Tertiary
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