Role of nucleophosmin in embryonic development and tumorigenesis

Nucleophosmin (also known as NPM, B23, NO38) is a nucleolar protein directly implicated in cancer pathogenesis, as the NPM1 gene is found mutated and rearranged in a number of haematological disorders. Furthermore, the region of chromosome 5 to which NPM1 maps is deleted in a proportion of de novo h...

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Veröffentlicht in:	Nature 2005-09, Vol.437 (7055), p.147-153
Hauptverfasser:	Grisendi, Silvia, Cheng, Ke, Rossi, Marco, Khandker, Luipa, Manova, Katia, Pandolfi, Pier Paolo, Bernardi, Rosa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Cell Cycle - genetics Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Cells, Cultured Centrosome - metabolism Embryo Loss - genetics Embryonic Development Embryonic growth stage Embryos Fibroblasts Gene Deletion Genomic Instability - genetics Hematology Hematopoiesis - genetics Humanities and Social Sciences In Situ Hybridization, Fluorescence Inactivation letter Mice Mice, Knockout multidisciplinary Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - pathology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Nuclear Proteins - deficiency Nuclear Proteins - genetics Nuclear Proteins - metabolism Pathogens Prenatal development Science Science (multidisciplinary) Tumors
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