Analysis of IL10 haplotypic associations with severe malaria

We investigated the association between severe malaria and genetic variation of IL10 in Gambian children, as several lines of evidence indicate that IL10 is protective against severe malaria and that IL10 production is genetically determined. We began by identifying five informative SNPs in the Gamb...

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Veröffentlicht in:	Genes and immunity 2005-09, Vol.6 (6), p.462-466
Hauptverfasser:	Wilson, J N, Rockett, K, Jallow, M, Pinder, M, Sisay-Joof, F, Newport, M, Newton, J, Kwiatkowski, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anemia Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Child Chromosomes full-paper Gambia Gene Expression Genes Genetic aspects Genetic diversity Genetic Predisposition to Disease - genetics Genetic variation Genotype Haplotypes Health aspects Human Genetics Humans Immunology Interleukin 1 Interleukin 10 Interleukin-10 - genetics Investigations Linkage Disequilibrium Malaria Malaria, Falciparum - ethnology Malaria, Falciparum - genetics Malaria, Falciparum - immunology Polymorphism, Single Nucleotide Risk factors Single-nucleotide polymorphism
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