Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project
To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnest...
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| Veröffentlicht in: | Dementia and geriatric cognitive disorders 2007-11, Vol.24 (6), p.448-456 |
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| container_title | Dementia and geriatric cognitive disorders |
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| creator | Mariani, E Monastero, R Ercolani, S Mangialasche, F Caputo, M Feliziani, F T Vitale, D F Senin, U Mecocci, P |
| description | To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study.
Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated.
snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.
Our findings suggest that snmMCI may be considered a vascular cognitive disorder. |
| doi_str_mv | 10.1159/000110653 |
| format | Article |
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Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated.
snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.
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Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated.
snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.
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Findings from the ReGAl project</atitle><jtitle>Dementia and geriatric cognitive disorders</jtitle><addtitle>Dement Geriatr Cogn Disord</addtitle><date>2007-11</date><risdate>2007</risdate><volume>24</volume><issue>6</issue><spage>448</spage><epage>456</epage><pages>448-456</pages><issn>1420-8008</issn><eissn>1421-9824</eissn><coden>DGCDFX</coden><abstract>To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study.
Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated.
snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.
Our findings suggest that snmMCI may be considered a vascular cognitive disorder.</abstract><cop>Switzerland</cop><pub>S. Karger AG</pub><pmid>17975314</pmid><doi>10.1159/000110653</doi><tpages>9</tpages></addata></record> |
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| subjects | Activities of Daily Living Aged Atrophy - pathology Brain - pathology Cognition Disorders - classification Cognition Disorders - diagnosis Cognition Disorders - epidemiology Female Humans Ischemic Attack, Transient - epidemiology Magnetic Resonance Imaging Male Neuropsychological Tests Prevalence Risk Assessment Risk Factors Severity of Illness Index Surveys and Questionnaires |
| title | Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project |
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