Randomized Trial of Genotype-Guided Versus Standard Warfarin Dosing in Patients Initiating Oral Anticoagulation

Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials. Consenting patients (n=206) being initiated on warfarin were randomized to pharmacogenetic-guided or standard dosing. Buccal swab DNA was...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2007-11, Vol.116 (22), p.2563-2570
Hauptverfasser:	ANDERSON, Jeffrey L, HORNE, Benjamin D, CARLQUIST, John F, STEVENS, Scott M, GROVE, Amanda S, BARTON, Stephanie, NICHOLAS, Zachery P, KAHN, Samera F. S, MAY, Heidi T, SAMUELSON, Kent M, MUHLESTEIN, Joseph B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Algorithms Anticoagulants - therapeutic use Aryl Hydrocarbon Hydroxylases - genetics Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Cytochrome P-450 CYP2C9 Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Drug Dosage Calculations Drug Monitoring - methods Female Genotype Humans Male Medical sciences Middle Aged Mixed Function Oxygenases - genetics Pharmacogenetics - methods Pharmacology. Drug treatments Treatment Outcome Vascular wall Vasodilator agents. Cerebral vasodilators Vitamin K Epoxide Reductases Warfarin - administration & dosage
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