Polygoni cuspidati radix inhibits the activation of Syk kinase in mast cells for antiallergic activity

The antiallergic activity of Polygoni cuspidati radix (PR) and the mechanism of action by which it functions were investigated in this study. The extract of PR exhibited potent inhibitory activity in mast cells; its IC50 values were 62 ± 2.1 μg/ml for RBL-2H3 mast cells and 46 ± 3.2 μg/m for bone ma...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2007-12, Vol.232 (11), p.1425-1431
Hauptverfasser:	Lim, B.O, Lee, J.H, Ko, N.Y, Mun, S.H, Kim, J.W, Kim, D.K, Kim, J.D, Kim, B.K, Kim, H.S, Her, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylaxis - drug therapy Anaphylaxis - enzymology Anaphylaxis - pathology Animals Anti-Allergic Agents - chemistry Anti-Allergic Agents - pharmacology Antigens - pharmacology Bone Marrow Cells - enzymology Bone Marrow Cells - pathology Cell Line cultured cells Disease Models, Animal enzyme activation Enzyme Activation - drug effects Fallopia japonica Fallopia japonica - chemistry gene expression regulation Histamine - metabolism human health hypersensitivity Inflammation - drug therapy Inflammation - enzymology interleukin-4 Interleukin-4 - biosynthesis Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - metabolism Male MAP Kinase Kinase 4 - metabolism mast cells Mast Cells - enzymology Mast Cells - pathology medicinal plants messenger RNA Mice Mice, Inbred ICR Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Oriental traditional medicine Phosphorylation - drug effects Plant Extracts - chemistry Plant Extracts - pharmacology protein-tyrosine kinases Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects spleen tyrosine kinase Syk Kinase tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - biosynthesis
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