Effect of serotonin on respiration, cerebral circulation, and blood pressure in rats

The effects of intravenous serotonin on respiration, cerebral circulation, and blood pressure were examined in narcotized rats. Serotonin rapidly decreased local cerebral blood flow (by almost 30%) and blood pressure. Hemodynamic phenomena were accompanied by sharp changes in the respiration pattern...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-01, Vol.139 (1), p.64-67
Hauptverfasser:	Aleksandrin, V V, Tarasova, N N, Tarakanov, I A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Cerebral Cortex - blood supply Cerebrovascular Circulation - drug effects Injections, Intravenous Male Rats Rats, Inbred Strains Respiration - drug effects Serotonin - administration & dosage Serotonin - pharmacology
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Zusammenfassung:	The effects of intravenous serotonin on respiration, cerebral circulation, and blood pressure were examined in narcotized rats. Serotonin rapidly decreased local cerebral blood flow (by almost 30%) and blood pressure. Hemodynamic phenomena were accompanied by sharp changes in the respiration pattern: short-term apnea in all cases. The mechanism of this apnea was related to initial stages in blood pressure changes and had a neurogenic nature.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0213-6