Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo

Interference with the microenvironmental growth support is an attractive therapeutic strategy for repressing metastatic tumor growth. Bone is a highly dynamic tissue that is continuously remodeled by bone resorption and subsequent bone formation. Growth factors supporting bone metastatic growth are...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-09, Vol.65 (17), p.7682-7690
Hauptverfasser:	VAN DER PLUIJM, Gabri, QUE, Ivo, SIJMONS, Bianca, BUIJS, Jeroen T, LÖWIK, Clemens W. G. M, WETTERWALD, Antoinette, THALMANN, George N, PAPAPOULOS, Socrates E, CECCHINI, Marco G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Bone and Bones - drug effects Bone and Bones - metabolism Bone Neoplasms - prevention & control Bone Neoplasms - secondary Breast Neoplasms - pathology Cell Growth Processes - physiology Cell Line, Tumor Chemotherapy Diphosphonates - pharmacology Diseases of the osteoarticular system Female Humans Medical sciences Mice Mice, Inbred BALB C Mice, Nude Pharmacology. Drug treatments Tumors of striated muscle and skeleton
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