Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 1)

Elevated plasma levels of low-density lipoprotein (LDL) cholesterol are a major risk factor for atherosclerosis leading to coronary artery disease (CAD), which remains the main cause of mortality in Western society. We believe that by preventing the reabsorption of bile acids, a minimally absorbed a...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-09, Vol.48 (18), p.5837-5852
Hauptverfasser:	Tremont, Samuel J, Lee, Len F, Huang, Horng-Chih, Keller, Bradley T, Banerjee, Shyamal C, Both, Scott R, Carpenter, Andrew J, Wang, Ching-Cheng, Garland, Danny J, Huang, Wei, Jones, Claude, Koeller, Kevin J, Kolodziej, Steve A, Li, James, Manning, Robert E, Mahoney, Matthew W, Miller, Raymond E, Mischke, Deborah A, Rath, Nigam P, Fletcher, Theresa, Reinhard, Emily J, Tollefson, Michael B, Vernier, William F, Wagner, Grace M, Rapp, Steve R, Beaudry, Judy, Glenn, Kevin, Regina, Karen, Schuh, Joe R, Smith, Mark E, Trivedi, Jay S, Reitz, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - chemical synthesis Anticholesteremic Agents - chemistry Anticholesteremic Agents - pharmacology Benzothiepins - chemical synthesis Benzothiepins - chemistry Benzothiepins - pharmacology Bile Acids and Salts - metabolism Biological and medical sciences Biological Availability Cell Line Cricetinae Crystallography, X-Ray General and cellular metabolism. Vitamins Humans Magnetic Resonance Spectroscopy Male Medical sciences Mesocricetus Organic Anion Transporters, Sodium-Dependent - antagonists & inhibitors Pharmacology. Drug treatments Rats Stereoisomerism Structure-Activity Relationship Symporters - antagonists & inhibitors Taurocholic Acid - metabolism
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