Synthesis and inhibitory effect of novel glycyrrhetinic acid derivatives on IL-1 beta-induced prostaglandin E(2) production in normal human dermal fibroblasts

Olean-11,13(18)-dien-3beta,30-diol dihemiphthalate (3), which was derived from glycyrrhetinic acid (GA), has been reported to produce a potent of anti-inflammatory effect in in vivo assays. Using 3 as a lead compound, we attempted to synthesize some modified compounds which varied in the following;...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2005-09, Vol.53 (9), p.1103-1110
Hauptverfasser:	Tsukahara, Michiko, Nishino, Takeshi, Furuhashi, Ikue, Inoue, Hideo, Sato, Toshitsugu, Matsumoto, Hiroatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Dinoprostone - biosynthesis Fibroblasts - drug effects Fibroblasts - metabolism Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - chemical synthesis Glycyrrhetinic Acid - pharmacology Humans Indicators and Reagents Interleukin-1 - antagonists & inhibitors Interleukin-1 - pharmacology Magnetic Resonance Spectroscopy Skin - cytology Skin - drug effects Skin - metabolism
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