Outcome in adulthood of asymptomatic airway hyperresponsiveness to histamine and exercise-induced bronchospasm in childhood
Studies of the clinical outcome in adulthood of asymptomatic airway hyperresponsiveness (AHR) to histamine or exercise-induced bronchospasm (EIB) detected in childhood in general population samples are sparse and have produced conflicting results. To describe the outcome of asymptomatic AHR to hista...
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| Veröffentlicht in: | Annals of Allergy, Asthma & Immunology Asthma & Immunology, 2005-08, Vol.95 (2), p.137-142 |
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| container_title | Annals of Allergy, Asthma & Immunology |
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| creator | Porsbjerg, Celeste von Linstow, Marie-Louise Ulrik, Charlotte Slrik Nepper-Christensen, Steen Christian Backer, Vibeke |
| description | Studies of the clinical outcome in adulthood of asymptomatic airway hyperresponsiveness (AHR) to histamine or exercise-induced bronchospasm (EIB) detected in childhood in general population samples are sparse and have produced conflicting results.
To describe the outcome of asymptomatic AHR to histamine and EIB.
Data from a 12-year follow-up study of a random population sample of individuals aged 7 to 17 years at enrollment were analyzed; only individuals without asthma at enrollment were included in the analysis. AHR to inhaled histamine, EIB, lung function, and sensitization to aeroallergens were measured.
Among the 281 nonasthmatic participants studied, 58 (22%) had AHR to histamine, 33 (12%) had EIB, and 82 (29%) had AHR to histamine and/or EIB. At follow-up, 37.9% of individuals with AHR to histamine and 30% of individuals with EIB had developed current asthma, compared with only 5% of individuals in whom these test results were negative. In patients with AHR to histamine, parental asthma (odds ratio [OR], 12.6; 95% confidence interval [CI], 1.5-108.5), furred pets ownership (OR, 6.0; 95% CI, 1.2-19.6), and dermatitis and/or rhinitis in childhood (OR, 2.2; 95% CI, 1.1-5.1) predicted the subsequent development of asthma, whereas no risk factors for the development of asthma could be identified in individuals with EIB
.
Asymptomatic AHR to histamine and EIB in childhood predict the subsequent development of asthma in adulthood. A genetic disposition to asthma, furred pets ownership, and concomitant rhinitis or dermatitis increase the risk of asthma development in individuals with AHR to histamine. |
| doi_str_mv | 10.1016/S1081-1206(10)61202-1 |
| format | Article |
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To describe the outcome of asymptomatic AHR to histamine and EIB.
Data from a 12-year follow-up study of a random population sample of individuals aged 7 to 17 years at enrollment were analyzed; only individuals without asthma at enrollment were included in the analysis. AHR to inhaled histamine, EIB, lung function, and sensitization to aeroallergens were measured.
Among the 281 nonasthmatic participants studied, 58 (22%) had AHR to histamine, 33 (12%) had EIB, and 82 (29%) had AHR to histamine and/or EIB. At follow-up, 37.9% of individuals with AHR to histamine and 30% of individuals with EIB had developed current asthma, compared with only 5% of individuals in whom these test results were negative. In patients with AHR to histamine, parental asthma (odds ratio [OR], 12.6; 95% confidence interval [CI], 1.5-108.5), furred pets ownership (OR, 6.0; 95% CI, 1.2-19.6), and dermatitis and/or rhinitis in childhood (OR, 2.2; 95% CI, 1.1-5.1) predicted the subsequent development of asthma, whereas no risk factors for the development of asthma could be identified in individuals with EIB
.
Asymptomatic AHR to histamine and EIB in childhood predict the subsequent development of asthma in adulthood. A genetic disposition to asthma, furred pets ownership, and concomitant rhinitis or dermatitis increase the risk of asthma development in individuals with AHR to histamine.</description><identifier>ISSN: 1081-1206</identifier><identifier>EISSN: 1534-4436</identifier><identifier>DOI: 10.1016/S1081-1206(10)61202-1</identifier><identifier>PMID: 16136762</identifier><identifier>CODEN: ANAEA3</identifier><language>eng</language><publisher>McLean, VA: Elsevier Inc</publisher><subject>Adolescent ; Asthma - etiology ; Asthma - immunology ; Asthma, Exercise-Induced - complications ; Asthma, Exercise-Induced - immunology ; Biological and medical sciences ; Bronchial Hyperreactivity - complications ; Bronchial Hyperreactivity - immunology ; Child ; Chronic obstructive pulmonary disease, asthma ; Denmark ; Exercise Test ; Female ; Follow-Up Studies ; Histamine - administration & dosage ; Histamine - immunology ; Humans ; Immunopathology ; Male ; Medical sciences ; Multivariate Analysis ; Pneumology ; Regression Analysis ; Respiratory Function Tests ; Risk Factors ; Skin Tests</subject><ispartof>Annals of Allergy, Asthma & Immunology, 2005-08, Vol.95 (2), p.137-142</ispartof><rights>2005 American College of Allergy, Asthma & Immunology</rights><rights>2005 INIST-CNRS</rights><rights>Copyright American College of Allergy and Immunology Aug 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-7a8271a5b338098603763e745e7a7d875ce977aeee0faa3dca11a9f3368da1783</citedby><cites>FETCH-LOGICAL-c451t-7a8271a5b338098603763e745e7a7d875ce977aeee0faa3dca11a9f3368da1783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1081120610612021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17037371$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16136762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Porsbjerg, Celeste</creatorcontrib><creatorcontrib>von Linstow, Marie-Louise</creatorcontrib><creatorcontrib>Ulrik, Charlotte Slrik</creatorcontrib><creatorcontrib>Nepper-Christensen, Steen Christian</creatorcontrib><creatorcontrib>Backer, Vibeke</creatorcontrib><title>Outcome in adulthood of asymptomatic airway hyperresponsiveness to histamine and exercise-induced bronchospasm in childhood</title><title>Annals of Allergy, Asthma & Immunology</title><addtitle>Ann Allergy Asthma Immunol</addtitle><description>Studies of the clinical outcome in adulthood of asymptomatic airway hyperresponsiveness (AHR) to histamine or exercise-induced bronchospasm (EIB) detected in childhood in general population samples are sparse and have produced conflicting results.
To describe the outcome of asymptomatic AHR to histamine and EIB.
Data from a 12-year follow-up study of a random population sample of individuals aged 7 to 17 years at enrollment were analyzed; only individuals without asthma at enrollment were included in the analysis. AHR to inhaled histamine, EIB, lung function, and sensitization to aeroallergens were measured.
Among the 281 nonasthmatic participants studied, 58 (22%) had AHR to histamine, 33 (12%) had EIB, and 82 (29%) had AHR to histamine and/or EIB. At follow-up, 37.9% of individuals with AHR to histamine and 30% of individuals with EIB had developed current asthma, compared with only 5% of individuals in whom these test results were negative. In patients with AHR to histamine, parental asthma (odds ratio [OR], 12.6; 95% confidence interval [CI], 1.5-108.5), furred pets ownership (OR, 6.0; 95% CI, 1.2-19.6), and dermatitis and/or rhinitis in childhood (OR, 2.2; 95% CI, 1.1-5.1) predicted the subsequent development of asthma, whereas no risk factors for the development of asthma could be identified in individuals with EIB
.
Asymptomatic AHR to histamine and EIB in childhood predict the subsequent development of asthma in adulthood. A genetic disposition to asthma, furred pets ownership, and concomitant rhinitis or dermatitis increase the risk of asthma development in individuals with AHR to histamine.</description><subject>Adolescent</subject><subject>Asthma - etiology</subject><subject>Asthma - immunology</subject><subject>Asthma, Exercise-Induced - complications</subject><subject>Asthma, Exercise-Induced - immunology</subject><subject>Biological and medical sciences</subject><subject>Bronchial Hyperreactivity - complications</subject><subject>Bronchial Hyperreactivity - immunology</subject><subject>Child</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Denmark</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Histamine - administration & dosage</subject><subject>Histamine - immunology</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Pneumology</subject><subject>Regression Analysis</subject><subject>Respiratory Function Tests</subject><subject>Risk Factors</subject><subject>Skin Tests</subject><issn>1081-1206</issn><issn>1534-4436</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9rFTEUxYMotlY_ghIEiy5Gk8lMkrcqUvwHhS7UdbgvucOkzCRjMtP68Mubee9JwU1XuYRfzrk5h5CXnL3njMsP3znTvOI1k285eyfLUFf8ETnlrWiqphHycZn_ISfkWc43jDGupXhKTrjkQipZn5I_18ts44jUBwpuGeY-RkdjRyHvxmmOI8zeUvDpDna0302YEuYphuxvMWDOdI6093mG0QekEBzF35isz1j54BaLjm5TDLaPeYI8rja294NbbZ6TJx0MGV8czzPy8_OnH5dfq6vrL98uP15Vtmn5XCnQteLQboXQbKMlE0oKVE2LCpTTqrW4UQoQkXUAwlngHDadEFI74EqLM3J-0J1S_LVgns3os8VhgIBxyUbqtmmFEg-CNdMb2SpewNf_gTdxSaF8ojB1sZRSFag9QDbFnBN2Zkp-hLQznJm1Q7Pv0KwFrVf7Ds0q_uoovmxHdPevjqUV4M0RgGxh6BKEEvg9p0pCYr_lxYHDEu6tx2Sy9RhKJz6hnY2L_oFV_gKk3bow</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Porsbjerg, Celeste</creator><creator>von Linstow, Marie-Louise</creator><creator>Ulrik, Charlotte Slrik</creator><creator>Nepper-Christensen, Steen Christian</creator><creator>Backer, Vibeke</creator><general>Elsevier Inc</general><general>American College of Allergy, Asthma, & Immunology</general><general>American College of Allergy and Immunology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>7TS</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Outcome in adulthood of asymptomatic airway hyperresponsiveness to histamine and exercise-induced bronchospasm in childhood</title><author>Porsbjerg, Celeste ; von Linstow, Marie-Louise ; Ulrik, Charlotte Slrik ; Nepper-Christensen, Steen Christian ; Backer, Vibeke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-7a8271a5b338098603763e745e7a7d875ce977aeee0faa3dca11a9f3368da1783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Asthma - etiology</topic><topic>Asthma - immunology</topic><topic>Asthma, Exercise-Induced - complications</topic><topic>Asthma, Exercise-Induced - immunology</topic><topic>Biological and medical sciences</topic><topic>Bronchial Hyperreactivity - complications</topic><topic>Bronchial Hyperreactivity - immunology</topic><topic>Child</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Denmark</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Histamine - administration & dosage</topic><topic>Histamine - immunology</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Pneumology</topic><topic>Regression Analysis</topic><topic>Respiratory Function Tests</topic><topic>Risk Factors</topic><topic>Skin Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Porsbjerg, Celeste</creatorcontrib><creatorcontrib>von Linstow, Marie-Louise</creatorcontrib><creatorcontrib>Ulrik, Charlotte Slrik</creatorcontrib><creatorcontrib>Nepper-Christensen, Steen Christian</creatorcontrib><creatorcontrib>Backer, Vibeke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>Physical Education Index</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of Allergy, Asthma & Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Porsbjerg, Celeste</au><au>von Linstow, Marie-Louise</au><au>Ulrik, Charlotte Slrik</au><au>Nepper-Christensen, Steen Christian</au><au>Backer, Vibeke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome in adulthood of asymptomatic airway hyperresponsiveness to histamine and exercise-induced bronchospasm in childhood</atitle><jtitle>Annals of Allergy, Asthma & Immunology</jtitle><addtitle>Ann Allergy Asthma Immunol</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>95</volume><issue>2</issue><spage>137</spage><epage>142</epage><pages>137-142</pages><issn>1081-1206</issn><eissn>1534-4436</eissn><coden>ANAEA3</coden><abstract>Studies of the clinical outcome in adulthood of asymptomatic airway hyperresponsiveness (AHR) to histamine or exercise-induced bronchospasm (EIB) detected in childhood in general population samples are sparse and have produced conflicting results.
To describe the outcome of asymptomatic AHR to histamine and EIB.
Data from a 12-year follow-up study of a random population sample of individuals aged 7 to 17 years at enrollment were analyzed; only individuals without asthma at enrollment were included in the analysis. AHR to inhaled histamine, EIB, lung function, and sensitization to aeroallergens were measured.
Among the 281 nonasthmatic participants studied, 58 (22%) had AHR to histamine, 33 (12%) had EIB, and 82 (29%) had AHR to histamine and/or EIB. At follow-up, 37.9% of individuals with AHR to histamine and 30% of individuals with EIB had developed current asthma, compared with only 5% of individuals in whom these test results were negative. In patients with AHR to histamine, parental asthma (odds ratio [OR], 12.6; 95% confidence interval [CI], 1.5-108.5), furred pets ownership (OR, 6.0; 95% CI, 1.2-19.6), and dermatitis and/or rhinitis in childhood (OR, 2.2; 95% CI, 1.1-5.1) predicted the subsequent development of asthma, whereas no risk factors for the development of asthma could be identified in individuals with EIB
.
Asymptomatic AHR to histamine and EIB in childhood predict the subsequent development of asthma in adulthood. A genetic disposition to asthma, furred pets ownership, and concomitant rhinitis or dermatitis increase the risk of asthma development in individuals with AHR to histamine.</abstract><cop>McLean, VA</cop><pub>Elsevier Inc</pub><pmid>16136762</pmid><doi>10.1016/S1081-1206(10)61202-1</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Asthma - etiology Asthma - immunology Asthma, Exercise-Induced - complications Asthma, Exercise-Induced - immunology Biological and medical sciences Bronchial Hyperreactivity - complications Bronchial Hyperreactivity - immunology Child Chronic obstructive pulmonary disease, asthma Denmark Exercise Test Female Follow-Up Studies Histamine - administration & dosage Histamine - immunology Humans Immunopathology Male Medical sciences Multivariate Analysis Pneumology Regression Analysis Respiratory Function Tests Risk Factors Skin Tests |
| title | Outcome in adulthood of asymptomatic airway hyperresponsiveness to histamine and exercise-induced bronchospasm in childhood |
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