Structure−Activity Studies of Novel Cyanoguanidine ATP-Sensitive Potassium Channel Openers for the Treatment of Overactive Bladder

A series of novel cyanoguanidine derivatives was designed and synthesized. Condensation of N-(1-benzotriazol-1-yl-2,2-dichloropropyl)-substituted benzamides with N-(substituted-pyridin-3-yl)-N ‘-cyanoguanidines furnished N-{2,2-dichloro-1-[N ‘-(substituted-pyridin-3-yl)-N ‘ ‘-cyanoguanidino]propyl}-...

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Veröffentlicht in:	Journal of medicinal chemistry 2007-11, Vol.50 (24), p.6265-6273
Hauptverfasser:	Perez-Medrano, Arturo, Brune, Michael E, Buckner, Steven A, Coghlan, Michael J, Fey, Thomas A, Gopalakrishnan, Murali, Gregg, Robert J, Kort, Michael E, Scott, Victoria E, Sullivan, James P, Whiteaker, Kristi L, Carroll, William A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Benzamides - chemical synthesis Benzamides - pharmacokinetics Benzamides - pharmacology Biological and medical sciences Biological Availability Crystallography, X-Ray Dogs Electric Stimulation Female Guanidines - chemical synthesis Guanidines - pharmacokinetics Guanidines - pharmacology Humans In Vitro Techniques Ion Channel Gating KATP Channels - agonists KATP Channels - physiology Medical sciences Muscle Relaxation Muscle, Smooth - drug effects Muscle, Smooth - physiology Pharmacology. Drug treatments Potassium Channels, Inwardly Rectifying - agonists Potassium Channels, Inwardly Rectifying - physiology Structure-Activity Relationship Swine Urinary Bladder - cytology Urinary Bladder - drug effects Urinary Bladder - physiology Urinary Bladder, Overactive - drug therapy Urinary Bladder, Overactive - physiopathology Urinary system Urodynamics
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