Dominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII
GluR1 and GluR2 subunits compose AMPA receptors (AMPARs) in the mature hippocampus, and both the GluR1 subunit and Ca2+/calmodulin-dependent protein kinase II (CaMKII) are required for synaptic plasticity, memory and learning. Although GluR1 phosphorylation by CaMKII is preserved, the functional reg...
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| Veröffentlicht in: | Nature neuroscience 2005-07, Vol.8 (7), p.853-854 |
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| creator | Derkach, Victor A Oh, Michael C |
| description | GluR1 and GluR2 subunits compose AMPA receptors (AMPARs) in the mature hippocampus, and both the GluR1 subunit and Ca2+/calmodulin-dependent protein kinase II (CaMKII) are required for synaptic plasticity, memory and learning. Although GluR1 phosphorylation by CaMKII is preserved, the functional regulation of AMPARs by phosphorylation is lost in the presence of the GluR2 subunit. Our findings define a previously unknown, dominant role of the GluR2 subunit in signaling mediated by CaMKII at AMPARs. |
| doi_str_mv | 10.1038/nn1476 |
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Although GluR1 phosphorylation by CaMKII is preserved, the functional regulation of AMPARs by phosphorylation is lost in the presence of the GluR2 subunit. 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Although GluR1 phosphorylation by CaMKII is preserved, the functional regulation of AMPARs by phosphorylation is lost in the presence of the GluR2 subunit. Our findings define a previously unknown, dominant role of the GluR2 subunit in signaling mediated by CaMKII at AMPARs.</abstract><cop>United States</cop><pub>Nature Publishing Group</pub><pmid>15924137</pmid><doi>10.1038/nn1476</doi><tpages>2</tpages></addata></record> |
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| subjects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - pharmacology Calcium-Calmodulin-Dependent Protein Kinases - physiology Cell Line Electric Conductivity Humans Hypotheses Kinases Long-term potentiation Neural transmission Neuroplasticity Phosphorylation Receptors, AMPA - metabolism Receptors, AMPA - physiology Regulation Signal Transduction |
| title | Dominant role of the GluR2 subunit in regulation of AMPA receptors by CaMKII |
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