A Comparison of Case‐Control and Family‐Based Association Methods: The Example of Sickle‐Cell and Malaria

Summary There has been much debate about the relative merits of population‐ and family‐based strategies for testing genetic association, yet there is little empirical data that directly compare the two approaches. Here we compare case‐control and transmission/disequilibrium test (TDT) study designs...

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Veröffentlicht in:	Annals of human genetics 2005-09, Vol.69 (5), p.559-565
Hauptverfasser:	Ackerman, H., Usen, S., Jallow, M., Sisay‐Joof, F., Pinder, M., Kwiatkowski, D. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals case control Case-Control Studies Confidence Intervals Disease association Female Fetal Blood - metabolism Gene Frequency Genetics, Population Genotype Globins - metabolism hemoglobin Hemoglobins - metabolism Humans Linkage Disequilibrium malaria Malaria - genetics Male Models, Statistical Odds Ratio plasmodium falciparum Plasmodium falciparum - metabolism Research Design segregation distortion sickle cell Sickle Cell Trait - genetics TDT transmission/disequilibrium test β‐globin
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