Increased thymic output in HIV-negative patients after antiretroviral therapy
To determine the effects of antiretroviral therapy on thymic output independent of HIV infection. Thymic output was evaluated by quantifying signal joint T-cell receptor (TCR) recombination excision circles in peripheral blood lymphocytes from HIV-negative patients undergoing prophylactic antiretrov...
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| Veröffentlicht in: | AIDS (London) 2005-09, Vol.19 (14), p.1467-1472 |
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| creator | GRAHAM, Daniel B BELL, Michael P HUNTOON, Catherine J WEAVER, Joel G. R HAWLEY, Nanci BADLEY, Andrew D MCKEAN, David J |
| description | To determine the effects of antiretroviral therapy on thymic output independent of HIV infection.
Thymic output was evaluated by quantifying signal joint T-cell receptor (TCR) recombination excision circles in peripheral blood lymphocytes from HIV-negative patients undergoing prophylactic antiretroviral therapy. Additionally, effects of the HIV protease inhibitor nelfinavir were assessed in vivo on TCR-induced death of murine double-positive thymocytes.
Five out of seven HIV-negative patients undergoing prophylactic antiretroviral therapy exhibited a dramatic increase (1-3 log10) in recent thymic emigrants containing signal joint TCR recombination excision circles while their peripheral T cell compartments remained relatively unaffected. None of the patients developed subsequent HIV infections. Interestingly, nelfinavir did not have significant effects on TCR-induced apoptosis of murine thymocytes in vivo.
Antiretroviral therapy augments thymic output independent of HIV. Furthermore, nelfinavir does not dramatically affect TCR-induced thymocyte death in mice, thus central tolerance remains intact. |
| doi_str_mv | 10.1097/01.aids.0000182520.69159.8a |
| format | Article |
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Thymic output was evaluated by quantifying signal joint T-cell receptor (TCR) recombination excision circles in peripheral blood lymphocytes from HIV-negative patients undergoing prophylactic antiretroviral therapy. Additionally, effects of the HIV protease inhibitor nelfinavir were assessed in vivo on TCR-induced death of murine double-positive thymocytes.
Five out of seven HIV-negative patients undergoing prophylactic antiretroviral therapy exhibited a dramatic increase (1-3 log10) in recent thymic emigrants containing signal joint TCR recombination excision circles while their peripheral T cell compartments remained relatively unaffected. None of the patients developed subsequent HIV infections. Interestingly, nelfinavir did not have significant effects on TCR-induced apoptosis of murine thymocytes in vivo.
Antiretroviral therapy augments thymic output independent of HIV. Furthermore, nelfinavir does not dramatically affect TCR-induced thymocyte death in mice, thus central tolerance remains intact.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/01.aids.0000182520.69159.8a</identifier><identifier>PMID: 16135899</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; AIDS/HIV ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretroviral Therapy, Highly Active ; Antiviral agents ; Apoptosis - immunology ; Biological and medical sciences ; Case-Control Studies ; HIV Infections - prevention & control ; HIV Seronegativity - immunology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Immunophenotyping ; Infectious diseases ; Leukocytes, Mononuclear - immunology ; Medical sciences ; Mice ; Middle Aged ; Pharmacology. Drug treatments ; Receptors, Antigen, T-Cell - immunology ; Thymus Gland - immunology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS (London), 2005-09, Vol.19 (14), p.1467-1472</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-cd673a8c52d98804a09d4efdb44b30a47632e9ebf1a60a962c97d19c527b12b13</citedby><cites>FETCH-LOGICAL-c433t-cd673a8c52d98804a09d4efdb44b30a47632e9ebf1a60a962c97d19c527b12b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17139653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16135899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GRAHAM, Daniel B</creatorcontrib><creatorcontrib>BELL, Michael P</creatorcontrib><creatorcontrib>HUNTOON, Catherine J</creatorcontrib><creatorcontrib>WEAVER, Joel G. R</creatorcontrib><creatorcontrib>HAWLEY, Nanci</creatorcontrib><creatorcontrib>BADLEY, Andrew D</creatorcontrib><creatorcontrib>MCKEAN, David J</creatorcontrib><title>Increased thymic output in HIV-negative patients after antiretroviral therapy</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>To determine the effects of antiretroviral therapy on thymic output independent of HIV infection.
Thymic output was evaluated by quantifying signal joint T-cell receptor (TCR) recombination excision circles in peripheral blood lymphocytes from HIV-negative patients undergoing prophylactic antiretroviral therapy. Additionally, effects of the HIV protease inhibitor nelfinavir were assessed in vivo on TCR-induced death of murine double-positive thymocytes.
Five out of seven HIV-negative patients undergoing prophylactic antiretroviral therapy exhibited a dramatic increase (1-3 log10) in recent thymic emigrants containing signal joint TCR recombination excision circles while their peripheral T cell compartments remained relatively unaffected. None of the patients developed subsequent HIV infections. Interestingly, nelfinavir did not have significant effects on TCR-induced apoptosis of murine thymocytes in vivo.
Antiretroviral therapy augments thymic output independent of HIV. Furthermore, nelfinavir does not dramatically affect TCR-induced thymocyte death in mice, thus central tolerance remains intact.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Antiviral agents</subject><subject>Apoptosis - immunology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Seronegativity - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Immunophenotyping</subject><subject>Infectious diseases</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><subject>Thymus Gland - immunology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2L1EAURQtRnJ7RvyAB0V1ivdQ3rmQYnYYRN-q2eKm8aEk6iVWVgf73ZpyGXs7b3M2598Fh7C3wBrgzHzg0GPvc8O3AtqrljXagXGPxGduBNKJWysBztuOtdrUThl-wy5z_bLzi1r5kF6BBKOvcjn3dTyERZuqr8vt4iKGa17KspYpTdbv_WU_0C0u8p2rZgqaSKxwKpQqnEhOVNN_HhOPWpYTL8RV7MeCY6fUpr9iPzzffr2_ru29f9tef7uoghSh16LURaINqe2ctl8hdL2noOyk7wVEaLVpy1A2AmqPTbXCmB7fxpoO2A3HF3j_uLmn-u1Iu_hBzoHHEieY1e22VFJbrJ0EwsgWj5QZ-fARDmnNONPglxQOmowfuH7R7Dv5Buz9r9_-1e4tb-83pzdodqD93T5434N0JwBxwHBJOIeYzZ0A4rYT4B1LpjTI</recordid><startdate>20050923</startdate><enddate>20050923</enddate><creator>GRAHAM, Daniel B</creator><creator>BELL, Michael P</creator><creator>HUNTOON, Catherine J</creator><creator>WEAVER, Joel G. 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R ; HAWLEY, Nanci ; BADLEY, Andrew D ; MCKEAN, David J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-cd673a8c52d98804a09d4efdb44b30a47632e9ebf1a60a962c97d19c527b12b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Antiviral agents</topic><topic>Apoptosis - immunology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>HIV Infections - prevention & control</topic><topic>HIV Seronegativity - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Immunophenotyping</topic><topic>Infectious diseases</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>Thymus Gland - immunology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GRAHAM, Daniel B</creatorcontrib><creatorcontrib>BELL, Michael P</creatorcontrib><creatorcontrib>HUNTOON, Catherine J</creatorcontrib><creatorcontrib>WEAVER, Joel G. 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R</au><au>HAWLEY, Nanci</au><au>BADLEY, Andrew D</au><au>MCKEAN, David J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased thymic output in HIV-negative patients after antiretroviral therapy</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2005-09-23</date><risdate>2005</risdate><volume>19</volume><issue>14</issue><spage>1467</spage><epage>1472</epage><pages>1467-1472</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>To determine the effects of antiretroviral therapy on thymic output independent of HIV infection.
Thymic output was evaluated by quantifying signal joint T-cell receptor (TCR) recombination excision circles in peripheral blood lymphocytes from HIV-negative patients undergoing prophylactic antiretroviral therapy. Additionally, effects of the HIV protease inhibitor nelfinavir were assessed in vivo on TCR-induced death of murine double-positive thymocytes.
Five out of seven HIV-negative patients undergoing prophylactic antiretroviral therapy exhibited a dramatic increase (1-3 log10) in recent thymic emigrants containing signal joint TCR recombination excision circles while their peripheral T cell compartments remained relatively unaffected. None of the patients developed subsequent HIV infections. Interestingly, nelfinavir did not have significant effects on TCR-induced apoptosis of murine thymocytes in vivo.
Antiretroviral therapy augments thymic output independent of HIV. Furthermore, nelfinavir does not dramatically affect TCR-induced thymocyte death in mice, thus central tolerance remains intact.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16135899</pmid><doi>10.1097/01.aids.0000182520.69159.8a</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult AIDS/HIV Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active Antiviral agents Apoptosis - immunology Biological and medical sciences Case-Control Studies HIV Infections - prevention & control HIV Seronegativity - immunology Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Immunophenotyping Infectious diseases Leukocytes, Mononuclear - immunology Medical sciences Mice Middle Aged Pharmacology. Drug treatments Receptors, Antigen, T-Cell - immunology Thymus Gland - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Increased thymic output in HIV-negative patients after antiretroviral therapy |
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