Antianaphylactic and Antipruritic Effects of the Flowers of Impatiens textori MIQ
The anti-anaphylactic and anti-pruritic activities of a 35% EtOH extract (IT) of the flowers of Impatiens textori MIQ. were investigated by in vivo assay. IT and apigenin (1), apigenin 7-glucoside (2) and luteolin (3), principal compounds from IT, inhibited compound 48/80 (COM)-induced by blood pres...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2005, Vol.28(9), pp.1786-1790 |
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| creator | Ueda, Yoshimi Oku, Hisae Iinuma, Munekazu Ishiguro, Kyoko |
| description | The anti-anaphylactic and anti-pruritic activities of a 35% EtOH extract (IT) of the flowers of Impatiens textori MIQ. were investigated by in vivo assay. IT and apigenin (1), apigenin 7-glucoside (2) and luteolin (3), principal compounds from IT, inhibited compound 48/80 (COM)-induced by blood pressure (BP) decrease, which was an immunoglobulin (Ig)E-independent anaphylaxis-like response. Compounds 1—3 all inhibited BP decrease induced by IgE-dependent anaphylaxis. Furthermore, IT also inhibited the blood flow (BF) decrease induced by antigen-induced anaphylaxis in actively sensitized mice. IT showed a significant inhibitory effect on scratching behavior induced by COM without a central depressant. IT also significantly inhibited platelet activating factor (PAF)- and serotonin (5-HT)-induced scratching behavior and mitigated protease (PA)-induced scratching behavior. These findings showed that the flowers of I. textori can be utilized as an anti-anaphylactic and anti-pruritic agent in addition to the traditional applications of this plant. |
| doi_str_mv | 10.1248/bpb.28.1786 |
| format | Article |
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IT and apigenin (1), apigenin 7-glucoside (2) and luteolin (3), principal compounds from IT, inhibited compound 48/80 (COM)-induced by blood pressure (BP) decrease, which was an immunoglobulin (Ig)E-independent anaphylaxis-like response. Compounds 1—3 all inhibited BP decrease induced by IgE-dependent anaphylaxis. Furthermore, IT also inhibited the blood flow (BF) decrease induced by antigen-induced anaphylaxis in actively sensitized mice. IT showed a significant inhibitory effect on scratching behavior induced by COM without a central depressant. IT also significantly inhibited platelet activating factor (PAF)- and serotonin (5-HT)-induced scratching behavior and mitigated protease (PA)-induced scratching behavior. These findings showed that the flowers of I. textori can be utilized as an anti-anaphylactic and anti-pruritic agent in addition to the traditional applications of this plant.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.28.1786</identifier><identifier>PMID: 16141562</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Anaphylaxis - drug therapy ; Animals ; anti-anaphylaxis ; anti-pruritus ; apigenin ; apigenin 7-glucoside ; Behavior, Animal - drug effects ; Blood Pressure - drug effects ; Flowers - chemistry ; Hypnotics and Sedatives - pharmacology ; Immunoglobulin E - immunology ; Impatiens - chemistry ; Impatiens textori ; luteolin ; Male ; Mice ; Motor Activity - drug effects ; Muramidase - immunology ; p-Methoxy-N-methylphenethylamine - pharmacology ; Platelet Activating Factor - pharmacology ; Pruritus - drug therapy ; Pruritus - psychology ; Regional Blood Flow - drug effects ; Serotonin - pharmacology</subject><ispartof>Biological and Pharmaceutical Bulletin, 2005, Vol.28(9), pp.1786-1790</ispartof><rights>2005 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c598t-914d006e6e6c168ae58bb5aa005e129a1eac6e41933ab7f6ae4ef59133aec103</citedby><cites>FETCH-LOGICAL-c598t-914d006e6e6c168ae58bb5aa005e129a1eac6e41933ab7f6ae4ef59133aec103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16141562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ueda, Yoshimi</creatorcontrib><creatorcontrib>Oku, Hisae</creatorcontrib><creatorcontrib>Iinuma, Munekazu</creatorcontrib><creatorcontrib>Ishiguro, Kyoko</creatorcontrib><creatorcontrib>Mukogawa Women's University</creatorcontrib><creatorcontrib>aSchool of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>bGifu Pharmaceutical University</creatorcontrib><title>Antianaphylactic and Antipruritic Effects of the Flowers of Impatiens textori MIQ</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The anti-anaphylactic and anti-pruritic activities of a 35% EtOH extract (IT) of the flowers of Impatiens textori MIQ. were investigated by in vivo assay. IT and apigenin (1), apigenin 7-glucoside (2) and luteolin (3), principal compounds from IT, inhibited compound 48/80 (COM)-induced by blood pressure (BP) decrease, which was an immunoglobulin (Ig)E-independent anaphylaxis-like response. Compounds 1—3 all inhibited BP decrease induced by IgE-dependent anaphylaxis. Furthermore, IT also inhibited the blood flow (BF) decrease induced by antigen-induced anaphylaxis in actively sensitized mice. IT showed a significant inhibitory effect on scratching behavior induced by COM without a central depressant. IT also significantly inhibited platelet activating factor (PAF)- and serotonin (5-HT)-induced scratching behavior and mitigated protease (PA)-induced scratching behavior. These findings showed that the flowers of I. textori can be utilized as an anti-anaphylactic and anti-pruritic agent in addition to the traditional applications of this plant.</description><subject>Anaphylaxis - drug therapy</subject><subject>Animals</subject><subject>anti-anaphylaxis</subject><subject>anti-pruritus</subject><subject>apigenin</subject><subject>apigenin 7-glucoside</subject><subject>Behavior, Animal - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Flowers - chemistry</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Immunoglobulin E - immunology</subject><subject>Impatiens - chemistry</subject><subject>Impatiens textori</subject><subject>luteolin</subject><subject>Male</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Muramidase - immunology</subject><subject>p-Methoxy-N-methylphenethylamine - pharmacology</subject><subject>Platelet Activating Factor - pharmacology</subject><subject>Pruritus - drug therapy</subject><subject>Pruritus - psychology</subject><subject>Regional Blood Flow - drug effects</subject><subject>Serotonin - pharmacology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1r3DAQhkVpabZpT70XQ6GX4u2MbdnSrSHkYyGlBHIXsnbc1eK1XEmmzb-vvN4kUAQjZvTonVcjxj4irLGoxLd2bNeFWGMj6ldshWXV5LxA_pqtQKLIa-TijL0LYQ8ADRTlW3aGNVbI62LF7i-GaPWgx91jr020JtPDNpuLo5-8nQtXXUcmhsx1WdxRdt27P-SP6eYw6mhpCFmkv9F5m_3Y3L9nbzrdB_pw2s_Zw_XVw-VtfvfzZnN5cZcbLkXMJVZbgJrSMlgLTVy0LdcagBMWUiNpU1OFsix123S1poo6LjGlZBDKc_ZlkR29-z1RiOpgg6G-1wO5KahacF6kByfw83_g3k1-SNYUVpUsOcpmpr4ulPEuBE-dGr09aP-oENQ8ZpXGrAqh5jEn-tNJc2oPtH1hT3NNwM0CpFNrdO-G3g700tmEprWudypZ5AqgECAVcDjKpyABoWlkNRv7vijtQ9S_6LmV9ulvenqyJZdwvP50ZHbaKxrKf0lepWM</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Ueda, Yoshimi</creator><creator>Oku, Hisae</creator><creator>Iinuma, Munekazu</creator><creator>Ishiguro, Kyoko</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Antianaphylactic and Antipruritic Effects of the Flowers of Impatiens textori MIQ</title><author>Ueda, Yoshimi ; Oku, Hisae ; Iinuma, Munekazu ; Ishiguro, Kyoko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598t-914d006e6e6c168ae58bb5aa005e129a1eac6e41933ab7f6ae4ef59133aec103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anaphylaxis - drug therapy</topic><topic>Animals</topic><topic>anti-anaphylaxis</topic><topic>anti-pruritus</topic><topic>apigenin</topic><topic>apigenin 7-glucoside</topic><topic>Behavior, Animal - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Flowers - chemistry</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Immunoglobulin E - immunology</topic><topic>Impatiens - chemistry</topic><topic>Impatiens textori</topic><topic>luteolin</topic><topic>Male</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Muramidase - immunology</topic><topic>p-Methoxy-N-methylphenethylamine - pharmacology</topic><topic>Platelet Activating Factor - pharmacology</topic><topic>Pruritus - drug therapy</topic><topic>Pruritus - psychology</topic><topic>Regional Blood Flow - drug effects</topic><topic>Serotonin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ueda, Yoshimi</creatorcontrib><creatorcontrib>Oku, Hisae</creatorcontrib><creatorcontrib>Iinuma, Munekazu</creatorcontrib><creatorcontrib>Ishiguro, Kyoko</creatorcontrib><creatorcontrib>Mukogawa Women's University</creatorcontrib><creatorcontrib>aSchool of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>bGifu Pharmaceutical University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ueda, Yoshimi</au><au>Oku, Hisae</au><au>Iinuma, Munekazu</au><au>Ishiguro, Kyoko</au><aucorp>Mukogawa Women's University</aucorp><aucorp>aSchool of Pharmaceutical Sciences</aucorp><aucorp>bGifu Pharmaceutical University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antianaphylactic and Antipruritic Effects of the Flowers of Impatiens textori MIQ</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>28</volume><issue>9</issue><spage>1786</spage><epage>1790</epage><pages>1786-1790</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>The anti-anaphylactic and anti-pruritic activities of a 35% EtOH extract (IT) of the flowers of Impatiens textori MIQ. were investigated by in vivo assay. IT and apigenin (1), apigenin 7-glucoside (2) and luteolin (3), principal compounds from IT, inhibited compound 48/80 (COM)-induced by blood pressure (BP) decrease, which was an immunoglobulin (Ig)E-independent anaphylaxis-like response. Compounds 1—3 all inhibited BP decrease induced by IgE-dependent anaphylaxis. Furthermore, IT also inhibited the blood flow (BF) decrease induced by antigen-induced anaphylaxis in actively sensitized mice. IT showed a significant inhibitory effect on scratching behavior induced by COM without a central depressant. IT also significantly inhibited platelet activating factor (PAF)- and serotonin (5-HT)-induced scratching behavior and mitigated protease (PA)-induced scratching behavior. These findings showed that the flowers of I. textori can be utilized as an anti-anaphylactic and anti-pruritic agent in addition to the traditional applications of this plant.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>16141562</pmid><doi>10.1248/bpb.28.1786</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anaphylaxis - drug therapy Animals anti-anaphylaxis anti-pruritus apigenin apigenin 7-glucoside Behavior, Animal - drug effects Blood Pressure - drug effects Flowers - chemistry Hypnotics and Sedatives - pharmacology Immunoglobulin E - immunology Impatiens - chemistry Impatiens textori luteolin Male Mice Motor Activity - drug effects Muramidase - immunology p-Methoxy-N-methylphenethylamine - pharmacology Platelet Activating Factor - pharmacology Pruritus - drug therapy Pruritus - psychology Regional Blood Flow - drug effects Serotonin - pharmacology |
| title | Antianaphylactic and Antipruritic Effects of the Flowers of Impatiens textori MIQ |
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