Robustness and state-space structure of Boolean gene regulatory models

Robustness to perturbation is an important characteristic of genetic regulatory systems, but the relationship between robustness and model dynamics has not been clearly quantified. We propose a method for quantifying both robustness and dynamics in terms of state-space structures, for Boolean models...

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Veröffentlicht in:	Journal of theoretical biology 2007-12, Vol.249 (4), p.749-765
Hauptverfasser:	Willadsen, Kai, Wiles, Janet
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Boolean model Cell Cycle - genetics Drosophila melanogaster Drosophila melanogaster - genetics Gene regulatory network Gene Regulatory Networks Genes, Fungal Genes, Insect Models, Genetic Robustness Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics
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