A remarkably effective catalyst for the asymmetric transfer hydrogenation of aromatic ketones in water and air

A remarkably effective catalyst for the asymmetric transfer hydrogenation of aromatic ketones in water and air

A Rh(III) complex generated in situ from [Cp*RhCl2]2 and (1R,2R)-N-(p-toluenesulfonyl)-1,2-cyclohexanediamine (TsCYDN) serves as a remarkably effective, robust catalyst for the asymmetric transfer hydrogenation of aromatic ketones by HCOONa in water in air, affording alcohols in up to 99% ee.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2005-09 (35), p.4447-4449
Hauptverfasser: Wu, Xiaofeng, Vinci, Daniele, Ikariya, Takao, Xiao, Jiangliang
Format: Artikel
Sprache:eng
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Zusammenfassung:A Rh(III) complex generated in situ from [Cp*RhCl2]2 and (1R,2R)-N-(p-toluenesulfonyl)-1,2-cyclohexanediamine (TsCYDN) serves as a remarkably effective, robust catalyst for the asymmetric transfer hydrogenation of aromatic ketones by HCOONa in water in air, affording alcohols in up to 99% ee.
ISSN:1359-7345
1364-548X
DOI:10.1039/b507276j